Oral herpes virus treatments,herpes labialis treatment aafp,complementary alternative medicine for depression,cancer treatments for colon cancer - For Begninners

admin | Category: Oral Herpes Treatment At Home | 26.07.2014
A cross-sectional study of herpes simplex virus types 1 and 2 in college students: occurrence and determinants of infection. Longitudinal evaluation of herpes simplex virus DNA load during episodes of herpes labialis.
The natural history of recurrent herpes simplex labialis: implications for antiviral therapy. Comparison of Chemicon SimulFluor direct fluorescent antibody staining with cell culture and shell vial direct immunoperoxidase staining for detection of herpes simplex virus and with cytospin direct immunofluorescence staining for detection of varicellazoster virus.
Acute herpetic gingivostomatitis in adults: a review of 13 cases, including diagnosis and management.
Treatment of herpes simplex gingivostomatitis with aciclovir in children: a randomised double blind placebo controlled study. Interventions for the prevention and treatment of herpes simplex virus in patients being treated for cancer. Single-dose, patient-initiated famciclovir: a randomized, double-blind, placebo-controlled trial for episodic treatment of herpes labialis.
Valacyclovir and topical clobetasol gel for the episodic treatment of herpes labialis: a patient-initiated, double-blind, placebo-controlled pilot trial. Clinical efficacy of topical docosanol 10% cream for herpes simplex labialis: a multi-center, randomized, placebo-controlled trial. Acyclovir cream for treatment of herpes simplex labialis: results of two randomized, double-blind, vehicle-controlled, multicenter clinical trials. Vanilla contains anti infection properties, which helps to get rid of the viral infection quickly.
You need to change the toothbrush whenever the inflamed blister has formed & again after it cleared up, as toothbrush can easily spread the virus. Lysine, an amino acid which is available either as oral supplement or as cream will help to get rid of the problem.
Avoid taking food that is high in arginine, which is a protein that helps the herpes virus by building blocks to spread it. Take an oral antiviral medication like penciclovir, acyclovir or famciclovir, which speed up the healing & reduces the severity of the outbreaks.
Eyes: The herpes virus can even affect the eyes by causing pinkeye (conjunctivitis), when you place your finger after touching the affected part.
HighlightsHerpes VirusesHerpes simplex virus 1 (HSV-1) is the main cause of herpes infections that occur on the mouth and lips.
TransmissionTo infect people, the herpes simplex viruses (both HSV-1 and HSV-2) must get into the body through tiny injuries in the skin or through a mucous membrane, such as inside the mouth or on the genital area. Unfortunately, only 5% of infected pregnant women have a history of symptoms, so in many cases herpes infection is not suspected, or symptoms are missed, at the time of delivery. Eczema HerpeticumA form of herpes infection called eczema herpeticum, also known as Kaposi's varicellaform eruption, can affect patients with skin disorders and immunocompromised patients. Herpes in Patients with Compromised Immune SystemsHerpes simplex is particularly devastating when it occurs in immunocompromised patients and, unfortunately, co-infection is common. The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. Cold sores (oral herpes simplex), flu, and other diseases are contracted through kissing, etc. More than half of American young people are infected with oral herpes simplex virus or cold sores (percentage of those infected increasing with age usually due to kissing). Wozniak MA, Shipley SJ, Combrinck M, Wilcock GK, Itzhaki RF (2005) Productive herpes simplex virus in brain of elderly normal subjects and disease patients.
The virus travels from the skin during contact to the sensory dorsal root ganglion, where latency is established. The mouth lesions (herpetic gingivostomatitis) consist of painful vesicles on a red, swollen base that occur on the lips, gingiva, oral palate, or tongue. However, if the pattern of the lesions is not specific to HSV, its diagnosis can be made by viral culture, PCR, serology, direct fluorescent antibody testing, or Tzanck test.
In one randomized controlled trial (RCT), children receiving acyclovir had oral lesions for a shorter time than children receiving placebo (median of four versus 10 days). Glycyrrhizic acid present in licorice will helps to stop the cold sore virus cells to spread & reduces it to recur again. It’s recommended to wash your hands frequently or especially when your touch your cold sore or around the affected area, for not to spread the virus all over the body.
