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The women who took folic acid supplements in early pregnancy had a substantial reduction in risk of having a child with autism. Babies born to women who take supplements of the B vitamin folic acid in early pregnancy are significantly less likely to develop autism, a developmental delay characterized by problems with communication and social interaction. Surén says four weeks before and eight weeks after conception appeared to be the critical time for folic acid supplementation to reduce the risk of autism.
Folic acid has positively been linked to development of a protective covering called the neural tube in a fetus. Ezra Susser, a co-author of the folic acid study, is with the Mailman School of Public Health at Columbia University in New York.

The study linking folic acid supplements with a reduced risk of autism is published in The Journal of the American Medical Association.
The findings of a large Norwegian study reinforce those of other researchers that folic acid supplements are important to a healthy pregnancy. The study asked the mothers to describe their food intake and all dietary supplements they took before and during their pregnancies. Mothers deficient in folic acid are at risk of giving birth to infants with physical defects in which a portion of their spinal cords or brains are exposed because the neural tube does not fuse completely.
After the babies were born, investigators followed up with the children through the end of March 2012, looking to see how many developed a form of autism.

They also found no connection between childhood autism and the use of other supplements during pregnancy, and no correlation with maternal intake of folate, the naturally-occuring form of folic acid, through foods.

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