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Each year, someone writes a book scaring people about food and that gets covered in the New York Times and then a whole rash of junk science studies get produced affirming exactly what the book said. Most recently, mainstream media is at war with both sugar and wheat but it won't be long before the cycle swings back to artificial sweeteners again. The findings are contrary to some studies in humans and in animal models claiming more storage of fat and other negative effects. Co-author Dr Richard Young, Senior Postdoctoral Researcher in the University's Nerve-Gut Research Laboratory, says population-level studies have yet to agree on the effects of long-term artificial sweetener intake in humans. A good point and a general problem in this kind of 'epidemiology-as-sociology' study on all sides of the argument. She said: 'The elevated insulin response could be a good thing because it shows the person is able to make enough insulin to deal with spiking glucose levels.
But recent findings in animal studies suggest that some sweeteners may be doing more than just making foods and drinks taste sweeter.
It’s pretty clear that if we follow the example of our hunter gatherer ancestors, artificial sweeteners should not be part of contemporary Stone Age diets. In addition to these artificial sweeteners, the FDA has sanctioned a sugar substitute, stevia, as a dietary supplement since 1995. If you were to ask most people why they drink artificially sweetened beverages, the resounding answer would be to enjoy a sweet drink without all the drawbacks of sugar laden sodas.
A 2010 prospective study25 of 59,334 pregnant women from Denmark showed for the first time that consumption of artificially sweetened soft drinks significantly increased the risk for pre-term delivery (less than 37 weeks). Consumption of artificially and sugar-sweetened beverages and incident type 2 diabetes in the Etude Epidemiologique aupres des femmes de la Mutuelle Generale de l’Education Nationale-European Prospective Investigation into Cancer and Nutrition cohort. When that happens, they will not want to include a new study from the the University of Adelaide in Diabetes Care which found that artificially sweetened drinks produced no different response in the healthy human gut to a glass of water. However, a recent study has shown an increased risk of developing type 2 diabetes in regular and high consumers of artificially sweetened drinks. It’s this cumulative and growing body of research over decades that should instill complete confidence in consuming food and beverages containing low-calorie sweeteners. So despite no extra sugar being consumed, the artificial sweetener was related to an enhanced blood insulin and glucose response.Professor Yanina explained that they do not fully understand the implications that these rises could have.


In my book, The Paleo Diet Revised (2010)1 I warned against drinking artificially sweetened soft drinks and further strengthened my opposition to all artificial sweeteners in 2012 with The Paleo Answer.2 Over the past few years numerous epidemiological (population), animal, tissue and human studies have demonstrated the adverse health effects of these synthetic chemicals.
Rats allowed to eat their normal chow consumed more food and gained more weight when artificial sweeteners were added to their diet.34-43 The best available evidence indicates that artificial sweeteners when consumed by either laboratory animals or humans promote weight gain by altering the normal gut bacterial biome3, 45 which in turn adversely affects glucose and insulin metabolism and consequently appetite.
Exposure to non-nutritive sweeteners during pregnancy and lactation: Impact in programming of metabolic diseases in the progeny later in life.
The area under the curves for blood glucose, plasma insulin, 13CO2-to-12CO2 ratio, and T50 did not differ between the 4 study days before and after 75-g oral glucose (one-factor repeated-measures ANOVA). And, on top of this, more than 100 regulatory agencies approve these ingredients, and leading health organizations from the American Diabetes Association to the Academy of Nutrition and Dietetics also condone the use of low-calorie sweeteners.
Rather, the sweeteners react with receptors on the tongue to give people the sensation of tasting something sweet without the calories associated with natural sweeteners, such as table sugar. A particularly powerful study just published in the October 2014 issue of Nature3 provides a convincing argument against the use of artificial sweeteners in our food supply.
This study is important, because many people may consume much higher concentrations of this chemical by drinking artificially sweetened beverages on a daily basis for years and years. An interesting outcome of this study was that only artificially sweetened beverages increased the risk for pre-term delivery – and not sugar sweetened soft drinks.
Diet soda intake and risk of incident metabolic syndrome and type 2 diabetes in the Multi-Ethnic Study of Atherosclerosis (MESA).
Diet soft drink consumption is associated with an increased risk of vascular events in the Northern Manhattan Study.
Dietary intake and the development of the metabolic syndrome: the Atherosclerosis Risk in Communities study.
Association between sugar-sweetened and artificially sweetened soft drinks and type 2 diabetes: systematic review and dose-response meta-analysis of prospective studies. Consumption of artificially-sweetened soft drinks in pregnancy and risk of child asthma and allergic rhinitis.PLoS One.
Intake of artificially sweetened soft drinks and risk of preterm delivery: a prospective cohort study in 59,334 Danish pregnant women. Association between intake of artificially sweetened and sugar-sweetened beverages and preterm delivery: a large prospective cohort study.


Artificial sweeteners produce the counterintuitive effect of inducing metabolic derangements.
General and persistent effects of high-intensity sweeteners on body weight gain and caloric compensation in rats. Adverse effects of high-intensity sweeteners on energy intake and weight control in male and obesity-prone female rats.
Effects of artificial sweeteners on insulin release and cationic fluxes in rat pancreatic islets.
Experience with the high-intensity sweetener saccharin impairs glucose homeostasis and GLP-1 release in rats. In our most recent study involving healthy men, we found that the gut's response to artificially sweetened drinks was neutral – it was no different to drinking a glass of water. If you consume artificial sweeteners in the form of sodas or foods once in a blue moon, they will have little or no adverse effects upon your long term health. Aspartame was sanctioned for use as a sweetener by the FDA in 1996, followed by sucralose (1999), neotame (2002), and acesulfame (2003). Frequently, it is difficult to translate results from animal experiments into, meaningful recommendations for humans, because large epidemiological studies generally don’t show artificial sweeteners to be risk factors for cancer.
You may think that anytime chemical additives such as artificial sweeteners were permitted into our food supply, they would have been thoroughly tested and conclusively shown to be safe.
Rayner, MBBS, PHD, 'Artificial Sweeteners Have No Effect on Gastric Emptying, Glucagon-Like Peptide-1, or Glycemia After Oral Glucose in Healthy Humans', Diabetes Care December 2013 vol. But these studies indicate that sugar sweetened drinks may be less harmful to your developing fetus than are artificially sweetened soft drinks. In obese people without diabetes we have shown sucralose is more than just something sweet that you put into your mouth with no other consequences.'She said further studies are needed to learn more about the mechanism through which sucralose may influence glucose and insulin levels, as well as whether those changes are harmful.



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