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Histamine is a chemical involved in your immune system, proper digestion, and your central nervous system.
Histamine causes your blood vessels to swell, or dilate, so that your white blood cells can quickly find and attack the infection or problem. Because it travels throughout your bloodstream, histamine can affect your gut, lungs, skin, brain, and entire cardiovascular system, contributing to a wide range of problems often making it difficult to pinpoint and diagnose. In addition to the histamine produced inside your body, there are also a variety of foods that naturally contain histamine, cause the release of histamine, or block the enzyme that breaks down histamine, diamine oxidase.
Although histamine blockers, a class of acid-reducing drugs, seem like they would help prevent histamine intolerance, these medications can actually deplete DAO levels in your body. Remove the above high histamine foods for 30 days and reintroduce them one at a time by following the guidelines in my comprehensive elimination diet eCourse.
If testing is unavailable to you, you could simply try a diet low in histamine and add DAO supplementation at each meal. My ongoing research of allergy and autoimmune disease has uncovered a long history of medical manipulations that defy logic.
A food allergy reaction sends someone to the emergency room every 3 minutes.В Millions more can experience thisВ anaphylactic shockВ from medication, insect venom, and even latex.
People who are unable to effectively metabolize histamines must restrict their consumption of many foods that I typically recommend on a regular basis.
I always wondered about what was happening with individuals who told me they were “allergic to the sun.” Interesting research is indicating this is a histamine response as UV light can trigger histamine release (2).
Histamine only becomes a problem when we have metabolic disturbances that do not allow us to effectively metabolize histamine properly.
The experts state that DAO is the major enzyme involved in histamine metabolism (6). The enzyme converts the histamine into imidazole acetaldehyde which does not trigger any sort of reaction in the body. Small Intestinal Bacterial Overgrowth (SIBO) – some gut microbes produce high amounts of histamines as a byproduct of their metabolism. According to available research, histamine intolerance manifests in approximately 3% of the population (9).
The three biggest factors involved with histamine intolerance include leaky gut syndrome or related disorders such as Crohn’s disease, Irritable bowel, celiac, gluten sensitivity, etc (11).
Most doctors are not familiar with histamine intolerance and never consider this as a contributing factor in the individual’s health challenges. Research has shown that people react quite differently to elevated histamine making it that much harder to pinpoint (12).
Histamines travel throughout the bloodstream and therefore can effect the gut, lungs, skin, brain and entire cardiovascular system. Without getting the blood test you could do a histamine challenge by consuming a number of different fermented foods and high histamine foods and see if this aggravates your symptoms. To improve your tolerance to histamine, it is critical to heal the gut and address the dysbiotic issues that are at the root of the problem.

Some foods naturally have more histamine content while others accumulate histamines while they age. These foods do not necessarily contain histamine but they block the action of DOA and therefore they potentiate the effects of elevated histamines. People with histamine intolerance react in a multitude of different ways.В (19)В Some people cannot handle any high histamine foods while others can handle certain types but not others.
Overtime, as histamine content is reduced and the individual improves their gut health, reduces inflammation, improves liver function and stabilizes their adrenals they will be able to handle more of the histamines. If you struggle with major symptoms listed above when you have the various high histamine foods you may have this problem. If you are suffering from an acute histamine reactions, taking 2 caps of Allergy DefenseВ every hourВ and taking DAO enzymes or high dose proteolytic enzymes can help to reduce the effects of this.
I’m in my early thirties and allergic to latex fruits like avocado, banana, and kiwi.
If you’ve suffered from seasonal allergies or food allergies, you may have noticed that antihistamine medications like Zytrec, Allegra or Benedryl provide quick relief of your symptoms. The histamine buildup is what gives you a headache and leaves you feeling flushed, itchy and miserable. Histamine in the central nervous system is broken down primarily by histamine N-methyltransferase (HMT), while histamine in the digestive tract is broken down primarily by diamine oxidase (DAO). Even my seasonal allergies have been quelled with homeopathic dilutions of dust, mold, and pollen.
If you have a histamine intolerance consuming histamine rich foods can lead to chronic health issues such as allergies, asthma, sinus problems, eczema, chronic pain, menstrual problems and much more (1). Individuals with periods of highВ estrogen may have higher than normal histamine responses and high stress increases histamine levels and decreases the bodies ability to metabolize the histamine (4, 5).
DAO is responsible for ensuring a steady histamine level required for the balance of numerous chemical reactions taking place in the body. A homozygous DAO would make someone more susceptible to developing a histamine intolerance. Amy Myers MD, “histamine blockers, a class of acid-reducing drugs, seem like they would help prevent histamine intolerance, these medications can actually deplete DAO levels in your body” (8). These symptoms will last until the body metabolizes the histamines and removes them from the system. In up to 20% of these cases the symptoms occur mostly when histamine containing foods are used in combination with DAO inhibitors such as alcohol. The first is that there are so many popular foods, many of which are considered health foods that are high in histamines. In fact, many physicians including myself, typically recommend a diet high in histamine containing foods. As a clinician, I have learned that when individuals react very poorly to fermented foods it is a sign of histamine intolerance.

When an individual has a homozygous mutation they will most likely struggle with histamine metabolism. If so, try a low-histamine diet for a week and if you notice significant improvements you most likely have histamine intolerance.
For some, this will mean they will be able to incorporate small amounts of all the higher histamine foods. In particular, if you struggle with fermented foods and probiotic supplements that is a classic sign of histamine intolerance.
Ultraviolet B (UVB) light-induced histamine release from rat peritoneal mast cells and its augmentation by certain phenothiazine compounds. This is because histamine’s role in the body is to cause an immediate inflammatory response. This is part of the body’s natural immune response, but if you don’t break down histamine properly, you could develop what we call histamine intolerance.
You might be wondering now what on earth you CAN eat, so I’ve made a list of low histamine foods as well. Though both enzymes play an important role in histamine break down, theВ American Society for Clinical NutritionВ found that DAO is the main enzyme responsible for breaking down ingested histamine. Allergy immunotherapy is intriguingly similar, exposing us to daily, increasing amounts of allergens that slowly reprogram our immune system. Approximately 80% of individuals with histamine intolerance are women and most of them are over 40 (10). This includes fermented foods which have incredible health benefits for those with adequate histamine metabolism. A low histamine diet must be focused around getting foods at their peak level of freshness.
I don’t have any of the symptoms on the above list, but I’ve heard people relate my allergy to histamines! Individuals with histamine intolerances often break out with hives, eczema, rashes, puffy eyes, headaches, etc. If you answered yes to any of these questions, then you could have a histamine intolerance. In this case, I suggest readingВ my post on healing the gut,В and over time you should be able to stop the DAO and go back to eating histamine-containing foods.

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