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After being told she had bone cancer, Florencia Pistritto’s mind was focused on one thing: survival. So when it was explained that the chemotherapy she needed might leave her with long term side-effects, this barely registered. Over the next ten months Florencia was given 17 cycles of cisplatin, a widely used form of chemotherapy.
However, after her first session, in July 2014, she noticed what she calls a ringing noise in her ears. Each new session of chemotherapy marked a further deterioration in her hearing, and after five cycles she needed hearing aids in both ears. For Florencia, who speaks fluent Italian and who hoped to start a new career as a translator once her treatment was completed, it was a worrying development. Cisplatin is given to 25 per cent of cancer patients, and while it is effective at destroying cancer cells, it may also damage the tiny hairs inside the ear that are crucial for hearing. Striking a balance between the need to eradicate cancer cells with the need to maintain quality of life after the treatment is difficult.
A study just published in the journal Cancer found that one in five women over 65 with newly diagnosed breast cancer had lost the ability to complete some of the basic tasks necessary for independent living within one year of starting treatment as a result of the treatment itself.
For example, a study published in JAMA Internal Medicine showed that women who’ve had radiotherapy for breast cancer had up to a 4 per cent greater risk of heart attack — radiation is linked to coronary artery disease, cardiomyopathy (disease of the heart muscle) and heart valve disease. At least 500,000 people in the UK are now living with ill health or disability due to their cancer treatment according to Macmillan Cancer Support. Problems include chronic fatigue, sexual difficulties, mental health problems, urinary problems such as incontinence and gastrointestinal problems.
Professor Jane Maher, a consultant oncologist at Mount Vernon Cancer Centre, Hillingdon, West London, explains that some problems may only emerge months after treatment, and can persist for ten years or more. However, as more people now live many years after undergoing cancer treatment, attention is turning to try to ensure that those years are not mired by the effects of that treatment. The charity Action On Hearing Loss has just announced a research grant to investigate exactly how chemotherapy drugs enter the hair cells in the ear and cause the irreparable damage.
Switching treatments may help prevent some long-term effects, suggests Dr Timothy Yap, a clinician scientist at The Institute Of Cancer Research, London, and consultant medical oncologist at The Royal Marsden Hospital, London. Another option is trying to personalise the treatment using drugs targeted at the patient’s specific cancer. Dr Yap says that in certain groups of patients these targeted treatments not only have fewer toxic side-effects than chemotherapy, they can in some cases be more effective. Also being introduced are genetic tests that can identify patients who won’t respond to breast cancer chemotherapy, for example, so they can avoid side-effects from treatments that would never have helped them. The National Institute of Healthcare and Excellence (NICE) updated guidance this month to recommend patients are given a new genetic test called Oncotype DX which can predict which women with certain types of early stage breast cancer will respond to chemotherapy. This test helps clinicians ‘make more informed decisions about who will benefit most from treatment with chemotherapy’, explains Dr Jeremy Braybrooke, a consultant medical oncologist at University Hospitals Bristol NHS Foundation Trust.


