Herpes simplex 1 treatment famciclovir dosage, treat cold sores - PDF Review

Genital herpes is a chronic viral infection caused by two types of herpes simplex virus: HSV 1 and HSV 2. The mainstay of managing genital herpes is to treat all symptomatic patients with oral antiviral therapy. Jessica has been prescribed Valacyclovir 1000mg bid for 10 days which is an ideal treatment strategy for a primary infection.
Since recurrence of genital herpes is common, an ideal approach is to recommend to the physician to prescribe an additional course of valacyclovir 1000mg PO for 3 days for recurrent episodes.
Following treatment with the antimicrobials, a follow-up culture for test of cure should be done within 3-7 days to ensure that Jessica has responded to the antimicrobials effectively.


Returning to our case, Jessica has multiple risk factors such as her age, probable genital herpes, and sex with multiple partners. Although genital herpes is primarily due to genital intercourse, there is an increasing likelihood of it being contracted from oral sex.
Condom use should be encouraged to reduce transmission of herpes simplex virus to other sex partners. Jessica should be informed that there is no cure for genital herpes and that the antiviral therapy only helps to control the symptoms of the episodes. Moreover, females are at higher risk of acquiring genital herpes from male partners than vice versa.


The three commonly used oral antivirals are valacyclovir, famciclovir, and acyclovir (Table 1). Although it is not mandatory to report genital herpes, physicians and laboratories are strongly encouraged to report this infection to the public health authorities.
Canadian Guidelines on Sexually Transmitted infections- Genital Herpes Simplex Virus (HSV) Infections, January 2008.

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