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Beta oxidation of unsaturated fatty acids ppt,need to lose weight in 4 weeks,paleo diet what foods to eat - Reviews

Fatty acids with an odd number of carbon atoms are oxidized by the pathway of ОІ-oxidation, producing acetyl-CoA, until a three-carbon (propionyl-CoA) residue remains. This compound is converted to Succinyl-CoA, a constituent of the citric acid cycle (figure-1). The propionyl residue from an odd-chain fatty acid is the only part of a fatty acid that is glucogenic. Vitamin B12 deficiency leads to impaired conversion of L-methyl malonyl co A to Succinyl co A, due to reduced activity of the enzyme, causing methyl malonic aciduria. In the oxidation of unsaturated fatty acids, most of the reactions are the same as those for saturated fatty acids, only two additional enzymes an isomerase and a reductase are needed to degrade a wide range of unsaturated fatty acids.


There is regulation at the level of entry of fatty acids into the oxidative pathway byВ carnitine palmitoyl transferase-IВ (CPT-I), CPT-I activity is low in the fed state, leading to depression of fatty acid oxidation, and high in starvation, allowing fatty acid oxidation to increase.
Malonyl-CoA, the initial intermediate in fatty acid biosynthesis (Figure-4), formed by acetyl-CoA carboxylase in the fed state, is a potent inhibitor of CPT-I. Thus,В ОІ -oxidation from free fatty acids is controlled by the CPT-I gateway into the mitochondria, and the balance of the free fatty acid uptake not oxidized is esterified. Figure-4- CPT-1 (Carnitine palmitoyl Transferase -1) is inhibited by malonyl co A, the product of first step of fatty acid synthesis. This only accumulates in tissues when the animals are suffering from essential fatty acid deficiency (see below).


Under these conditions, free fatty acids enter the liver cell in low concentrations and are nearly all esterified to acylglycerols and transported out of the liver in very low density lipoproteins (VLDL). Active fatty acid synthesis takes place in the well fed state under the effect of insulin, thus when fatty acid synthesis is active, fatty acid oxidation is inhibited.



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Comments to “Beta oxidation of unsaturated fatty acids ppt”

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