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It’s pretty clear that if we follow the example of our hunter gatherer ancestors, artificial sweeteners should not be part of contemporary Stone Age diets.
In addition to these artificial sweeteners, the FDA has sanctioned a sugar substitute, stevia, as a dietary supplement since 1995. If you were to ask most people why they drink artificially sweetened beverages, the resounding answer would be to enjoy a sweet drink without all the drawbacks of sugar laden sodas. A 2010 prospective study25 of 59,334 pregnant women from Denmark showed for the first time that consumption of artificially sweetened soft drinks significantly increased the risk for pre-term delivery (less than 37 weeks).
Consumption of artificially and sugar-sweetened beverages and incident type 2 diabetes in the Etude Epidemiologique aupres des femmes de la Mutuelle Generale de l’Education Nationale-European Prospective Investigation into Cancer and Nutrition cohort. Put Paleo into action with The Paleo Diet Cookbook and eat your way to weight loss, increased energy, and lifelong health-while enjoying delicious meals.
Artificial sweeteners are completely man-made, processed foods, created in complex laboratory settings.
In addition to artificial sweeteners, “sugar alcohols” also exist, which are not technically the same as artificial sweeteners because they do contain trace amounts of calories and sugar. Studies have found that artificial sweeteners disrupt the body’s natural ability to regulate calorie intake, interpret hunger signals, and deal with food cravings.
Because artificial sweeteners are much sweeter than regular sugar, they activate our taste buds to prefer foods with very strong sweet tastes.
After reviewing over a dozen artificial sweetener studies, researchers deemed artificial sweeteners вЂњcounterintuitive” in terms of helping people to lose weight and become healthier. In animal studies, rats that consumed artificial sweeteners ate more, their metabolism slowed down, and they gained an average of 14% of their body fat, all within about two weeks. The verdict is still out on whether or not artificial sweeteners can lead to serious conditions like cancer. It is actually a natural sweetener, derived from the leaves of the stevia rebaudiana plant. I started Ultimate Paleo Guide to help people get healthy and eat better by making paleo simple by learning the basics of the paleo diet. It should be noted that research regarding artificial sweeteners is still in its infancy, so much of the data is not extremely strong.
For most of the population it seems that the main reason for consuming artificial sweeteners is to reduce calories and lose weight.
Artifical sweeteners may stimulate overeating due to “sweetness satisfaction.” Your brain has the ability to distinguish between real sugar and the artificial stuff. One major problem with artificial sweeteners is their relationship with the cephalic phase in our eating patterns. Essentially, they’re saying that your brain can tell the difference between artificial sweeteners and the real stuff. Dietary displacement is when you consume a diet beverage, a zero-calorie product, or a sugar-free item, and think you can eat more because of this.
We’ve touched a bit on artificial sweeteners and the health risks, benefits, and other effects associated with them in some other articles.
In my book, The Paleo Diet Revised (2010)1 I warned against drinking artificially sweetened soft drinks and further strengthened my opposition to all artificial sweeteners in 2012 with The Paleo Answer.2 Over the past few years numerous epidemiological (population), animal, tissue and human studies have demonstrated the adverse health effects of these synthetic chemicals. Rats allowed to eat their normal chow consumed more food and gained more weight when artificial sweeteners were added to their diet.34-43 The best available evidence indicates that artificial sweeteners when consumed by either laboratory animals or humans promote weight gain by altering the normal gut bacterial biome3, 45 which in turn adversely affects glucose and insulin metabolism and consequently appetite.
Exposure to non-nutritive sweeteners during pregnancy and lactation: Impact in programming of metabolic diseases in the progeny later in life.

