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admin | Category: Medicine For Herpes | 07.10.2014
Preliminary and double blind trials have found that supplementing 600 to 1,200 mg of lipoic acid per day improves insulin sensitivity and the symptoms of diabetic neuropathy. One doctor has administered a daily regimen of 500 mcg selenium, 800 IU vitamin E, 10,000 IU vitamin A, and 1,000 mg vitamin C for several years to 20 people with diabetic retinopathy. When people with type 2 diabetes were given 9 mg of biotin per day for two months, their fasting glucose levels dropped dramatically. Numerous double-blind trials have proven topically applied capsaicin creams are helpful for a range of conditions, including nerve pain in diabetes (diabetic neuropathy).ChromiumChromium has been shown to improve glucose levels and related variables in people with glucose intolerance and gestational, steroid-induced and type 2 diabetes. Chromium supplements improve glucose tolerance in people with type 2 diabetes, apparently by increasing sensitivity to insulin. Chromium improves the processing of glucose in people with prediabetic glucose intolerance and in women with diabetes associated with pregnancy. However, use of cinnamon to improve the action of insulin in people with type 2 diabetes has yet to be proven in clinical trials.Coenzyme Q10Coenzyme Q10 (CoQ10) is needed for normal blood sugar metabolism. People with type 2 diabetes have been found to have significantly lower blood levels of CoQ10 compared with healthy people. In one trial, blood sugar levels fell substantially in 31% of people with diabetes after they supplemented with 120 mg per day of CoQ7, a substance similar to CoQ10.
The importance of CoQ10 supplementation for people with diabetes remains an unresolved issue, though some doctors recommend approximately 50 mg per day as a way to protect against possible effects associated with diabetes-induced depletion. In a preliminary study of people with type 2 diabetes, supplementing with an extract from the leaves of Lagerstroemia speciosa for two weeks resulted in a fall in blood-glucose levels averaging 20 to 30%. Preliminary and double-blind trials have found that fenugreek helps improve blood sugar control in patients with type 1 and type 2 diabetes.Fish Oil Glucose tolerance improves in healthy people taking omega-3 fatty acid supplements, and some studies have found that fish oil supplementation also improves glucose tolerance, high triglycerides, and cholesterol levels in people with type 2 diabetes. And in one trial, people with diabetic neuropathy and diabetic nephropathy experienced significant improvement when given 600 mg three times per day of purified eicosapentaenoic acid (EPA)—one of the two major omega-3 fatty acids found in fish oil supplements—for 48 weeks.
However, other studies have found that type 2 diabetes worsens with fish oil supplementation. Until this issue is resolved, people with diabetes should feel free to eat fish, but they should consult a doctor before taking fish oil supplements.Fructo-Oligosaccharides (FOS)In a preliminary trial, supplementation with fructo-oligosaccharides (FOS) (8 grams per day for two weeks) significantly lowered fasting blood-sugar levels and serum total-cholesterol levels in people with type 2 diabetes.
However, in another trial, supplementing with FOS (15 grams per day) for 20 days had no effect on blood-glucose or lipid levels in people with type 2 diabetes. In addition, some double-blind trials showed that supplementing with FOS or galacto-oligosaccharides (GOS) for eight weeks had no effect on blood-sugar levels, insulin secretion, or blood lipids in healthy people. After-meal blood sugar levels are lower in people with diabetes given glucomannan in their food, and overall diabetic control is improved with glucomannan-enriched diets, according to preliminary and controlled clinical trials.


