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24.04.2014

Herpes vaccine progress, alternative medicines list - Plans Download

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Genital herpes is a very common sexually transmitted infection (STI) that is estimated to infect 776,000 people in the United States each year.
Last week, the pharmaceutical company Agenus reported positive mid-stage findings in the clinical trial of a new vaccine, HerpV, which contains a pharmacological agent called QS-21 Stimulon that is designed to boost the body’s own immune reaction. Researchers measured how much virus each participant was releasing 45 days before the vaccines were given and then again after three doses of HerpV or the placebo were administrated. The trial is continuing, and most participants were given booster shots six months after the initial three doses of the vaccine.
Another company that has been working on a herpes vaccine, SmithKline Beecham, released results of its clinical trial earlier this fall, and the results were somewhat promising, though less so than had been hoped.
Though this was not quite what researchers had hoped for, they noted that such a vaccine could still make a difference if it was given to girls before they become sexually active. Finally, the National Institute of Health announced last week that it was starting enrollment on clinical trials of yet another vaccine to prevent HSV-2, this one developed by David Knipe, a professor of microbiology and immunobiology at Harvard Medical School, and manufactured by Sanofi Pasteur.
Currently, there are vaccines on the market that can prevent infection with two STIs: human papillomavirus (HPV) and hepatitis B. It used to be believed that HSV-1 caused herpes infections of the mouth (often thought of as cold sores) and HSV-2 was responsible for those infections of the genitals, but researchers now understand that either virus can infect the genitals or the mouth.


The results revealed a 15 percent reduction in the release of the virus by participants who received the vaccine.
The company says that it will have more data next year on the efficacy of this approach to preventing herpes.
Fewer participants who received the vaccine contracted genital herpes during follow-up than those who got the placebo (3 percent versus 11 percent). This one is referred to as a replication-defective vaccine, which means it uses the virus itself, but scientists have removed two key proteins from it so that it cannot multiply to cause genital herpes.
Another vaccine would be great news, especially given how widespread herpes is in the United States.
The vaccine was partially effective at preventing herpes simplex virus type 1 (HSV-1), but did not protect women from herpes simplex virus type 2 (HSV-2). Still, the vaccines in development are focused on HSV-2, as it remains the cause of most genital infections.
Researchers have been working for decades on a vaccine to prevent infection, and recently there has been some progress made on this front, with three vaccines in some stage of testing. The uninfected partner was given either the vaccine or a placebo and was followed for 19 months.


In fact, the vaccine was about 75 percent effective in preventing sores in women who had never been infected with either HSV-1 or HSV-2. We were partially successful against half of the equation – protecting women from genital disease caused by HSV-1,” said Robert Belshe, MD, director of the Saint Louis University Center for Vaccine Development and lead author of the study.
Secondary and exploratory objectives are to confirm the immunogenicity seen in the first study.After the initial screening, study participants have a 45 day baseline observation period on trial entry before receiving the first of their three therapeutic vaccine injections.
Researchers found that two or three doses of the investigational vaccine offered significant protection against genital herpes disease caused by HSV-1.
Researchers are conducting laboratory tests on serum obtained from study participants as they continue to study why the vaccine protected women from genital disease caused by HSV-1 and not HSV-2.




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Comments to “Herpes vaccine progress”

  1. centlmen:
    With herpes generally don’t we update.
  2. POLICE:
    Reports have documented acyclovir-resistant HSV trials that are aimed directly at preventing.