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Researchers believe a combination of physical and mental health problems can lead to dysfunction and breakdown of the gastrointestinal lining that leads to the development of IBS and various Gastrointestinal disorders.
A leaky gut is almost always associated with autoimmune disease (including Rheumatoid Arthritis), hence reversing an autoimmune disease also depends on the healing of the lining of the gastrointestinal tract.
This gut-joint axis is likely the same mechanism as the gut-brain axis or the gut-skin axis that produce the myriad of symptoms and diseases we are now seeing.
With my RA diagnosis, I gradually came to understand how gastrointestinal health in general, and Leaky Gut Syndrome in particular, contributes to many seemingly unrelated symptoms. When damage occurs to the mucosal barrier of the gut lining, we are increasingly losing a huge part of our immune system that works hard to fight off new invading molecules or proteins.
In RA, it is commonplace that the drugs used to relieve pain and inflammation can further damage the gut lining, even as quick as two weeks of consumption of those rheumatoid drugs.
At the moment, the precise role of Leaky Gut Syndrome in RA remains unclear, but it appears to be part of a vicious cycle that makes the condition worse from time to time. Unless specifically investigated, the role of altered intestinal permeability in patients with Leaky Gut often goes unnoticed.
Intestinal Barrier Function Test that can be ordered from BioHealth Diagnostics – This test analyzes saliva or blood serum sample for an assessment of the integrity of the gut’s mucosal barrier, antigen penetration, dysbiosis, leaky gut, mal-absorption, dietary protein sensitivity, intestinal permeability, etc.
Therefore, if you wish to reverse RA, you must also learn to address the causes of your Leaky Gut Syndrome at its sources and target treatments which usually require several components including avoidance of enterotoxic drugs, allergic foods, elimination of infections and bacteria overgrowth, nutritional dietary supplements and so forth. Foods high in sugar and processed carbohydrates increase the number and variety of different strains of Candida in the body.В  These foods also promote the growth of parasitic microbes and worms in the gut environment.

A diet high in fermented veggies and drinks such as coconut water kefir, ginger beer, raw sauerkraut, kombucha and kimchi help restore microbial balance.  Fermented, raw dairy from organic grass-fed cows and goats can be outstanding for gut health. Including lots of prebiotic rich foods such as asparagus, leeks, carrots, garlic, onions, radishes, jerusalem artichoke and jicama will help to strengthen your gut flora. Intermittent fasting for periods of 12 – 24 hours daily can be especially beneficial for regulating the gut flora.  These fasting periods should include lots of fluids and fermented drinks that bring enzymes, probiotics and organic acids into the gut environment. Longer cleansing periods with fermented drinks are recommended from time to time.  This cleansing process is extremely important for individuals suffering with disorders involving chronic gut inflammation.
To begin with, it is a pathological condition that occurs as part of many different diseases and syndromes.
What temporary symptomatic relief RA patients find from drugs, the mainstay of treatment, often comes at the price of damaging health with pharmaceutical side effects. The Leaky Gut Syndrome, through increased permeability of the intestinal lining, triggers inflammation of gut lining when our immune system begins invading altered molecules that pass through this gut lining to get access to our immune system. With an over-active immune system, the microvilli of the gut lining becomes damaged, our ability to properly digest food is hence lost, and harmful pathogens can flourish on these undigested food proteins and crowd out beneficial bacteria, resulting in an imbalance in our gut flora. The relationship between food allergies or intolerance and leaky gut is complex and circular.
The metabolic demand of a normally rapid cell turnover (usually 3 to 6 days) must be met if healing of damaged gut lining is to occur; but when these are not met due to mal-absorption of nutrients, hyperpermeability will exacerbate. If the signs and symptoms of Leaky Gut are ignored or unrecognized, it promotes continual damage to happen further and eventually, the overwhelmed immune system will start attacking other tissues and organs resulting in other forms of autoimmune diseases.

While it is not necessary for clinical tests of proving the presence of Leaky Gut Syndrome in patients with RA (since predominantly, RA patients are almost always likely to suffer from Leaky Gut), there are safe, non-invasive and affordable lab tests for measuring the small intestinal permeability available in the market.
Effects of probiotics on gut microbiota: mechanisms of intestinal immunomodulation and neuromodulation. Autoimmune diseases, gastrointestinal disorders and the microbiome in schizophrenia: more than a gut feeling. As leaky gut syndrome connects apparently unrelated disorders, it is one of the most misunderstood concepts today. The level of measured antibodies will be able to determine the stage of Leaky Gut Syndrome in the body.
The researchers at the University of Oslo, Norway, looked at food-related antibodies that show up in the gut rather than blood of people with RA.
This abnormally large spaces present between the cells of the gut wall allow passage of toxic materials, bacteria, fungi, parasites, undigested protein, fat and other waste not normally absorbed into the bloodstream in the healthy state.

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