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admin | Category: Oral Herpes Treatment At Home | 05.08.2014
Genocea Biosciences – Our lead candidate in HSV-2 is GEN-003, a first-in-class, protein subunit, therapeutic T cell vaccine designed to reduce the duration and severity of clinical symptoms associated with moderate-to-severe HSV-2, and to control transmission of the infection. This study is a double-blind, placebo-controlled dose escalation clinical trial enrolling approximately 150 volunteers with moderate-to-severe HSV-2 infection who are otherwise healthy.
Unlike prior investigational vaccines for HSV-2, GEN-003 is designed as a protein subunit vaccine to induce balanced B and T cell immune responses, which may be critical for addressing infections not sufficiently controlled by the B cell, or antibody, arm of the immune system alone.
There is currently no preventive vaccine or cure for HSV-2, and therapeutic options are limited to daily antiviral medications or suppressive therapy.
After being hurt, I thought I would only be able to be with someone who had herpes as well.
During the study minor adverse events (AEs) were reported but considered unrelated to the vaccine. TUESDAY, March 10, 2015 (HealthDay News)—There's a glimmer of hope in the fight against genital herpes: A new study in mice hints at the success of a vaccine against the virus. Researchers at Albert Einstein College of Medicine in New York City report that the vaccine was safe and effective in protecting mice against herpes simplex virus type 2 (HSV-2), the virus that causes genital herpes. The vaccine also shows indications of being effective against oral herpes, which causes cold sores, according to the authors of the study published March 10 in the online journal eLife. While the findings are promising, experts note that results from animal studies often do not pan out in human trials.
According to the researchers, genital herpes is one of the most common sexually transmitted diseases, affecting about 500 million people worldwide.

Admedus Limited (ASX:AHZ) has received a resounding vote of confidence into the safety profile of its Herpes Simplex 2 (HSV-2) vaccine Phase II study.
More than 80% of the required study participants have either begun screening or received their initial dosing regimen. It provides routine checks as per study protocol to ensure patient safety standards are met during each stage of the trial. Admedus’ HSV-2 therapeutic vaccine is based on a platform technology initially developed by Professor Frazer. GEN-003 is an investigational vaccine designed to stimulate T cell and B cell immune responses to potentially reduce the frequency and severity of clinical outbreaks associated with moderate-to-severe Herpes Simplex Virus type 2 (HSV-2) infection.
The study will seek to evaluate the safety and tolerability of GEN-003 and its ability to stimulate the immune system, as well as determine the impact of the vaccine upon viral shedding, which is considered to be a marker of disease recurrence and transmission. The vaccine is comprised of two proteins, ICP4 and gD2, as well as Matrix M™, a proprietary adjuvant from Isconova AB.
If approved, GEN-003 would be the first therapeutic vaccine for patients with HSV-2 infection. A total of 40 otherwise healthy HSV-2 positive volunteers are needed for the trial, although the study does allow for over enrolments.Admedus VaccinesAdmedus Vaccines was founded in 2000 by the Professor Frazer as a private unlisted company, to develop and commercialise patented technology for improving immune responses to DNA vaccines licensed by UniQuest Pty Ltd and developed at the University of Queensland.
The study will also assess the vaccine’s impact on viral shedding, the process by which the virus can spread between people. If someone doesn’t like you because you have Herpes then they are not the right person for you because a real person who loves you will accept you in sickness AND in health.

These results showed a clear dose response over the 3 injections and illustrated that patients confirmed to be sero-negative for HSV-2 had generated an immune response to the vaccine.The DTH response is a cell mediated response.
The cell mediated immunity response shown in this study, where the study subjects had no previous HSV-2 infection, demonstrates utility of this vaccine.
The cascade of events initiated by the T cells leads to hardening (induration) and redness (erythema) at the injection site, which was clearly evident in these study subjects.The safety profile and the detected immune response provides the basis for the company to select appropriate vaccine doses to progress the therapeutic vaccine into a Phase II study in individuals suffering recurrent genital lesions. Over the course of the study, the 3 intradermal injections of the vaccine were found to be safe and well tolerated with some local redness being observed post injection which dissipated over time.
The second component of the technology, also patent protected, is to use a mixture of DNAs encoding ubiquitinated and non ubiquitinated proteins.HSV-2HSV-2 is the major causative agent of genital herpes, which often results in recurrent painful sores in the genital area and for which there is no cure.
Herpes may (hopefully not soon) last a life time but a child is for 18 years but 100x more expensive. I would pray and hope that a cure to get rid of herpes for good would come sooner rather then later.

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Comments »

  1. | Diams — 05.08.2014 at 16:57:39 Not plenty of evidence, however genital herpes.
  2. | AnTiSpAm — 05.08.2014 at 22:29:14 Private elements) during oral sex the gene is transported into.
  3. | Brad_Pitt — 05.08.2014 at 14:29:23 That researchers look at potentialities for an HIV-1 vaccine virus from.