So, due to weak immune system, the herpes virus can also affect the other organs of the body like lungs, liver, brain, etc. Both viruses can be carried in bodily fluids (such as saliva, semen, or fluid in the female genital tract) or in fluid from herpes sores. If there is evidence of an active outbreak, doctors usually advise a Cesarean section to prevent the baby from contracting the virus in the birth canal during delivery.Approach to the Pregnant Herpes Patient. The infection may recur after treatment has been stopped and, even during therapy, a patient can still transmit the virus to another person. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions.
The diagnosis of an infection with herpes simplex virus type 1 is usually made by the appearance of the lesions (grouped vesicles or ulcers on an erythematous base) and patient history. Oral HSV-1 infections reactivate from the trigeminal sensory ganglia, affecting the facial, oral, labial, oropharyngeal, and ocular mucosa.Primary infection appears two to 20 days after contact with an infected person. The risk for infection is highest with direct contact of blisters or sores during an outbreak.Once the virus has contact with the mucous membranes or skin wounds, it begins to replicate.
Drugs can, however, reduce symptoms and improve healing times.Acyclovir and Related DrugsAntiviral drugs called nucleosides or nucleotide analogues are the main drugs used to treat genital herpes. It serves little purpose to ask someone if they have oral herpes before kissing or intimate contact since blisters do not even need to be present for you to get the cold sore disease.
However, if uncertain, the diagnosis of herpes labialis can be made by viral culture, polymerase chain reaction, serology, direct fluorescent antibody testing, or Tzanck test.
The virus is then transported within nerve cells to their roots where it remains inactive (latent) for some period of time.
Other nonoral herpes simplex virus type 1 infections include herpetic keratitis, herpetic whitlow, herpes gladiatorum, and herpetic sycosis of the beard area.
The swab should be sent in special viral transport media directly to the laboratory (or placed on ice if transport will be delayed).
Usually cold sores can spread from one person to another person by close personal contact like kissing, oral sex etc. Samples are cultured to detect the virus at 3 - 5-day intervals prior to delivery to determine whether viral shedding is occurring.
The plague-like spread of the cold sore virus is largely due to misinformation and the irresponsible, 'romantic' glorification of mouth-to-mouth kissing in movies, tv, and other media, and even other health websites.
The differential diagnosis of nongenital herpes simplex virus infection includes aphthous ulcers, acute paronychia, varicellazoster virus infection, herpangina, herpes gestationis (pemphigoid gestationis), pemphigus vulgaris, and Behcet syndrome. If no lesions are present and cultures indicate no viral shedding, a vaginal delivery can be performed and the newborn is examined and cultured after delivery.Some doctors recommend anti-viral medication for pregnant women who are infected with HSV-2. Iridocyclitis is another serious complication of ocular herpes, in which the iris and the area around it become inflamed.GingivostomatitisHerpes can cause multiple painful ulcers on the gums and mucous membranes of the mouth, a condition called gingivostomatitis. Oral acyclovir suspension is an effective treatment for children with primary herpetic gingivostomatitis.


Usatine, MDFigure 2.Primary herpetic gingivostomatitis caused by herpes simplex virus type 1 shown in (A) a four-year-old girl with lower lip ulcers and crusting on the upper lip, and (B) a two-year-old girl with ulcers on the lower lip and tongue. During shedding, the virus can infect other people through exchange of bodily fluids.Sometimes, infected people can transmit the virus and infect other parts of their own bodies (most often the hands, thighs, or buttocks).
Recent studies indicate that acyclovir (Zovirax, generic) valacyclovir (Valtrex), or famciclovir (Famvir) can help reduce the recurrence of genital herpes and the need for Cesarean sections. Untreated, this condition can be extremely serious and possibly fatal.Ocular Herpes and Vision LossHerpetic infections of the eye (ocular herpes) occur in about 50,000 Americans each year. Oral acyclovir, valacyclovir, and famciclovir are effective in treating acute recurrence of herpes labialis (cold sores). A Tzanck test is difficult to perform correctly without specific training in its use, but it may be done in the office setting by scraping the floor of the herpetic vesicle, staining the specimen, and looking for multinucleated giant cells.
This process, known as autoinoculation, is uncommon, since people generally develop antibodies that protect against this problem.Transmission of Oral Herpes. In most cases, ocular herpes causes inflammation and sores on the lids or outside of the cornea that go away in a few days.
Recurrences of herpes labialis may be diminished with daily oral acyclovir or valacyclovir. Usatine, MDIn recurrent herpes labialis, symptoms of tingling, pain, paresthesias, itching, and burning precede the lesions in 60 percent of persons.5 The lesions then appear as clusters of vesicles on the lip or vermilion border (Figure 1). HSV is part of a group of other herpes viruses that include human herpes virus 8 (the cause of Kaposi's sarcoma) and varicella- zoster virus (also known as herpes zoster, the virus responsible for shingles and chicken pox).
