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admin | Category: Oral Herpes Treatment At Home | 11.07.2014
Genocea Biosciences – Our lead candidate in HSV-2 is GEN-003, a first-in-class, protein subunit, therapeutic T cell vaccine designed to reduce the duration and severity of clinical symptoms associated with moderate-to-severe HSV-2, and to control transmission of the infection. This study is a double-blind, placebo-controlled dose escalation clinical trial enrolling approximately 150 volunteers with moderate-to-severe HSV-2 infection who are otherwise healthy. There is currently no preventive vaccine or cure for HSV-2, and therapeutic options are limited to daily antiviral medications or suppressive therapy. I would definantly feel relieved and feel like I can life normally again if a cure is on its way. After being hurt, I thought I would only be able to be with someone who had herpes as well.
A biotechnology company in Australia is now recruiting participants to test a herpes vaccine aimed to both prevent and cure herpes simplex 2 infections.
Coridon, a biotechnology company that started out of University of Queensland, has received approval to begin early-stage, Phase I human trials for its herpes simplex 2 (HSV-2) vaccine, which would be used as both a preventative vaccine and a therapeutic vaccine for those who already carry the virus. Herpes simplex 2, also known as genital herpes, is a viral infection that can infect skin cells of a certain area of the body, such as the mouth and genital area, resulting in periodic outbreaks. The only treatments for herpes is Valtrex, which is a pill that is not completely covered by U.S. Genital herpes affects more than one in six Americans between the ages of 14 and 49, according to the Centers for Disease Control and Prevention (CDC). A previous vaccine tested by GlaxoSmithKline flopped in late-stage clinical trials, wasting 20 years and $100 million's worth of research money. We have recently extended our efforts to cure HSV infections by developing DNA editing enzymes as potential HSV treatments. Vical is undergoing Phase I clinical trials and is expected to report baseline data by the middle of 2015. Ultimately larger clinical trials will be required to determine the clinical utility and safety.
Coridon’s herpes vaccine program has shown very positive animal data in clearing the virus, with longer term follow up data showing continued persistence of the immune response. Results of the trial are due approximately in 1QCY14.Based on success to date, an effective vaccine for herpes looks to be within grasp, providing a grand prize for Allied Healthcare in potential revenue. GEN-003 is an investigational vaccine designed to stimulate T cell and B cell immune responses to potentially reduce the frequency and severity of clinical outbreaks associated with moderate-to-severe Herpes Simplex Virus type 2 (HSV-2) infection.


Yes it would be great if a cure was found but until then you just have to accept it and deal with it. We have seen very encouraging results from animal studies and we expect pivotal data showing that our vaccine, which incorporates our patented optimisation technology, to produce similar immune responses in the clinic," said Professor Frazer who founded Coridon in 2000 and is leading the study. After that, assuming things go well, this drug might proceed to clinical trials in HSV-1 infected individuals.
PaxVax, a specialty vaccine company has started a cooperation with the Spector Lab at the UC San Diego Department of Cellular and Molecular Medicine, regarding the development of a genital herpes viral vector vaccine, which is currently in the preclinical stage.
If someone doesn’t like you because you have Herpes then they are not the right person for you because a real person who loves you will accept you in sickness AND in health. A cure would be worth anything to me or a time machine so I could not get involved with him in the first place. A clinical trial being conducted by a branch of the National Institutes of Health, now enrolling patients, is based on an HSV-2 vaccine developed by David Knipe, Higgins Professor of Microbiology and Molecular Genetics at Harvard Medical School.
A cure would be nice for my comfort so I wouldn’t have to deal with outbreaks but its not necessary. Researchers have launched an early-stage clinical trial of an investigational vaccine designed to prevent genital herpes disease. Although more clinical trials will be needed, the drug holds out hope for the first new treatment of herpes in three decades.
Seizing an approach used against HIV, they are studying possible treatments that could also combat herpes virus infections.
On top of that, Australian biotech Admedus just announced positive early clinical results for its own genital herpes vaccine. Genital herpes is one of the most common sexually transmitted infections in the United States. Study of the Safety of a Particular Herpes Vaccine in Adults With or Without Herpes Infection.
Herpes may (hopefully not soon) last a life time but a child is for 18 years but 100x more expensive.
Participation or planned participation in another clinical trial investigating a vaccine, drug, medical device, or medical procedure in the 4 weeks preceding the first trial vaccination or during the study period up to 6 months after the last dose of vaccine or placebo. We believe that given the high infection rate and lack of any cure for HSV-2, the early successes of the company’s vaccine has the potential to open up a massive market that has not being tapped.


The GEN-003 herpes vaccine candidate is designed to manipulate the immune responses of T cells, among other therapeutic effects. If a cure is found there will be more of us all over the world who reap the benefits than any of us even no. There is no cure for herpes, but medication is available to reduce symptoms and make it less likely that you will spread herpes to a sex partner. Anna Wald, University of Washington professor of medicine and laboratory medicine in the School of Medicine and professor of epidemiology in the School of Public Health, is among those leading clinical studies of GEN-003.
Several clinical trials have tested vaccines against genital herpes infection, but there is currently no commercially available vaccine that is protective against genital herpes infection. I would pray and hope that a cure to get rid of herpes for good would come sooner rather then later. Research and clinical trials are going on to develop a vaccine or at least try to lessen the symptoms. A promising new clinical trial for a HSV2 vaccine just opened up for human research testing and is looking for volunteers. While this vaccine would not cure those of HSV-2, it could ultimately help stop the spread of this very prevalent STI. No one has made an effective vaccine for herpes simplex virus 2 (HSV-2) , better known as genital herpes. Cambridge, MA-based Genocea is announcing some interim data from its first human clinical trial for its experimental vaccine, GEN-003, for HSV-2 today at the Interscience Conference on Antimicrobial Agents and Chemotherapy in Denver. About 10 of the patients treated had complete remission, with no detectable cancer remaining – considered a cure if the patient is still cancer-free five years after diagnosis. Rather than the traditional clinical trial, where a drug is compared to a placebo, the control group were given a protein designed to stimulate the immune response against cancer, but without the virus component of the treatment. There could soon be a vaccine for genital herpes, the sexually transmitted infection that affects up to one in eight Australians.



Conventional medicine history
Antiviral treatment for herpes simplex


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