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12.12.2014

Herpes treatment for melanoma, the latest health news - How to DIY

Author: admin
A new treatment may be in the cards for patients with skin cancer - in the form of a genetically engineered herpes virus.
In a phase 3 trial, researchers found the treatment, called Talimogene Laherparepvec (T-VEC), slowed disease progression in patients with melanoma - the deadliest form of skin cancer. According to the research team - led by Kevin Harrington, professor of biological cancer therapies at ICR and honorary consultant at the Royal Marsden - their study represents the first phase 3 trial to demonstrate the benefits of viral immunotherapy for cancer patients.
Developed by biopharmaceutical company Amgen - who funded the study - T-VEC is a genetically modified form of the herpes simplex virus type 1 (HSV-1), which can multiply inside cancer cells and kill them. Compared with patients who received the control immunotherapy, those who received T-VEC showed a much better treatment response. The treatment response of some patients given T-VEC even lasted longer than 3 years - a time period oncologists frequently use as a benchmark for a cure when it comes to cancer immunotherapy, according to the team.
Patients with stage III and early stage IV melanoma who were given the control immunotherapy survived for an average of 21.5 months, the results show, while those who received T-VEC lived for an average of 41 months. The researchers found patients with stage IIIB, IIIC and IVM1a melanoma - less advanced forms of the cancer - showed the strongest responses to T-VEC, as did those who had not undergone any other treatment for the disease.
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The results show that 163 patients with stage-three and early stage-four melanoma who were treated with T-VEC lived for an average of 41 months. That was compared with an average survival of 21.5 months for the patients who were given the current best immunotherapy drugs.


The response was most pronounced in patients with less advanced cancers, underlining the potential benefit as a first-line treatment for metastatic cancers, which have spread to other parts of the body and cannot be surgically removed. T-VEC is a modified form of herpes virus which multiplies inside cancer cells and bursts them from within. The results showed that 16.3% of the group given T-VEC responded to treatment and were still in remission after six months.
In a groundbreaking Phase III trial, researchers demonstrated the first-ever viral treatment for cancer. A genetically engineered herpes virus proved to halt the progression of skin cancer in its tracks, the Institute of Cancer Research reported.
Researchers gave 436 patients with aggressive, inoperable malignant melanoma either an injection of the viral therapy, dubbed Talimogene Laherparepvec (T-VEC), or a control immunotherapy.
The researchers noted responses were most dramatic in patients in patients with less advanced cancer and who had not yet received treatment, suggesting T-VEC is a good candidate for a first-line melanoma treatment.
T-VEC is a modified form of herpes simplex virus type-1, it multiplies inside cancer cells and causes them to explode. This year, around 73,870 new cases of melanoma will be diagnosed, and almost 10,000 people will die from the disease.
Harrington and colleagues randomized 436 patients with advanced, inoperable malignant melanoma to receive either an injection with T-VEC or a control immunotherapy. This indicates that T-VEC could be used as a primary treatment for inoperable metastatic melanoma, notes the team.
Louis, MO, which revealed how personalized vaccines can trigger a strong immune response against tumor mutations in patients with melanoma.


It’s exciting to see the potential of viral treatment realized in a Phase III trial, and there is hope that therapies like this could be even more effective when combined with targeted cancer drugs to achieve long term control and cure,” he added. And because viral treatment can target cancer cells specifically, it tends to have fewer side-effects than traditional chemotherapy or some of the other new immunotherapies,” said U.K. The new treatment method works by attacking and killing cancer cells and prompting the immune system to destroy tumors.
And because viral treatment can target cancer cells specifically, it tends to have fewer side-effects than traditional chemotherapy or some of the other new immunotherapies," said trial leader Professor Kevin Harrington, Professor of Biological Cancer Therapies at the ICR and Honorary Consultant at The Royal Marsden.
About 16 percent of the group treated with T-VEC exhibited a treatment response of more than six months, compared with only 2.1 percent of the control group.
Patients with stage III and early stage IV melanoma who received the new viral treatment lived an average of 41 months, compared with an average survival rate of 21.5 months in patients who received immunotherapy.
The version used in the treatment was genetically engineered to produce the molecule GM-CSF, which drives the immune system to destroy tumors. Some of the patients in the T-VEC group had responses that lasted for as long as three years, which is a milestone that is often considered "cured" by immunotherapy standards.



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