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admin | Category: Oral Herpes Treatment At Home | 30.08.2014
Creating a successful vaccine against two members of the family, the sexually transmitted herpes simplex virus 1 (HSV-1) and 2 (HSV-2), has proven to be challenging. Now Knipe and his colleagues have shown that compounds that block this crucial step in HIV infection also prevent genital herpes and other herpes virus infections from taking hold. The scientists tested the HIV integrase-inhibiting drug against herpes viruses, using it against HSV-1 and HSV-2 as well as the related cytomegalovirus and Kaposi's sarcoma herpes virus. An existing drug, acyclovir, effectively calms HSV-1 and HSV-2 outbreaks, but there are fewer choices for treating the reactivation of dormant cytomegaloviruses and Kaposi's sarcoma herpes viruses in people whose immune systems are compromised.
Researchers have launched an early-stage clinical trial of an investigational vaccine designed to prevent genital herpes disease.
The faster they come up with a vaccine that works, the better it will be for the general population. On Wednesday night's Republican debate, Trump tried on the hat of doctor, saying we need to change the way we vaccinate our kids.
A biotechnology company in Australia is now recruiting participants to test a herpes vaccine aimed to both prevent and cure herpes simplex 2 infections. Coridon, a biotechnology company that started out of University of Queensland, has received approval to begin early-stage, Phase I human trials for its herpes simplex 2 (HSV-2) vaccine, which would be used as both a preventative vaccine and a therapeutic vaccine for those who already carry the virus. Herpes simplex 2, also known as genital herpes, is a viral infection that can infect skin cells of a certain area of the body, such as the mouth and genital area, resulting in periodic outbreaks. The only treatments for herpes is Valtrex, which is a pill that is not completely covered by U.S. Genital herpes affects more than one in six Americans between the ages of 14 and 49, according to the Centers for Disease Control and Prevention (CDC).
A previous vaccine tested by GlaxoSmithKline flopped in late-stage clinical trials, wasting 20 years and $100 million's worth of research money. During the study minor adverse events (AEs) were reported but considered unrelated to the vaccine.


Genocea Biosciences – Our lead candidate in HSV-2 is GEN-003, a first-in-class, protein subunit, therapeutic T cell vaccine designed to reduce the duration and severity of clinical symptoms associated with moderate-to-severe HSV-2, and to control transmission of the infection.
This study is a double-blind, placebo-controlled dose escalation clinical trial enrolling approximately 150 volunteers with moderate-to-severe HSV-2 infection who are otherwise healthy. Unlike prior investigational vaccines for HSV-2, GEN-003 is designed as a protein subunit vaccine to induce balanced B and T cell immune responses, which may be critical for addressing infections not sufficiently controlled by the B cell, or antibody, arm of the immune system alone.
There is currently no preventive vaccine or cure for HSV-2, and therapeutic options are limited to daily antiviral medications or suppressive therapy. After being hurt, I thought I would only be able to be with someone who had herpes as well. A clinical trial being conducted by a branch of the National Institutes of Health, now enrolling patients, is based on an HSV-2 vaccine developed by David Knipe, Higgins Professor of Microbiology and Molecular Genetics at Harvard Medical School. Seizing an approach used against HIV, they are studying possible treatments that could also combat herpes virus infections. Their results, published in July in the journal mBio, raise hopes for a new class of anti-herpes drugs that could potentially fend off both HIV and the herpes viruses.
We have seen very encouraging results from animal studies and we expect pivotal data showing that our vaccine, which incorporates our patented optimisation technology, to produce similar immune responses in the clinic," said Professor Frazer who founded Coridon in 2000 and is leading the study.
Phase I trials usually use doses of drugs or vaccines that are meant to test the safe dosing range and may confer protection to those who participate in the trial. GEN-003 is an investigational vaccine designed to stimulate T cell and B cell immune responses to potentially reduce the frequency and severity of clinical outbreaks associated with moderate-to-severe Herpes Simplex Virus type 2 (HSV-2) infection. The study will seek to evaluate the safety and tolerability of GEN-003 and its ability to stimulate the immune system, as well as determine the impact of the vaccine upon viral shedding, which is considered to be a marker of disease recurrence and transmission. The vaccine is comprised of two proteins, ICP4 and gD2, as well as Matrix M™, a proprietary adjuvant from Isconova AB.
If approved, GEN-003 would be the first therapeutic vaccine for patients with HSV-2 infection.


They screened similar compounds from an NIH library of HIV integrase inhibitors, coming up with some candidates that took much less drug to work better in herpes viruses. These results showed a clear dose response over the 3 injections and illustrated that patients confirmed to be sero-negative for HSV-2 had generated an immune response to the vaccine.The DTH response is a cell mediated response. The study will also assess the vaccine’s impact on viral shedding, the process by which the virus can spread between people.
If someone doesn’t like you because you have Herpes then they are not the right person for you because a real person who loves you will accept you in sickness AND in health.
The cell mediated immunity response shown in this study, where the study subjects had no previous HSV-2 infection, demonstrates utility of this vaccine. The cascade of events initiated by the T cells leads to hardening (induration) and redness (erythema) at the injection site, which was clearly evident in these study subjects.The safety profile and the detected immune response provides the basis for the company to select appropriate vaccine doses to progress the therapeutic vaccine into a Phase II study in individuals suffering recurrent genital lesions. Over the course of the study, the 3 intradermal injections of the vaccine were found to be safe and well tolerated with some local redness being observed post injection which dissipated over time. Herpes may (hopefully not soon) last a life time but a child is for 18 years but 100x more expensive. I would pray and hope that a cure to get rid of herpes for good would come sooner rather then later. I dont want to feel scared to date someone new and I dont want to stay with someone simply because they accept me as well as also share my condition.



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Comments »

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