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Amyotrophic Lateral Sclerosis (ALS), also known as Lou Gehrig’s disease, is a progressive, neuro-degenerative disease that affects nerve cells in the brain and the spinal cord. ALS is often called Lou Gehrig's Disease, after the famous baseball player who was diagnosed with it in 1939. The Registry is collecting critical information about the disease that will improve care for people with ALS and help us learn what causes the disease, how it can be treated and even prevented.
The motor neuron disease, Amyotrophic Lateral Sclerosis (ALS), or Lou Gehrig's disease, is a devastating illness. Clinical features of Lou Gehrig's disease include the most common symptom, muscle atrophy, which is a major symptom of the disease. Understandably, people tend to freak out when they get the idea that the symptoms they are experiencing might be a prelude to Lou Gehrig's disease, but often the symptoms are caused by something else. On a weekly basis, any neurologist will see patients that are afraid they have Lou Gehrig's disease. In fact, at any given time, there are probably more people who fear they have ALS than people that actually have ALS. On this website, I will elaborate a bit about Lou Gehrig's disease and hopefully provide some decent information about ALS symptoms, Lou Gehrig's disease statistics, and Lou Gehrig's disease treatment.
A tiny fraction, 0.03 %, of those diagnosed with Lou Gehrig's disease are younger than 38 or older than 92 at the time of diagnosis. Unfortunately, the distribution of Lou Gehrig's disease incidences within age groups is not entirely normally distributed, so the number of people getting ALS in their thirties may be higher. It is difficult (almost impossible) to say how old people are, on average, if they are diagnosed with ALS.
Sometimes Lou Gehrig's disease patients who are diagnosed with the disease can suddenly go into remission after the diagnosis. Only one drug (riluzole) has so far been used in order to directly prolong the lifespan of patients with amyotrophic lateral sclerosis (Lou Gehrig's disease). Most of the treatment around Lou Gehrig's disease patients revolves around relieving symptoms and improving the quality of life. Two-thirds of patients with Lou Gehrig's disease complain about pain normally caused by muscle cramps, fasciculations, and spastic movements of limbs. Scientists have been trying for years to find a cure for Lou Gehrig's disease or new ways to delay the progression of the disease—besides symptomatic treatment, of course. In a meta analysis study, it was investigated if antioxidants could prolong the lifespan of ALS patients. The most common symptom of Lou Gehrig's disease (ALS) is muscle weakness or muscle atrophy. When people are seeking a neurologist and they mention Lou Gehrig's disease before the consultation, muscle weakness is the first thing the neurologist will look for as to exclude Lou Gehrig's disease immediately. It is very rare that people are diagnosed with Lou Gehrig's disease without having muscle weakness, a reason why weakness and atrophy should be in capital letters and in bold in any list of Lou Gehrig's disease symptoms (see below).
If you are on this webpage because you fear that you have ALS, but you do not have any weakness or any atrophy in any of your limbs and are younger than 40 years old, you most likely do not have Lou Gehrig's disease! Ethnicity is an important factor when analyzing statistics on Lou Gehrig's disease (ALS) data because some studies suggest that ethnic background may modify predisposition to Lou Gehrig's disease.

