Vildagliptin in the treatment of type 2 diabetes mellitus,gl hovedgade 14 2970 h?rsholm,surgery to cure diabetes type 2 ervaringen - Downloads 2016


Vildagliptin provides unique therapeutic benefits that make it an ideal treatment for type 2 diabetes, according to Professor James E.
Foley was the guest speaker during a recent scientific forum organized by Novartis Philippines and attended by top local endocrinologists and diabetologists.
The Novartis diabetes drug vildagliptin provides unique therapeutic benefits that make it an ideal treatment for type 2 diabetes, according to an expert who is part of the Novartis team that pioneered research on this relatively new class of oral anti-diabetes drugs. Foley was the guest speaker during a scientific forum organized by Novartis Healthcare Philippines on October 11, 2011 at the Crowne Plaza Galleria Manila in Quezon City. Vildagliptin enhances bodya€™ natural blood sugar control mechanismVildagliptin belongs to a class of oral anti-diabetes drugs called DPP-4 inhibitors. GLP-1 and GIP stimulate the pancreas to produce insulin in response to increasing levels of glucose in the blood. However, GLP-1 and GIP are rapidly broken down by an enzyme in the body called dipeptidyl peptidase-4 or DPP-4. According to Foley, a large number of clinical studies and extensive clinical experience demonstrate that vildagliptin provides unique therapeutic benefits that make the drug an ideal treatment for type 2 diabetes.
Unlike other classes of oral anti-diabetes drugs, vildagliptin does not induce weight gain and hypoglycemia (low blood sugar). Novartis provides healthcare solutions that address the evolving needs of patients and societies. Background and Objective: Vildagliptin and sitagliptin are oral dipeptidyl peptidase 4 inhibitors approved in Japan for the treatment of type 2 diabetes mellitus when adequate glycaemic control is not achieved with diet, exercise or sulphonylureas. Methods: Randomized trials of vildagliptin or sitagliptin in Japanese patients were identified from the literature. Results: Two trials of vildagliptin and three trials of sitagliptin were identified for Japanese patients.
Conclusion: After adjusting for baseline differences among trials of vildagliptin and sitagliptin in Japanese patients with type 2 diabetes, vildagliptin 50 mg twice daily was associated with significantly greater HbA1c reduction than sitagliptin 50 mg or 100 mg once daily.
Vildagliptin and metformin HCL is an oral antidiabetic agent that that is of considerable use in the treatment of patients with type two diabetes. Gastrointestinal disturbances like nausea, vomiting and constipation, loss of appetite, abdominal discomfort are common. In patients with known hypersensitivity to metformin HCL or vidgliptin its is contraindicated.Renal dysfunction or preexisting renal disease or very high serum creatinine levels, CHF, diabetic ketoacidosis or hepatic impairment are some of the contraindications for the use of vildagliptin and metformin HCL tablets. It should not be given to patients suffering from type one diabetes as it cannot be given as a substitute for insulin. Foley, an expert who is part of the Novartis team that pioneered research on this relatively new class of oral anti-diabetes drugs.


Foley, PhD, Principal Medical and Scientific Expert in Diabetes, Novartis Global Medical Affairs.
Entitled a€?Incretin Update: Focus on Vildagliptina€?, the forum was attended by top local endocrinologists and diabetologists.
It works by increasing the amount of two incretin hormones found in the body, called glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP). Insulin is the main hormone responsible for controlling sugar levels in the blood by enabling cells in the body to remove sugar from the blood.
Vildagliptin works by binding to DPP-4 and preventing the enzyme from breaking down and inactivating GLP-1 and GIP. Focused solely on healthcare, Novartis offers a diversified portfolio to best meet these needs: innovative medicines, eye care, cost-saving generic pharmaceuticals, consumer health products, preventive vaccines and diagnostic tools.
The aim of this study was to compare 12-week glycaemic control with vildagliptin 50 mg twice daily versus sitagliptin 50 or 100 mg once daily in Japanese patients with type 2 diabetes.
Across all included trials, a total of 264 patients were treated with vildagliptin 50 mg twice daily, 235 were treated with sitagliptin 50 mg once daily and 145 were treated with sitagliptin 100 mg once daily. It reduces the HbA1c levels by enhancing the responsiveness of the cells present in the islets of pancreas towards glucose. It should be discontinued on a temporary basis in patients undergoing radiological studies. The monitoring of liver enzymes should be done routinely in patients having a preexisting liver disease as rare cases of hepatic dysfunction have been seen with the use of vildagliptin.
It should be taken with meals or immediately after taking food so as to reduce gastrointestinal discomfort.
Normally produced by the body in response to food intake, these hormones help control blood sugar levels in two ways. GLP-1 also reduces the production of glucagon, a hormone that normally increases glucose production by the liver.
By inhibiting DPP-4, vildagliptin increases the levels of GLP-1 and GIP in the body thereby increasing their effect on blood sugar control.
In the absence of a head-to-head randomized trial, a matching-adjusted indirect comparison was conducted by weighting individual patients from vildagliptin trials to match average baseline characteristics published for sitagliptin trials, including age, sex, body mass index, glycosylated haemoglobin (HbA1c), fasting plasma glucose (FPG) and diabetes duration.
Lactic acidosis is though a very rare but serious complication that occurs due to metformin accumulation.
After matching, HbA1c change from baseline to week 12, the primary endpoint in each trial, was compared between balanced populations treated with vildagliptin and sitagliptin.
It is also of considerable use in patients who are already being treated with the combination of the drugs metformin HCL or vidgliptin.


Due to the lack of studies on whether or not the vildagliptin and metformin HCL is excreted in milk if taken by lactating mothers it use, during the time of breastfeeding should be avoided. Headquartered in Basel, Switzerland, Novartis Group companies employ approximately 119,000 full-time-equivalent associates and operate in more than 140 countries around the world. Separate comparisons were conducted for vildagliptin 50 mg twice daily versus sitagliptin 50 mg and 100 mg once daily. Hepatobiliary Disorders are very rare side effects associated with the use of vildagliptin and metformin HCL. Dipeptidyl peptidase IV (DPP IV) inhibitors: a newly emerging drug class for the treatment of type 2 diabetes. Efficacy and safety of sitagliptin monotherapy compared with voglibose in Japanese patients with type 2 diabetes: a randomized, double-blind trial.
Dose-ranging efficacy of sitagliptin, a dipeptidyl peptidase-4 inhibitor, in Japanese patients with type 2 diabetes mellitus.
Efficacy and safety of vildagliptin and voglibose in Japanese patients with type 2 diabetes: a 12-week, randomized, double-blind, active-controlled study. Vildagliptin dose-dependently improves glycemic control in Japanese patients with type 2 diabetes mellitus. A meta-analysis of placebo-controlled clinical trials assessing the efficacy and safety of incretin-based medications in patients with type 2 diabetes. The results of direct and indirect treatment comparisons in meta-analysis of randomized controlled trials.
Comparative effectiveness without head-to-head trials: a method for matching-adjusted indirect comparisons applied to psoriasis treatment with adalimumab or etanercept.
Effects of once-daily sitagliptin on 24-h glucose control following 4 weeks of treatment in Japanese patients with type 2 diabetes mellitus. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33).
Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulin-dependent diabetes mellitus: a randomized prospective 6-year study. Clinical evidence and mechanistic basis for vildagliptina€™s action when added to metformin. Relationship of baseline HbA1c and efficacy of current glucose-lowering therapies: a meta-analysis of randomized clinical trials.



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