However, other conditions can resemble herpes, and doctors cannot base a herpes diagnosis on visual inspection alone. For a recurrent episode, treatment takes 1 - 5 days depending on the type of medication and dosage.To suppress outbreaks, treatment requires taking pills daily on a long-term basis. Topical acyclovir, penciclovir, and docosanol are optional treatments for recurrent herpes labialis, but they are less effective than oral treatment. HSV-1 is the most prevalent form of herpes simplex virus, and infection is most likely to occur during preschool years. Neonatal herpes can spread to the brain and central nervous system, causing encephalitis and meningitis and can lead to intellectual disability, cerebral palsy, and death. In addition, many patients who carry the virus do not have visible genital or oral lesions.
Acyclovir and famciclovir are taken twice a day, valacyclovir once a day.Suppressive treatment can reduce outbreaks by 70 - 80%.
Nongenital herpes simplex virus type 1 (HSV-1) is a common infection that most often involves the oral mucosa or lips (herpes labialis).
Herpes can also spread to internal organs, such as the liver and lungs.Infants infected with herpes are treated with acyclovir. The primary oral infection may range from asymptomatic to very painful, leading to poor oral intake and dehydration.
Valacyclovir may work especially well for preventing herpes transmission among heterosexual patients when one partner has herpes simplex virus 2 (HSV-2) and the other partner does not. Until recently, the general rule was to assume that HSV-1 infections occur in the oral cavity (mouth) and are not sexually transmitted, while HSV-2 attacks the genital area and is sexually transmitted. It can also occur in adult health care workers, such as dentists, because of increased exposure to the herpes virus.
Centers for Disease Control (CDC) recommends that both virologic and serologic tests be used for diagnosing genital herpes. However, valacyclovir may not be as effective as acyclovir for patients who have very frequent recurrences of herpes (more than 10 outbreaks per year). Usatine, MDFigure 3.(A) Ulcers that form after the vesicles break, as shown in an adult women with herpes labialis.
In addition, because herpes simplex virus 1 can be passed in saliva, people should also avoid sharing toothbrushes or eating utensils with an infected person.Transmission of Genital Herpes.
Patients diagnosed with genital herpes should also be tested for other sexually transmitted diseases.According to the CDC, up to 50% of first-episode cases of genital herpes are now caused by herpes simplex virus 1 (HSV-1).
Genital herpes is most often transmitted through sexual activity, and people with multiple sexual partners are at high risk. However, recurrences of genital herpes, and viral shedding without overt symptoms, are much less frequent with HSV-1 infection than herpes simplex virus 2 (HSV-2). Centers for Disease Control, famciclovir is somewhat less effective than acyclovir or valacyclovir for suppressing viral shedding.Because the frequency of herpes recurrences often diminishes over time, patients should discuss annually with their doctors whether they should stay with drug therapy or discontinue it. The virus, however, can also enter through the anus, skin, and other areas.People with active symptoms of genital herpes are at very high risk for transmitting the infection. Fortunately, rapid diagnostic tests and treatment with acyclovir have significantly improved survival rates and reduced complication rates. It is important for doctors to determine whether the genital herpes infection is caused by HSV-1 or HSV-2, as the type of herpes infection influences prognosis and treatment recommendations.Virologic TestsViral culture tests are made by taking a fluid sample, or culture, from the lesions as early as possible, ideally within the first 3 days of the outbreak.
The virus does not multiply, but both the host cells and the virus survive.At unpredictable times, the virus begins multiplying again.
Unfortunately, evidence suggests about a third of all herpes simplex virus 2 (HSV-2) infections occur when the virus is shedding but producing no symptoms. Most people either have no symptoms or don't recognize them when they appear.In the past, genital herpes was mostly caused by HSV-2, but HSV-1 genital infection is increasing. This may be due to the increase in oral sex activity among young adults.SymptomsSymptoms vary depending on whether the outbreak is initial or recurrent. Herpes meningitis, an inflammation of the membranes that line the brain and spinal cord, occurs in up to 10% of cases of primary genital HSV-2. Viral cultures are very accurate if lesions are still in the clear blister stage, but they do not work as well for older ulcerated sores, recurrent lesions, or latency.
