Earlier this year, a team from UC San Francisco reported on the discovery that a class of commonly prescribed type-2 diabetes drugs, called TZDs (thiazolidinediones, such as Actos and Avandia), promoted the conversion of energy-storing white fat cells into energy-burning brown fat cells. While it was known that TZDs have the ability to change white fat cells to brown fat cells by activating a cell receptor called peroxisome proliferator-activated receptor–gamma (ppar-gamma), the exact mechanism behind this transformation was unclear.
Having previously shown that increasing the activity of a group of enzymes called sirtuins (or Sir2) in mice resulted in increased metabolic activity, the CUMC team has now shown that this boost in metabolism is a result of promoting the browning of white fat. Knowing that sirtuins work by severing the chemical bonds between acetyl groups and proteins in a process known as deacetylation, the researchers wanted to uncover whether sirtuins remove acetyl groups from ppar-gamma and if this deacetylation of ppar-gamma is crucial to the browning of white fat.


A pill may be fine to reduce fat, but peoples eating and life style choices won't change if there is a quick fix. Because TZDs have numerous adverse side effects, including liver toxicity, bone loss and, surprisingly enough, weight gain, the CUMC researchers, led by Domenico Accili, MD, professor of Medicine and the Russell Berrie Foundation Professor at CUMC, were attempting to find a safer way to change white fat to brown fat. They confirmed this is the case by creating a mutant gene of ppar-gamma that, in effect, mimicked the actions of sirtuins and promoted the development of brown fat-like qualities in white fat cells in both mice and human fat tissue.
We are the only animal on earth that is so complacent, we become obese, secondary diseases then illness then death all because we eat, way too much.


A calorie is not a calorie and The first law of thermodynamics is totally misinterpreted by most nutritionists. People need to get familiar with basic biology and understand the consequences of the Hayflick limit and try to slow metabolism (including basal) and not be tricked into doing the the opposite by various billion-dollar industries.



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