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27.08.2014

Herpes 2 vaccine 2015, how do you test for herpes type 2 - For Begninners

Author: admin
Genital herpes currently affects up to one in six Americans between the ages of 14 and 49, yet no vaccine or cure for this, common sexually transmitted infection (STI) exists.
The herpes virus first infects epithelial cells before invading the neurons, where it remains latent until later reactivated by hormones or stress. The first step of this process, or the “prime,” involves a conventional vaccination with weakened HSV-2, which activates HSV-2-specific T cells throughout the body. In addition to effective protection, the prime and pull immunization also causes little to no inflammation in the genital tract, a problem which had plagued previous vaccine models that fought herpes.
In addition to a vaccine against genital herpes, the prime and pull method has many other promising applications.


The researchers’ “prime and pull” immunization brings T cells, pictured here in a scanning electron micrograph, to the site of infection, allowing for effective vaccination.
However, a recent paper by Yale professor Akiko Iwasaki and postdoctoral fellow Haina Shin published in Nature reports a promising new vaccine strategy termed “prime and pull” that could easily and effectively protect against the main cause of genital herpes, herpes simplex virus 2 (HSV-2). Mice treated with the method had increased survival rates, as compared to mice given the immunization (prime) without the chemokine pull, and did not develop clinical herpes when infected with the virus.
If T cells can indeed prevent the virus from getting into the nervous system, Iwasaki adds, the vaccination “can hopefully provide protection for life.”. In the future, Iwasaki would like to see other researchers use the method both for their own applications and for making the new herpes vaccine clinically available.


But under a grant from the National Institute of Allergy and Infectious Diseases Division of the National Institutes of Health (NIH), the effort mounted by Vical is directed at developing a plasmid DNA-based vaccine to inhibit recurring lesions in patients latently infected with HSV-2. The vaccine also is intended to reduce viral shedding to help prevent transmission to others. And while still in the preclinical stage, results have shown a reproducible statistically significant reduction in viral lesion occurrence in guinea pigs latently infected with HSV-2.Vical's HSV-2 DNA vaccine program, as seen below, involves collaboration with Lawrence Corey's group at the Fred Hutchinson Research Center.




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Comments to “Herpes 2 vaccine 2015”

  1. RAZiNLi_QIZ:
    Moistening a cotton swab and held several times a day, 3-4 days with the herpes.
  2. GULESCI_QAQA_KAYIFDA:
    System at its full capacity contact, that is.