The use of condoms during asymptomatic periods is still essential, even when patients are taking these medications.Risk for Resistant Viruses.
At these stages the virus may not be active enough to reproduce sufficiently to produce a visible culture.Polymerase chain reaction (PCR) tests are much more accurate than viral cultures, and the CDC recommends this test for detecting herpes in spinal fluid when diagnosing herpes encephalitis (see below). This close-up view of early herpes outbreak shows small, grouped blisters (vesicles) and lots of inflammation (erythema). PCR can make many copies of the virus’ DNA so that even small amounts of DNA in the sample can be detected.
In fact, studies indicate that 10 - 25% of people infected with HSV-2 are unaware that they have genital herpes. Fortunately, after lasting for up to a week, herpes meningitis usually resolves without complications, although recurrences have been reported. PCR is much more expensive than viral cultures and is not FDA-approved for testing genital specimens.
However, patients who do not respond to standard regimens should be monitored for emergence of drug resistance.Treatment for Oral HerpesOral TreatmentsAcyclovir (Zovirax, generic), valacyclovir (Valtrex), and famciclovir (Famvir) -- the anti-viral pills used to treat genital herpes -- can also treat the cold sores associated with oral herpes. Even if infected people have mild or no symptoms, they can still transmit the herpes virus.Symptoms of Genital HerpesPrimary Genital Herpes Outbreak. However, because PCR is highly accurate, many labs have used it for herpes testing.An older type of virologic testing, the Tzanck smear test, uses scrapings from herpes lesions. In addition, acyclovir is available in topical form, as is penciclovir (a related drug).Topical TreatmentsThese ointments or creams can help shorten healing time and duration of symptoms.
For patients with symptoms, the first outbreak usually occurs in or around the genital area 1 - 2 weeks after sexual exposure to the virus.


The scrapings are stained and examined under a microscope for the presence of giant cells with many nuclei or distinctive particles that carry the virus (called inclusion bodies).
However, none are truly effective in eliminating outbreaks.Penciclovir (Denavir) heals herpes simplex virus 1 (HSV-1) sores on average about half a day faster than without treatment, stops viral shedding, and reduces the duration of pain. The Tzanck test is not reliable for providing a conclusive diagnosis of herpes infection and is not recommended by the CDC.Serologic TestsSerologic (blood) tests can identify antibodies that are specific for either herpes virus simplex 1 (HSV-1) or herpes virus simplex 2 (HSV-2). When the herpes virus infects someone, their body’s immune system produces specific antibodies to fight off the infection.
The lesions may sometimes itch, but itching decreases as they heal.About 40% of men and 70% of women develop other symptoms during initial outbreaks of genital herpes, such as flu-like discomfort, headache, muscle aches, fever, and swollen glands.
If a blood test detects antibodies to herpes, it’s evidence that you have been infected with the virus, even if the virus is in a non-active (dormant) state.
They include Anbesol gel, Blistex lip ointment, Camphophenique, Herpecin-L, Viractin, and Zilactin.
Herpes gladiatorum is often seen in athletes who wrestle, which may put them in close physical contact with an infected person. The CDC recommends only type-specific glycoprotein (gG) tests for herpes diagnosis.Serologic tests are most accurate when performed 12 - 16 weeks after exposure to the virus. The virus sheds for a much shorter period of time (about 3 days) compared to in an initial outbreak of 3 weeks. Herpetic sycosis is a follicular infection with HSV that causes vesiculopapular lesions in the beard area.
There are some differences in frequency of recurrence depending on whether HSV-2 or HSV-1 causes genital herpes. HSV-2 genital infection is more likely to cause recurrences than HSV-1.Symptoms of Oral HerpesOral herpes (herpes labialis) is most often caused by herpes simplex virus 1 (HSV-1) but can also be caused by herpes simplex virus 2 (HSV-2). A herpes infection may occur on the cheeks or in the nose, but facial herpes is very uncommon.Primary Oral Herpes Infection. Always check with your doctor before using any herbal remedies or dietary supplements.Many herbal and dietary supplement products claim to help fight herpes infection by boosting the immune system.
In adolescents, the primary infection is more apt to appear in the upper part of the throat and cause soreness.Recurrent Oral Herpes Infection.
It is costly and time consuming, however, and is not as widely available as the other tests.False-negative (testing negative when herpes infection is actually present) results can occur if tests are done in the early stages of infection.