Loren Cordain’s The Real Paleo Diet Cookbook with 250 Paleo recipes prove following The Paleo Diet is as delicious and inspiring as it is healthy. The artificial chemicals that make up popular artificial sweeteners like Splenda, Equal, and Sweet N’ Low have been linked with numerous health problems as well as noticeable and immediate changes in food cravings and digestion. Sugar alcohols are associated with many digestive problems and are often combined with artificial sweeteners to enhance sweetness. Consuming them leads people to crave even more sweet foods and drinks because their bodies are confused by the artificial, chemical properties.
However, when we consume artificial sweeteners, no calories or sugar follow the sweet taste. This means people tend to consume even more of these artificially sweetened foods than they would of regular, sugar-sweetened versions.
Artificial sweeteners have been shown to slow down your metabolism and even release insulin into the blood stream, even though they contain no real sugar. This happened even though the rats were not consuming many more calories at all, showing how the artificial sweeteners had negative effects on brain chemistry, insulin levels, fat storing abilities, and metabolism. Studies have also revealed a link between the sweetener and the development of multiple cancers in laboratory animals. Stevia is not an artificial sweetener, although it can be found in packets in powder form, which can make it seem like one.
High-quality stevia is thought to have some trace nutritional benefits (or at least to be far less harmful than other processed sweeteners). When he's not eating 80% paleo, he's challenging himself to do the impossible and build other Impossible Ventures.
One reason artificial sweeteners were originally created was that it was thought they would be a healthy alternative for those battling blood sugar issues. Artificial sweeteners are typically 100-400 times sweeter than regular sugar, so the message they send to the brain is that a lot of sweetness is coming in.
Thus, brain response distinguishes the caloric from the non-caloric sweetener, although the conscious mind could not.
I’m not going to argue against that, as it is a very valid claim, but, in my opinion, overeating due to artificial sweetener consumption is more often than not due to dietary displacement. If you need something sweet and are looking for a sweetener, stevia may be your best bet. A particularly powerful study just published in the October 2014 issue of Nature3 provides a convincing argument against the use of artificial sweeteners in our food supply.
This study is important, because many people may consume much higher concentrations of this chemical by drinking artificially sweetened beverages on a daily basis for years and years.
An interesting outcome of this study was that only artificially sweetened beverages increased the risk for pre-term delivery – and not sugar sweetened soft drinks. Diet soda intake and risk of incident metabolic syndrome and type 2 diabetes in the Multi-Ethnic Study of Atherosclerosis (MESA).
Diet soft drink consumption is associated with an increased risk of vascular events in the Northern Manhattan Study.
Dietary intake and the development of the metabolic syndrome: the Atherosclerosis Risk in Communities study. Association between sugar-sweetened and artificially sweetened soft drinks and type 2 diabetes: systematic review and dose-response meta-analysis of prospective studies. Consumption of artificially-sweetened soft drinks in pregnancy and risk of child asthma and allergic rhinitis.PLoS One.

Intake of artificially sweetened soft drinks and risk of preterm delivery: a prospective cohort study in 59,334 Danish pregnant women. Association between intake of artificially sweetened and sugar-sweetened beverages and preterm delivery: a large prospective cohort study. Artificial sweeteners produce the counterintuitive effect of inducing metabolic derangements.
General and persistent effects of high-intensity sweeteners on body weight gain and caloric compensation in rats. Adverse effects of high-intensity sweeteners on energy intake and weight control in male and obesity-prone female rats. Effects of artificial sweeteners on insulin release and cationic fluxes in rat pancreatic islets.
Experience with the high-intensity sweetener saccharin impairs glucose homeostasis and GLP-1 release in rats. His research emphasis over the past 20 years has focused upon the evolutionary and anthropological basis for diet, health and well being in modern humans. It’s very common to find at least one type of artificial sweetener, if not more, in foods like yogurt, cereal, frozen meals, diet sodas and other diet drinks, gum, breads, condiments, and more.
However, we do know that most artificial sweeteners are not recommended for pregnant women and children (3).
This could have important implications on how effective artificial sweeteners are in their ability to substitute sugar intake. If you consume artificial sweeteners in the form of sodas or foods once in a blue moon, they will have little or no adverse effects upon your long term health. Aspartame was sanctioned for use as a sweetener by the FDA in 1996, followed by sucralose (1999), neotame (2002), and acesulfame (2003). Frequently, it is difficult to translate results from animal experiments into, meaningful recommendations for humans, because large epidemiological studies generally don’t show artificial sweeteners to be risk factors for cancer. You can view a complete list of chemical and non-chemical sweeteners in The Ultimate Paleo Guide To Sugar. Some research even suggests that artificial sweeteners may disrupt how the body counts calories (8). You may think that anytime chemical additives such as artificial sweeteners were permitted into our food supply, they would have been thoroughly tested and conclusively shown to be safe. Cordain’s scientific publications have examined the nutritional characteristics of worldwide hunter-gatherer diets as well as the nutrient composition of wild plant and animal foods consumed by foraging humans. But these studies indicate that sugar sweetened drinks may be less harmful to your developing fetus than are artificially sweetened soft drinks. He is the world’s leading expert on Paleolithic diets and has lectured extensively on the Paleolithic nutrition worldwide. It has been shown that diets with more than 50 grams per day of fructose are associated with insulin resistance, type 2 diabetes, cardio vascular disease, and elevated blood triglycerides. Cordain is the author of six popular bestselling books including The Real Paleo Diet Cookbook, The Paleo Diet, The Paleo Answer, and The Paleo Diet Cookbook, summarizing his research findings.

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