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admin | Category: What Are Symptoms For Herpes | 13.02.2014
The results show that 163 patients with stage-three and early stage-four melanoma who were treated with T-VEC lived for an average of 41 months. T-VEC is a modified form of herpes virus which multiplies inside cancer cells and bursts them from within.
A new treatment may be in the cards for patients with skin cancer - in the form of a genetically engineered herpes virus.
In a phase 3 trial, researchers found the treatment, called Talimogene Laherparepvec (T-VEC), slowed disease progression in patients with melanoma - the deadliest form of skin cancer.
According to the research team - led by Kevin Harrington, professor of biological cancer therapies at ICR and honorary consultant at the Royal Marsden - their study represents the first phase 3 trial to demonstrate the benefits of viral immunotherapy for cancer patients.
Developed by biopharmaceutical company Amgen - who funded the study - T-VEC is a genetically modified form of the herpes simplex virus type 1 (HSV-1), which can multiply inside cancer cells and kill them. The virus has been engineered to produce a molecule called GM-CSF, which works by coaxing the immune system to destroy cancer cells. The treatment response of some patients given T-VEC even lasted longer than 3 years - a time period oncologists frequently use as a benchmark for a cure when it comes to cancer immunotherapy, according to the team. Patients with stage III and early stage IV melanoma who were given the control immunotherapy survived for an average of 21.5 months, the results show, while those who received T-VEC lived for an average of 41 months. The researchers found patients with stage IIIB, IIIC and IVM1a melanoma - less advanced forms of the cancer - showed the strongest responses to T-VEC, as did those who had not undergone any other treatment for the disease. In this case we are harnessing the ability of an engineered virus to kill cancer cells and stimulate an immune response.
The Utah Cancer Institute possibly found a cure for melanoma, which is one of the most deadliest types of cancer out there, and also the most common.
This is all part of the reason why the researchers at the Utah Cancer Institute are so concerned with finding a cure or treatment option for skin cancer, specifically melanoma.


The study shows that over 60 percent of patients have seen huge results, with 25 percent seeing a complete cure of the melanoma. Researchers warn people about the warning signs of melanoma as well as risk factors, because prevention and early detection is key in fighting off this severe disease. But treatment isn't a one-size-fits-all approach.Cancer researchers have long explored the potential of modified viruses, such as pox, parvo and coxsackie, in treating the disease. This year, around 73,870 new cases of melanoma will be diagnosed, and almost 10,000 people will die from the disease. Harrington and colleagues randomized 436 patients with advanced, inoperable malignant melanoma to receive either an injection with T-VEC or a control immunotherapy.
The virus has also been modified to remove two genes - ICP34.5 and ICP47 - preventing it from multiplying in healthy cells. This indicates that T-VEC could be used as a primary treatment for inoperable metastatic melanoma, notes the team. Louis, MO, which revealed how personalized vaccines can trigger a strong immune response against tumor mutations in patients with melanoma.
When it comes to the most deadly or progressive types of skin cancer, melanoma is the worst, and it forms within the skin cells that produce melanin. The researchers have actually mutated the herpes virus, injected it into the tumors of the melanoma, and then the virus begins attacking the cancer cells. Often times, the melanoma would not be attacked by the immune system, since the cancer cells would hide, and the body wouldn’t know it was a bad cell.
If you have fair skin, history of melanoma in your family, a history of sunburn, weak immune system, and many unusual moles or just a lot of moles, you have a higher risk of developing melanoma. It is one of a new wave of virus-based drugs to show benefits in cancer trials, and is now the first to do so in a major randomized, controlled phase III trial.


Now headlines are suggesting that this potential may have been realized.Initial findings published in the Journal of Oncology on May 26 show that a genetically engineered herpes virus, known as T-VEC, could be especially beneficial for patients with melanoma, the deadliest form of skin cancer.
In order to get the herpes virus to work this way, the researchers have to alter the virus, so that it will only kill off cancer cells, and not kill off the normal healthy cells. Now, the herpes virus is being used to spark the immune system response through memory, and that has completely cured 25 percent of patients already.
As of right now, manipulating the herpes virus to treat and cure melanoma is looking promising, but researchers warn this is still in the early stages of development. You can avoid getting melanoma by wearing protective clothing when outside, wearing sunscreen, and avoiding the midday sunlight. Over 76 percent of cancer deaths are from melanoma, and in 2015, it is estimated the 73,870 new cases will be diagnosed just in the United States alone. This treatment allows the patients to avoid chemotherapy and radiation, which keeps the healthy cells healthy, while allowing the immune system the chance to fight the melanoma at the core site of the disease. The treatment that the Utah Cancer Institute is trying with the herpes virus is known as cancer immunotherapy, which is done by just using the immune system of the person to help fight off the cancer cells. A modified version of the Herpes Simplex 1 virus (known for causing cold sores and some cases of genital herpes) called T-Vec has successfully been used to treat melanoma in a phase III clinical trial.



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