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This paper reflects the research and thoughts of a student at the time the paper was written for a course at Bryn Mawr College. The findings in the brain usually take the form of cortical tubers, subepedymal nodules and subependymal giant cell astrocytomas (SEGA).The name Tuberous Sclerosis comes from cortical tubers, which were first named in 1880 by Bourneville.
Tubers are made up of a collection of abnormally sized neurons and their supporting cells (glia). They are most commonly found in the cerebral cortex.The number, size and location of the tubers vary tremendously among patients with TSC.


In the past, they were referred to as "candle guttering" to convey the appearance similar to drippings of wax from a candle.
However, in 5-10% of the cases, these benign lesions can degenerate into subependymal giant cell astrocytomas (SEGA). SEGAs can grow and block the circulation of CSF (cerebrospinal fluid) around the brain and cause hydrocephalus. Hydrocephalus leads to a swelling of the brain and requires immediate neurosurgical intervention.





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