If chemotherapy is unsuitable after surgery, radiotherapy or hormone treatments may be used instead. Strategies are now being introduced to minimise some of the debilitating side-effects of radiotherapy, too. She knows she’s incredibly lucky to be still here — but her hearing is now so limited even with hearing aids that she has to wear constantly, that she will not be able to work as a translator.
At the age of 31 and two weeks after she got married, Kelly Larkin-Holmes felt a lump in her breast.
After having two breast biopsies and then receiving a call from her doctor the very next afternoon, Camille Mills says that she instinctively knew she had cancer. Breast cancer survivor Debra Jarvis was diagnosed just five days after her mother was also diagnosed with breast cancer. Watch as Diane Larkin, breast cancer survivor, talks about being diagnosed while coping with her daughter going through cancer treatment. A nine-valent vaccine, being developed by Merck and currently under investigation, covers HPV subtypes 31, 33, 45, 52, and 58, besides 6, 11, 16 and 18. In 2011, the International Agency for Cancer Research (IARC) expanded its list of carcinogenic HPV subtypes beyond HPV 16 and 18 to include HPV 31, 33, 35, 39, 45, 51, 52, 56, 58, and 59. A study published last week in Cancer Epidemiology, Biomarkers & Prevention looked at the types of HPV infections in 12,514 women, ages 15 to 45, enrolled in the placebo arms of three clinical trials testing the quadrivalent HPV vaccine. While more potent and effective vaccines promise near elimination of cervical cancer, a lack of public awareness and adherence to vaccination programs is hindering progress in the prevention of HPV-related cancers. It appears that cervical cancer is not the only cancer that could be prevented by these vaccines. Bob Margolis, a three-time survivor of cancer, vouches for the importance of HPV vaccination in the AACR Cancer Progress Report 2014. The veteran television journalist, who was diagnosed with stage 2 triple negative breast cancer last year, has been in remission for more than five months now. Florencia, like many who have cisplastin and other forms of chemotherapy, suffers from so-called ‘chemo brain’, characterised by problems concentrating and fatigue. Dr Yap treats selected lung cancer patients with targeted drugs called epidermal growth factor receptor (EGFR) inhibitors, such as Tarceva, Iressa and Afatinib. A study at Harvard University found for women having radiotherapy for breast cancer it cut exposure to the heart by up to 96 per cent. Watch as Kelly discusses her diagnosis with stage I-B breast cancer, her concerns about experiencing early menopause as a result of treatment, and the possibility of not being able to have children. She discusses her unique perspective as a patient and a chaplain who worked at Seattle Cancer Care Alliance at the time. She discusses how her daughter provided her with tips for getting through treatment, like sucking on ice chips during chemotherapy. After a darkened spot was found during a routine mammogram, a biopsy confirmed that she had cancer.


Information on this site may or may not be true and BabyRazzi LLC makes no warranty as to the validity of any claims. Gardasil and Cervarix, two Food and Drug Administration-approved human papillomavirus (HPV) vaccines, are proving to be very effective in preventing infections with HPV subtypes 16 and 18, which cause the majority of cervical cancers. While HPV subtypes 16 and 18 are well-established as causative agents of cervical intraepithelial neoplasia (CIN), the precursors for invasive cervical cancers, HPV subtypes 31, 33, 35, 45, 52, and 58 are the next most frequent types detected in this disease, according to a 2012 publication by IARC. The study found that about 55 percent of CIN 1, about 78 percent of CIN 2, about 91 percent of CIN 3, and nearly 100 percent of adenocarcinoma in-situ lesions were attributed to seven of the nine HPV subtypes covered by the new investigational nine-valent HPV vaccine.
According to a Centers for Disease Control and Prevention (CDC) report, vaccination coverage in the United States is increasing rather slowly among girls ages 13 to 17, a key group for whom vaccination is recommended. A significant proportion of vulvar, vaginal, penile, anal, oral, and other head and neck cancers are related to HPV infections. Margolis, a sports writer and a father of three, shares his experience with a diagnosis of HPV-related stage IV head and neck cancer, and his commitment to encouraging people to talk about it and get help. This is certainly a step in the right direction, but clearly, a lot more needs to be done if we are to exploit the true potential of vaccination and reap the benefits of one of the best tools we have so far in our efforts to prevent cancer.
She also shares her experience with her mother's diagnosis, which came the day before Kelly started chemotherapy. Watch as she talks about the importance of mammography, shares about her struggles with treatment, and acknowledges the many ""teachers"" she felt she had along the way who helped her through it all. Diane was inspired to share her story after experiencing the support she and her daughter found in this shared journey.
Her daughter asked a colleague at Columbia Medical School for the best surgeon in the Seattle area, and Dr.
But how effective is the nine-valent vaccine, and how is it better than Gardasil and Cervarix, which can prevent infection with the HPV subtypes that cause 70 percent of all cervical cancers? While wo do not yet have definitive evidence of protection against these cancers with HPV vaccines, it does seem like a possibility.
Camille also talks about her treatment, which included a lumpectomy as well as interstitial breast brachytherapy, a type of radiation. Keum Ja Bae was impressed by every staff member at SCCA, who helped her feel very comfortable and at ease. They were kind, efficient, intelligent, listened to and answered all of her questions, and truly cared about her. She is now on a mission to raise awareness about SCCA and hopes write a book or memoir about her experience.



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