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admin | Category: Can Olive Leaf Cure Herpes | 26.10.2015
A cross-sectional study of herpes simplex virus types 1 and 2 in college students: occurrence and determinants of infection.
Longitudinal evaluation of herpes simplex virus DNA load during episodes of herpes labialis. The natural history of recurrent herpes simplex labialis: implications for antiviral therapy. Comparison of Chemicon SimulFluor direct fluorescent antibody staining with cell culture and shell vial direct immunoperoxidase staining for detection of herpes simplex virus and with cytospin direct immunofluorescence staining for detection of varicellazoster virus. Acute herpetic gingivostomatitis in adults: a review of 13 cases, including diagnosis and management.
Treatment of herpes simplex gingivostomatitis with aciclovir in children: a randomised double blind placebo controlled study.
Interventions for the prevention and treatment of herpes simplex virus in patients being treated for cancer. Single-dose, patient-initiated famciclovir: a randomized, double-blind, placebo-controlled trial for episodic treatment of herpes labialis. Valacyclovir and topical clobetasol gel for the episodic treatment of herpes labialis: a patient-initiated, double-blind, placebo-controlled pilot trial.
Clinical efficacy of topical docosanol 10% cream for herpes simplex labialis: a multi-center, randomized, placebo-controlled trial. Acyclovir cream for treatment of herpes simplex labialis: results of two randomized, double-blind, vehicle-controlled, multicenter clinical trials. Oral herpes is easy to diagnose when a patient has visible sores or ulcers, but early stages of herpes on the face and mouth as well as on the genitals are harder to diagnose. Herpes should be distinguished from herpes zoster, chicken pox, impetigo, and drug eruptions. Herpetic sores are classified as heat sores in TCM because the lesions are red and follow febrile disease conditions.
Although most Genital Herpes infections are caused by HSV-2 and most Oral Herpes infections are caused by HSV-1, we now know that either virus, Type 1 or Type 2 can cause blisters or sores known as Genital Herpes.
A condom can prevent herpes transmission during vaginal or anal sex, but oral contact with genitals or open sores anywhere can spread the disease.
Genital herpes is an STD that is also passed on through skin contact, usually during sexual intercourse. The virus travels from the skin during contact to the sensory dorsal root ganglion, where latency is established. The mouth lesions (herpetic gingivostomatitis) consist of painful vesicles on a red, swollen base that occur on the lips, gingiva, oral palate, or tongue.


However, if the pattern of the lesions is not specific to HSV, its diagnosis can be made by viral culture, PCR, serology, direct fluorescent antibody testing, or Tzanck test.
During active disease phases there are blisters on the skin which contain the infectious virus.
The diagnosis of an infection with herpes simplex virus type 1 is usually made by the appearance of the lesions (grouped vesicles or ulcers on an erythematous base) and patient history. Herpes may affect the mouth (oral herpes or HSV Type 1) or the genitals (genital herpes or HSV Type 2). No treatment will permanently eradicate oral herpes simplex infections, but acyclovir may shorten the healing time for individual episodes. However, if uncertain, the diagnosis of herpes labialis can be made by viral culture, polymerase chain reaction, serology, direct fluorescent antibody testing, or Tzanck test. Herpes simplex type 1, which is transmitted through oral secretions or sores on the skin, can be spread through kissing or sharing objects such as toothbrushes or eating utensils.
In the case of oral HSV-1, many of the approximately 100 million Americans who are infected acquired the virus when they were children. Other nonoral herpes simplex virus type 1 infections include herpetic keratitis, herpetic whitlow, herpes gladiatorum, and herpetic sycosis of the beard area. The swab should be sent in special viral transport media directly to the laboratory (or placed on ice if transport will be delayed). Viruses are transported along the sensory nerves to the nerve cell bodies where they go dormant and reside as long as the host is alive. Symptoms of herpes simplex virus typically appear as a blister or as multiple blisters on or around affected areas – usually the mouth, genitals, or rectum. The differential diagnosis of nongenital herpes simplex virus infection includes aphthous ulcers, acute paronychia, varicellazoster virus infection, herpangina, herpes gestationis (pemphigoid gestationis), pemphigus vulgaris, and Behcet syndrome. When genital herpes symptoms do appear, they are usually worse during the first outbreak than during recurring attacks. For herpes, it’s preferable to have this test done within 48 hours after symptoms first show up for a more accurate result. Oral acyclovir suspension is an effective treatment for children with primary herpetic gingivostomatitis. Usatine, MDFigure 2.Primary herpetic gingivostomatitis caused by herpes simplex virus type 1 shown in (A) a four-year-old girl with lower lip ulcers and crusting on the upper lip, and (B) a two-year-old girl with ulcers on the lower lip and tongue.
When it becomes active the virus multiplies, travels along the axon of the neuron to the nerve terminals in the skin and releases the virus particles. However, according to the American Sexual Health Association’s (ASHA) Herpes Resource Center, a positive HSV-2 result most likely points to genital rather than oral herpes because most cases of genital herpes are caused by HSV-2.


Oral acyclovir, valacyclovir, and famciclovir are effective in treating acute recurrence of herpes labialis (cold sores). A Tzanck test is difficult to perform correctly without specific training in its use, but it may be done in the office setting by scraping the floor of the herpetic vesicle, staining the specimen, and looking for multinucleated giant cells. Recurrences of herpes labialis may be diminished with daily oral acyclovir or valacyclovir. Usatine, MDIn recurrent herpes labialis, symptoms of tingling, pain, paresthesias, itching, and burning precede the lesions in 60 percent of persons.5 The lesions then appear as clusters of vesicles on the lip or vermilion border (Figure 1). Also, see eMedicineHealth’s patient education articles Oral Herpes, Canker Sores, Measles, Mumps, Chemical Burns, and Allergic Reaction. Topical acyclovir, penciclovir, and docosanol are optional treatments for recurrent herpes labialis, but they are less effective than oral treatment. Nongenital herpes simplex virus type 1 (HSV-1) is a common infection that most often involves the oral mucosa or lips (herpes labialis). Symptoms of herpes simplex virus infection include watery blisters in the skin or mucous membranes of the mouth, lips or genitals. It may also be sexually transmitted, including contact with saliva, such as kissing and mouth-to-genital contact (oral sex).
Usatine, MDFigure 3.(A) Ulcers that form after the vesicles break, as shown in an adult women with herpes labialis.
Oral herpes is an infection caused by the herpes simplex virus, characterized by an eruption of small and usually painful blisters on the skin of the lips, mouth, gums or the skin around the mouth. Oral herpes symptoms include cold sores or fever blisters which show up on the lips or around the mouth. Herpes can be spread both by direct sexual contact (including oral) and through saliva (kissing) with an infected individual. Herpes gladiatorum is often seen in athletes who wrestle, which may put them in close physical contact with an infected person. Herpetic sycosis is a follicular infection with HSV that causes vesiculopapular lesions in the beard area. Usatine, MDFigure 9.Vesicles on a red base of the wrist in a woman with herpes gestationis after the loss of a pregnancy.



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