One preliminary report suggested that glucomannan may also be helpful in pregnancy-related diabetes.
For controlling blood sugar, 500 to 700 mg of glucomannan per 100 calories in the diet has been used successfully in controlled research.GymnemaThe hypoglycemic (blood sugar-lowering) action of gymnema leaves was first documented in the late 1920s.
Hibiscus is usually taken as tea, such as 1 to 2 teaspoons (3 to 6 grams) of dried flower infused in to 1 cup (250 ml) three times per day.InositolInositol is needed for normal nerve function. Diabetic neuropathy has been reported in some, but not all, trials to improve with inositol supplementation (500 mg taken twice per day).L-CarnitineL-carnitine is an amino acid needed to properly utilize fat for energy. Magnesium supplementation has improved insulin production in elderly people with type 2 diabetes. However, one double-blind trial found no effect from 500 mg magnesium per day in people with type 2 diabetes, although twice that amount led to some improvement. Elders without diabetes can also produce more insulin as a result of magnesium supplements, according to some, but not all, trials. However, in people with type 2 diabetes who nonetheless require insulin, Dutch researchers have reported no improvement in blood sugar levels from magnesium supplementation.
The American Diabetes Association acknowledges strong associations between magnesium deficiency and insulin resistance but has not said magnesium deficiency is a risk factor.
Many doctors, however, recommend that people with diabetes and normal kidney function supplement with 200 to 600 mg of magnesium per day. These results have not been reproduced in human clinical trials and as such, no clear conclusions can be made from this animal study in the treatment of diabetes.OnionTwo sets of compounds make up the majority of onion’s known active constituents—sulfur compounds, such as allyl propyl disulphide (APDS), and flavonoids, such as quercetin.
Several uncontrolled human studies and at least one double-blind clinical trial have shown that large amounts of onion can lower blood sugar levels in people with type 2 diabetes.
Onion does not reduce blood sugar levels in healthy nondiabetic people.PsylliumPsyllium supplementation has improved blood sugar levels in some people with diabetes.
The soluble fiber component of psyllium is believed to account for this effect.QuercetinDoctors have suggested that quercetin might help people with diabetes because of its ability to reduce levels of sorbitol—a sugar that accumulates in nerve cells, kidney cells, and cells within the eyes of people with type 2 diabetes—and has been linked to damage to those organs. Clinical trials have yet to explore whether quercetin actually protects people with diabetes from neuropathy, nephropathy, or retinopathy. Controlled research has demonstrated that concentrated starch blocker extracts, when given with a starchy meal, can reduce the usual rise in blood sugar levels of both healthy people and diabetics.
However, since this was a trial conducted among people in a vitamin B1–deficient developing country, these improvements might not occur in other people with diabetes. Another trial found that combining vitamin B1 (in a special fat-soluble form) and vitamin B6 plus vitamin B12 in high but variable amounts led to improvement in some aspects of diabetic neuropathy in 12 weeks.


As a result, some doctors recommend that people with diabetic neuropathy supplement with vitamin B1, though the optimal level of intake remains unknown.Vitamin B3The intake of large amounts of niacin (a form of vitamin B3), such as 2 to 3 grams per day, may impair glucose tolerance and should be used by people with type 2 diabetes only with medical supervision. Smaller amounts (500 to 750 mg per day for one month followed by 250 mg per day) may help some people with type 2 diabetes, though this research remains preliminary.Vitamin B6Many people with type 2 diabetes have low blood levels of vitamin B6. Vitamin B6 supplementation has improved glucose tolerance in women with diabetes caused by pregnancy. Vitamin B6 supplementation is also effective for glucose intolerance induced by birth control pills.
In a trial that included people with type 2 diabetes, 1,800 mg per day of a special form of vitamin B6—pyridoxine alpha-ketoglutarate—improved glucose tolerance dramatically. Standard vitamin B6 has helped in some, but not all, trials.Vitamin B12Vitamin B12 is needed for normal functioning of nerve cells.
Vitamin B12 taken orally has reduced symptoms of nerve damage caused by diabetes in 39% of people studied; when given both intravenously and orally, two-thirds of people improved. In a preliminary trial, people with nerve damage due to kidney disease or to diabetes plus kidney disease received intravenous injections of 500 mcg of methylcobalamin (the main form of vitamin B12 found in the blood) three times a day for six months in addition to kidney dialysis.
Sorbitol is a sugar that can accumulate inside the cells and damage the eyes, nerves, and kidneys of people with diabetes.
Vitamin C may improve glucose tolerance in type 2 diabetes, although not every study confirms this benefit.
Vitamin C supplementation (500 mg twice a day for one year) has significantly reduced urinary protein loss in people with diabetes. Urinary protein loss (also called proteinuria) is associated with poor prognosis in diabetes.
Many doctors suggest that people with diabetes supplement with 1 to 3 grams per day of vitamin C. Vitamin D receptors have been found in the pancreas where insulin is made, and preliminary evidence suggests that supplementation can improve some measures of blood sugar control in people with type 2 diabetes.
Vitamin E supplementation has improved glucose tolerance in people with type 2 diabetes in most, but not all, double-blind trials.
Three months or more of at least 900 IU of vitamin E per day may be required for benefits to become apparent.ZincPeople with type 2 diabetes tend to be zinc deficient, but some evidence indicates that zinc supplementation does not improve their ability to process sugar.



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