Most studies on Caucasian populations have shown an incidence of Lou Gehrig's disease above 1 per 100,000 person years.
According to studies based on other ethnic populations, the incidence of Lou Gehrig's disease is lower among non-Caucasian populations. It is more relevant to look at incidence rates for those age groups affected by Lou Gehrig's disease and not just total populations.
The study showed incidence rates of Lou Gehrig's disease in some of the world's largest countries (table 1).
Regardless, data was analyzed, and it showed that the overall mortality from Lou Gehrig's disease in the United States is 1 per 100,000 a year.
Amyotrophic lateral sclerosis (ALS), or Lou Gehrig’s Disease, has gotten some serious attention after Pete Frates and his family started the ALS Ice Bucket Challenge to raise money for and awareness of the incurable neurodegenerative disease.
The ALS Association explains that ALS degenerates motor neurons used to control muscle movements, meaning the brain can’t send messages to muscle fibers in order to move them.
According to the ALS Association, the degeneration of motor neurons prevents impulses from being sent to muscle fibers that cause muscle movement.
There’s currently no cure for ALS, although the FDA has approved one drug that helps slow the progression of the disease, according to the ALS Assocation. According to The National Center for Biotechnology Information, Jean-Martin Charcot described and diagnosed the first cases of ALS in studies conducted from 1865 to 1869.
ALS Ice Bucket Challenge: 5 Fast Facts You Need to KnowThe ALS Bucket Challenge, in honor of former BC baseball captain Pete Frates, is a campaign to raise money for ALS, also known as Lou Gehrig's disease, which affects the nerve cells in the brain and spinal chord. ALS is one of the most common neuromuscular diseases worldwide, and people of all races and ethnic backgrounds are affected.
The familial form of ALS usually results from a pattern of inheritance that requires only one parent to carry the gene responsible for the disease. ALS is one of the major neurodegenerative diseases alongside Parkinson's disease and Alzheimer's disease. Ninety to ninety-five percent of those diagnosed with Lou Gehrig's disease have the sporadic form, while 5-10 % of all incidences have a record of the disease in their families. The most common symptoms of stress leading people to think of Lou Gehrig's disease and Parkinson's are tremors and cramps. An example is the postulate that the average age for people being diagnosed with Lou Gehrig's disease is 65, and the standard deviation is nine years.
The chance of being stressed or something else leading one to think about Lou Gehrig's disease or a similar diseases before the age of 38 is of course much higher.
Exposure to heavy metals and the incidence rate of Lou Gehrig's disease is also something which has been studied extensively in Japan. Comparing this number to the age distribution numbers shortly outlined will tell us that the chance of getting Lou Gehrig's disease any particular year, when you are younger than 38, is about 1:165,000,000. The real numbers surrounding the actual number of people getting Lou Gehrig's disease and the risk of getting Lou Gehrig's disease must be found in peer reviewed journals. In the section about treatment, some of the methods to improve life-quality of ALS patients are discussed. Some of those videos are very informative and excellent for both sufferers and people related to Lou Gehrig's disease patients.

However, it is widely accepted that the incidence of Lou Gehrig's disease is uniform across populations of Caucasian origin or most people in Western Europe and North America (USA and Canada). In other words, each year there is on average a 1:100,000 chance of getting Lou Gehrig's disease.
This can, however, be disputed as the criteria of diagnosis and the frequency of which Lou Gehrig's disease cases are reported may be different in some of those countries.
This seems reasonable as the vast majority of people diagnosed with Lou Gehrig's disease fall under this age range. The life-expectancy following diagnosis depends on a number of factors, such as age and physical condition. In some cases, the cause of death is registered as something else than Lou Gehrig's disease—even though the condition was caused by Lou Gehrig's disease.
As a result, early symptoms of ALS include varying kinds of muscle weakness, typically involving the arms and legs, as well as difficulties swallowing, speaking and breathing. The fear of having such a crippling disease can add to the patient's stress levels, causing distress and preventing people from leading healthy lives.
The symptoms above can also be caused by other diseases more serious than BFS but still not be Lou Gehrig's disease. In fact, people in their thirties are often very busy with jobs, etc., compared to both older and younger people. Lithium was shown to induce neuronogenesis (genesis of new neurons) and remove mitochondria altered by the disease.
Age is perhaps the most important factor of the two, due to younger individuals generally being in better health and ability to fight disease for a longer time compared to the elderly. It did, however, consider the mortality from Lou Gehrig's disease—that is, the incidence of death from Lou Gehrig's disease. ALS impacts the body’s ability to perform voluntary movements, which includes breathing, since people are able to hold their breath. ALS is still referred to as Charcot’s disease in many parts of the world, The National Center for Biotechnology Information reports. Upwards of 30,000 Americans have ALS at one time and the disease typically affects people ages 40 to 70. In the section about symptoms, a more detailed description of Lou Gehrig's disease symptoms can be found.
The ALS Association adds the limbs of ALS patients tend to look thinner as their muscles atrophy. Charcot is also credited as the founder of multiple sclerosis and the study of modern neurology.
The ALS Assocation said there are several drugs currently in clinical trials that hold promise in terms of fighting the disease.
Wallace, Senator Jacob Javits and Sesame Street creator Jon Stone, according to the ALS Association.

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