Salk researchers have developed a more effective pill that makes the body feel like it has consumed calories, causing it to burn fat. Unlike most diet pills on the market, this new pill, called fexaramine, doesn't dissolve into the blood like appetite suppressants or caffeine-based diet drugs, but remains in the intestines, causing fewer side effects. Ronald Evans, senior author of the new paper said that the pill is like an imaginary meal, and sends out the same signals that normally happen when a person eats a lot of food, so the body starts clearing out space to store it.

When the group gave obese mice a daily pill of fexaramine for five weeks, the mice stopped gaining weight, lost fat and had lower blood sugar and cholesterol levels than untreated mice. Since the pill doesn't reach the bloodstream, it is also likely safer in humans than other FXR-targeting drugs, the researchers hypothesize.
The compound effectively stopped weight gain, lowered cholesterol, controlled blood sugar and minimized inflammation in mice, making it an excellent candidate for a rapid transition into human clinical trials.

Giving one such drug in a daily pill form that only reaches the intestines-without transporting into the bloodstream that would carry the drug throughout the body-not only curtails side effects but also made the compound better at stopping weight gain.

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