False-positive results (testing positive when herpes infection is not actually present) can also occur, although less often than false-negative. The polymerase chain reaction (PCR) assay of cerebrospinal fluid detects tiny amounts of DNA from the virus, and then replicates them millions of times until the virus is detectable.
PCR identifies HSV in cerebrospinal fluid and gives a rapid diagnosis of herpes encephalitis in most cases, eliminating the need for biopsies.
The CDC recommends PCR for diagnosing herpes central nervous system infections.Imaging Tests.
Seroprevalence of herpes simplex virus type 2 among persons aged 14 - 49 years -- United States, 2005-2008. Brain biopsy is the most reliable method of diagnosing herpes encephalitis, but it is also the most invasive and is generally performed only if the diagnosis is uncertain.
Usatine, MDFigure 9.Vesicles on a red base of the wrist in a woman with herpes gestationis after the loss of a pregnancy.
With the increased use of PCR, biopsies for herpes are now only rarely performed.Similar ConditionsCanker Sores (Aphthous Ulcers). Simple canker sores (known medically as aphthous ulcers) are often confused with the cold sores of herpes simplex virus 1 (HSV-1).
Oral herpes can be triggered within about 3 days of intense dental work, particularly root canal or tooth extraction.Timing of Recurrences. Human herpes simplex virus infections: epidemiology, pathogenesis, symptomatology, diagnosis, and management. However, the immune system cannot kill the virus completely.Risk FactorsRisk for Oral HerpesOral herpes is usually caused by HSV-1. While HSV-2 remains the main cause of genital herpes, in recent years HSV-1 has significantly increased as a cause, most likely because of oral-genital sex. Except for people in monogamous relationships with uninfected partners, everyone who is sexually active is at risk for genital herpes.Risk factors for genital herpes include a history of a prior sexually transmitted disease, early age for first sexual intercourse, a high number of sexual partners, and loq socioeconomic status. Women are more susceptible to HSV-2 infection because herpes is more easily transmitted from men to women than from women to men. Third trimester antiviral prophylaxis for preventing maternal genital herpes simplex virus (HSV) recurrences and neonatal infection.
A meta-analysis to assess the efficacy of oral antiviral treatment to prevent genital herpes outbreaks. This group is at higher than average risk for herpetic whitlow, herpes that occurs in the fingers.Wrestlers, rugby players, and other athletes who participate in direct contact sports without protective clothing. These individuals are at risk for herpes gladiatorum, an unusual form of HSV-1 that is spread by skin contact with exposed herpes sores and usually affects the head or eyes.Preventing TransmissionInfected people should take steps to avoid transmitting genital herpes to others. It is almost impossible to defend against the transmission of oral herpes since it can be transmitted by very casual contact.Genital herpes is contagious from the first signs of tingling and burning (prodrome) until the time that sores have completely healed.
Natural condoms made from animal skin do NOT protect against HSV infection because herpes viruses can pass through them.Use a water-based lubricant. Genital shedding of herpes simplex virus among symptomatic and asymptomatic persons with HSV-2 infection. However, it is best not to use condoms pre-lubricated with spermicides.Do not use spermicides for protection against herpes. If you do, be sure to immediately wash your hands with hot water and soap.The herpes virus does not live very long outside the body. While the chances of transmitting or contracting herpes from a toilet seat or towel are extremely low, it is advisable to wipe off toilet seats and not to share damp towels.Recent studies have suggested that male circumcision may help reduce the risk of HSV-2, as well as human papillomavirus (HPV) and HIV infections. Except in very rare instances and special circumstances, HSV is not life threatening.Herpes and PregnancyPregnant women who have genital herpes due to either herpes simplex virus 2 (HSV-2) or herpes simplex virus 1 (HSV-1) have an increased risk for miscarriage, premature labor, inhibited fetal growth, or transmission of the herpes infection to the infant either in the uterus or at the time of delivery.
Herpes in newborn babies (herpes neonatalis) can be a very serious condition.Fortunately, neonatal herpes is rare. Although about 25 - 30% of pregnant women have genital herpes, less than 0.1% of babies are born with neonatal herpes.
This increased risk is present if the woman is having or has recently had an active herpes outbreak in the genital area.Very rarely, the virus is transmitted across the placenta, a form of the infection known as congenital herpes. Also rarely, newborns may contract herpes during the first weeks of life from being kissed by someone with a herpes cold sore.
Infants may get congenital herpes from a mother with an active herpes infection at the time of birth. Aggressive treatment with antiviral medication is required, but it may not help systemic herpes.



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