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Multiple molecular mechanisms such as insulin resistance, leptin resistance, cell membrane fluidity, abnormal adipocyte command signals and numerous others. Insulin resistance causes not only fat storage and weight gain especially around the central abdominal area but will also increase the risk of inflammation in the body and of many cancers now known to be associated with high insulin levels. We know that high glycemic index [high-GI] and high glycemic load [high-GL] carbohydrate diets can cause short-term or long-term elevations in insulin which can result in insulin resistance through the GLUT4 downregulation mechanism or through other molecular mechanisms. The 'info' button of the purchased diet will discuss numerous nutritional approaches to significantly improve insulin resistance. Fat accumulation in the midsection is a major risk factor for not only insulin resistance and diabetes but for chronic inflammation in the body and many cancers. Leptin Resistance [Graphic Above]: Increasing fat accumulation in your abdomen [midsection] leads to a vicious-cycle where the fat cells of the central abdomen produce inflammatory cytokines such as interleukin-6 [IL6]. Eating plan: Avoiding inflammatory foods is important because the inflammation interferes with how leptin functions in the body. Women suffering from PCOS often have insulin resistance in the background placing them at high risk for developing diabetes before they reach menopause.

One such condition is leptin resistance which contributes significantly to weight gain and ultimately diabetes. A lack of physical activity increases the likelihood of leptin resistance as cortisol levels rise. C-reactive protein is a byproduct of inflammation causing foods and sets the stage for leptin resistance. With a few key lifestyle changes, control over proper leptin function in the body can be regained and the road to great health will transform from a weeded path to a super highway. It most certainly does not have to be like this, however, and once recognized for what it is, reversing leptin resistance becomes a manageable and beneficial endeavor.
When leptin is working properly in the body it helps to control how much is consumed at meals, which facilitates proper weight management and blood sugar regulation. Exercise helps to mitigate the effects cortisol has on the body and decrease resistance to leptin.
For sure Irvingia is no magic bullet but should be used as an adjunct to a healthy lifestyle that promotes weight loss and increases leptin sensitivity.

Cortisol also directly interferes with how leptin functions, making the body less sensitive to the leptin. CRP-Bound Leptin cannot cross the Blood Brain Barrier [BBB] and as a result cannot suppress appetite. Often we find ourselves consuming simple carbohydrates and other highly processed foods that suppresses or usurps leptin’s ability to decrease our appetite and this is when the trouble begins.
In addition to simple carbs and over consumption, chronic stress and sedentary lifestyles also increase resistance to leptin.

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