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The American Dietetic Association says there's no conclusive evidence that diet sodas directly cause weight gain, but at least one expert believes an artificial sweetener habit may overstimulate our taste receptors for sweetness. Of course, it’s possible that if people in the studies who drank diet soda didn’t do so, they might have gained even more weight, especially if instead they turned to sugary beverages or consumed food instead of the diet soda. So, if you're used to drinking lots of sugary beverages, replacing them with a calorie-free soda might help kickstart weight loss. As a substitute for diet soda, Ludwig suggests plain or mineral water, or coffee or tea made with up to 1 gram of sugar per ounce (or 2 teaspoons per 8 ounce cup).
Besides the fact that diet soda causes dehydration, weight gain, mineral depletion, diabetes and caffeine addiction, new research shows they're also responsible for an increased risk of vascular events such as stroke, heart attack, and vascular death. Soft drinks account for more than a quarter of all drinks consumed in the United States. In the current climate of escalating obesity rates, artificially sweetened soft drinks are marketed as healthier alternatives to sugar-sweetened beverages, due to their lack of calories. Gardener and team examined the relationship between both diet and regular soft drink consumption and risk of stroke, myocardial infarction (or heart attack), and vascular death. They found that those who drank diet soft drinks daily were 43 percent more likely to have suffered a vascular event than those who drank none, after taking into account pre-existing vascular conditions such as metabolic syndrome, diabetes and high blood pressure. Scientists at Boston University’s medical school say people who drink more than one regular or diet soda each day develop the same risks for heart disease. The implied promise, of course, has been that diet soft drinks should help people lose or maintain their weight.
Finally, they conducted an experiment with five men and two women who did not usually consume drinks or foods with artificial sweeteners.
Soft drinks also displace mineral-rich foods, and the high-phosphorus American diet specifically reduces calcium absorption, which affect bone development and strength.[viii][ix] [x] [xi] The problem is compounded by acid-blocking drugs, which are taken by millions of people. Low potassium and the consequential fatigue become most noticeable in people who consume large amounts of soft drinks, particularly colas.

Take a look at the ingre­di­ents of Diet Coke or another major brand of diet soda, and you’ll find a list of syn­thetic chem­i­cals that couldn’t pos­si­bly be good for kids.
Caramel color:В It sounds innoВ­cent enough, but the caramel color added to many cola drinks may conВ­tain a susВ­pected carВ­cinoВ­gen called MEI-4.
Phos­phoric acid: Used to give a tangy fla­vor to diet colas, phos­phoric acid is a cor­ro­sive chem­i­cal that can dam­age tooth enamel, and has been linked to chronic kid­ney dis­ease and lower bone density. While more research is appar­ently needed to make any defin­i­tive con­clu­sions, I believe that there are enough ques­tion marks to jus­tify keep­ing diet sodas out of our schools. While I love soda, I agree that we shouldn’t be flood­ing our schools with it, espe­cially not diet soda, which has been proven to be par­tic­u­larly dan­ger­ous.
Someone bellies up to the fast food counter and orders a Whopper with cheese, large fries  and diet soda — as if a zero-calorie chaser can compensate for the 1,300 calorie overload.
Normal weight people who drank 3 servings or more of diet soda a day — at least 21 weekly servings — were at almost double the risk for becoming overweight or obese after seven to eight years compared to people who skipped diet drinks, according to researchers at the University of Texas Health Science Center at San Antonio. And if you eat a basically healthful diet with minimal amounts of sugary foods or artificial sweeteners, enjoying an occasional or even daily diet soda won't likely tip the scale.
But because emerging research suggests possible links between diet soda and metabolic syndrome, type 2 diabetes, kidney problems, and preterm delivery, it’s prudent if you’re more than an occasional diet soda consumer to curb intake.
New research shows that the artificial sweeteners are not inert, and diet soft drinks are no better than those loaded with sugars.
So when a person consumes a diet soft drink, the insulin gets ready to convert whatever food that follows to fat.
It turns out that large amounts of glucose or fructose (found in sugary drinks) or caffeine (found in colas and some noncola drinks) deplete potassium. Increasing dietary phosphorus intake from food additives: potential for negative impact on bone health. Accord­ing to a recent paper from researchers at Pur­due Uni­ver­sity, diet soda made with arti­fi­cial sweet­en­ers trick the body into think­ing that it is con­sum­ing real food and sugar even though it isn’t, which could lead to meta­bolic con­fu­sion and over-consumption of calo­ries. And in a new study pub­lished in the Amer­i­can Jour­nal of Pub­lic Health, researchers from Johns Hop­kins Bloomberg School of Pub­lic Health found that diet soda drinkers con­sume more total calo­ries than sweet­ened cola drinkers.

In a Jan­u­ary 2014 Con­sumer Reports study, 12 out of 81 brands of soft drinks tested (includ­ing Diet Pepsi) con­tained MEI-4 at scary-high lev­els (more than 29 micro­grams per serving)–enough to poten­tially carry a can­cer warn­ing label in the state of Cal­i­for­nia. And diet sodas per­pet­u­ate the habit of need­ing every­thing to be sweet, even what we drink.
And people who consumed at least one daily serving of diet soda (versus none) were more likely to develop a high waist circumference, a condition linked with diabetes, hypertension and cardiovascular disease, according to a recent study. David Ludwig, director of the Optimal Weight for Life Program at Children’s Hospital in Boston, cites animal studies that suggest consuming diet drinks alone (not with food) can confuse or disrupt the body’s ability to determine calorie content based on sweetness.
I try to drink a cup of water before I have any diet soda and buy one can at a time — instead of a 6-pack or case —  to have at home or at my office. The researchers looked at how often individuals drank soft drinks -- diet and regular -- and the number of vascular events that occurred over a ten-year period. People who regularly consumed diet soft drinks had, on average, waistlines that were almost three times bigger than those who never consumed diet soft drinks. But please, the last thing we need to do is get kids hooked on arti­fi­cially sweet­ened soft drinks that offer no nutri­tional ben­e­fits and, over time, may be detri­men­tal to their health. I want to do some­thing to cry out that we do not want diet drinks in our schools but I don’t know where to start. But as we both know, arti­fi­cially sweet­ened “diet” drinks are just as bad, if not worse.

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