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As director of the Nutrition and Weight Management Center at Boston Medical Center, Caroline Apovian is immersed in the science of dieting. According to the School of Medicine professor of medicine and pediatrics, the high-protein, vegetable-rich, “fat-burning” diet can help people lose as many as nine pounds in the first week, while offering an abundance of food options, including chocolate. BU Today asked Apovian about what makes this diet unlike the myriad plans preceding it, why protein is so important, and whether it’s really possible to lose weight while sleeping.
Apovian: This diet combines two approaches for weight loss and does not eliminate any foods. The initial weight loss is mainly water and salt, so this is very healthy as long as you keep hydrated for the six-day fuel-up. Keep on the same plan of one-day power-up and six-day fuel-up and you will keep the weight off. Technically, if you eat well, and exercise, and get enough sleep, it is a “permanent” solution, in the sense that as long as you maintain healthy routines, you will attain certain consistency in your weight and health.
So you would need to lose 24,500 calories (7 pounds x 3,500 calories) in the next six days–or 4,083 calories per day.
Mark asked a very good question about the calculation for weight loss versus intake and calorie burn via exercise that appears to be in conflict with expectations. I agree weight is not a factor of health exceptions being athletes who are heavy in weight but very fit.
In conclusion though, weight loss is a very complex entity with numerous implications on the human body.


We have realized that as you get older, you need more protein, not less—the body loses one percent muscle mass per year after the age of 30. The power-up first day can help you lose two pounds overnight, then the rest of the week you are on the six-day fuel-up with protein, fruits, veggies, and lean carbs. Fruits, vegetables, and protein in almost limitless quantities can help anyone to lose weight. The problem is that most people want to achieve their weight loss in the most efficient way possible. As you lose muscle your metabolic rate decreases and you cannot eat as much as you used to—therefore you gain weight, like most older people do—older than 30 that is.
The Overnight Diet causes weight loss, keeps muscle mass healthy, and prevents muscle loss. So this is a great diet for older people, because you calculate your DPR, or daily protein requirement, based on 1.5 grams of protein per kilogram of ideal body weight.
Not all bodies work the same way and trying to make all of us conform to a narrow range of so-called acceptable weights does a whole lot to damage the health (both mental and physical) of perfectly normal people.
Thermodynamically it makes a lot of sense, especially with the salt and water– effectively using osmosis to lose water weight, then using low to no-fat foods to cleanse the body even further.
Exploitation would be like “Follow my 5 step guide to losing weight fast by buying all this special food from my company that I’ve crafted specifically for you!” instead she’s like “Hi.
My grandmother put a lot of weight on this way using fresh fruit and was confused until she saw a nutritionist.


Actually, weight has very little to do with actual health; a person can be fat and very healthy or thin and very unhealthy. Apovian is promoting a particular way she has compiled from medical literature that she believes will deliver weight loss in the most reasonable way.
Apovian is trying to do is provide a defintion for eating and maintaining overall health in a way that promotes weight loss. Also, the insane weight loss lasted for about a week and then my body adapted to the diet changes and eventually I was loosing no weight at all. However, to change your set point and actually start losing serious weight, traditional methods of proper exercise and dieting is probably still the most robust strategy. Sporadic fasting (like the one day feul up) has been proven to kick start weight loss, not getting enough sleep causes metabolic distress and can cause unhealthy over eating; apart from these to factors, this diet only modifies Atkins, which all the popular diets out there seem to be doing. Put simply, in order to burn fact you must first lose the unnecessary retained salt and water.



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