Type 2 diabetes treatment market share rau,diet for non-insulin-dependent diabetes mellitus,diabetes type 1 diabetic ketoacidosis - You Shoud Know

Images from the web about global markets for diabetes therapeutics and diagnostics focus on the americas, hope you like them. The global type 2 diabetes market is heating up, as obesity increases and incidents of diabetes approach epidemic proportions globally. The global market for diabetes therapeutics and diagnostics (including devices for diagnosis and monitoring, as well as therapeutic agents) is expected to climb from $110 billion in 2011 to nearly $157 billion by 2017, according to BCC Research. In the past seven years, two novel drug classes have been introduced—SGLT-2 inhibitors and GLP-1 receptor agonists. In January, Boehringer Ingelheim and Eli Lilly trumpeted topline Phase III results showing that once-daily 10 and 25 mg dosages of empagliflozin met the trial’s primary efficacy endpoint, namely significant change in HbA1c from baseline compared to placebo. Glucagon-like peptide-1 (GLP-1) receptor agonists, a new drug class introduced in 2005, also are interesting. Novo Nordisk, one of the biggest suppliers of insulin, submitted an NDA in November for Tresiba® (degludec), which offers extended dosing but increases cardiovascular risks. Already, Eli Lilly’s once-weekly GLP-1 therapeutic, dulaglutide, is garnering favorable Phase III trial results. Intarcia Therapeutics' delivery system is a matchstick-sized device consisting of a cylindrical titanium alloy reservoir. MannKind is developing an inhaled insulin that is expected to enter in the market in one to one-and-a-half years.
Diabetes therapies are well-reimbursed, but there is increasing pressure to limit costs and for new therapies to demonstrate strong clinical benefits. Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising.

Diabetes mellitus is a group of metabolic diseases characterized by chronic hyperglycemia - high blood glucose levels - that results from defects in insulin secretion, insulin action, or a combination of these.
Clipping is a handy way to collect and organize the most important slides from a presentation. Keywords: global markets, global markets definition, global markets advisory group, global markets inc, global markets analyst, global markets insight, global markets institute, global markets cnn, global markets entity identifier, global markets news, global markets for diabetes therapeutics and diagnostics focus on the americas . Although more than 40 diabetes therapeutics are approved for type 2 diabetes, there are high levels of unmet need, creating opportunities for companies in the secondary and tertiary treatment segments that address such complications as cardiovascular disease, peripheral neuropathy, and blindness. Mostly, drug development companies are focusing on neurosalvage, cardiovascular protection, and lipid management, all of which help prevent complications,” according to T.
Of novel therapeutics, the SGLT-2 inhibitors are among the most exciting because they cause patients to excrete extra glucose through the urinary system, Dr.
Trade named Ryzodeg®, it combines insulin degludec and insulin aspart to treat type 1 and type 2 diabetes. Once inserted under the skin, water from the extracellular fluid enters the device at one end, by diffusing through a semi-permeable membrane directly into a salt osmotic engine that expands to drive a piston at a controlled rate of travel.
For example, Intarcia Therapeutics is developing a GLP-1 receptor agonist implant, ITCA-650. Rapid expansion for the global diabetes market is expected during at least the next decade.
It received positive reviews from the European regulators in October 2012 and by Japanese regulators in December 2012. This forces the drug formulation to be released in a slow and consistent fashion through the exit port, or diffusion moderator, at the other end of the device.

This small osmotic pump is implanted subcutaneously and delivers therapeutics for nearly one year.
Normally, 99% of filtered glucose is reabsorbed by the kidney, thanks to sodium-glucose co-transporters (SGLT). GSK also has an IL18 monoclonal antibody in Phase I trials for type 2 diabetes and inflammatory bowel disease, and an ileal bile acid transfer inhibitor for type 2 diabetes also in Phase I trials.
Lilly also is developing a PEGylated version of its own short-acting insulin, Humalog®. In November, the company raised $210 million in financing, enabling global Phase III trials to begin the first quarter of 2013. Additionally, since 2007, the FDA mandates that diabetes therapies be evaluated for cardiovascular risk.
By administering GLP-1 therapeutics, physicians can administer less insulin for the same effect, lower the risk of hyperglycemia, and prevent the associated weight gain. Nonetheless, Decision Resources predicts that the class will experience strong growth during the next decade. In Phase II trials, early results support once-daily administration and show weight loss in patients. Patients taking MKC253 do not develop the nausea and other side effects typically associated with GLP-1 analogs.

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