Type 2 diabetes medications list generic,can i control diabetes with diet and exercise,diabetes weight loss cats knead,gert-jan otten kpn - PDF Books


A report by Pharma, a trade journal of America’s biopharmaceutical research companies, indicated in their 2014 report that there are 180 new medicines for type 1, type 2 and diabetes related complications in various stages of development.
But do we really need to spend all of this effort, time and expense bringing more diabetes medications to market? According to a recent study conducted by Tufts Center for the Study of Drug Development it costs approximately 1.2 billion dollars to bring a new medication to market.
In spite of this enormous cost, with improved medical management of diabetes and heart health, in addition to patients making healthier lifestyle choices, there has been a reduction in deaths among people with diabetes by almost 40% from 1997 to 2006 according to the Centers For Disease Control and Prevention. When I first became a CDE a little less than twenty years ago I could write the names of all of the oral diabetes medications and how they worked on one sheet of paper.
So, where do these new medications, the DPP-4 inhibitors, also known as the gliptins, and the SGLT2 inhibitors, aka the flozins, and even the GLP-1 agonists (sorry, don’t have an aka for that one yet but working on it) fit in the diabetes medication regime?
First of all if a patient is doing great right now with an A1c smack dab in the middle of the range prescribed by the doctor and experiencing minimal to no side effects, then I would say, leave well enough alone and don’t change a thing. If on the other hand, blood glucose control could stand to be improved a bit or equally important, if blood glucose control is good but the side effects of the medicine are a problem, then a look at the new medications may be a good idea.
Doctors will usually prescribe a diabetes medication based on effectiveness, tolerability and cost, but not necessarily in that order.
The medication must be effective, safe and cheap enough for the patient to be able to afford. As for the newer more costly antidiabetes medications their major advantage is less side effects making them potentially safer to use.
In fact the SGLT2’s may be responsible for weight loss due to their ability to prevent the reabsorption of glucose in the nephrons of the kidneys. The long acting exenitide (Bydureon®) a GLP-1 agonist, causes a greater A1c drop and less nausea and vomiting than the earlier short acting exenitide (Byetta®). Ultimately, the doctor now has a greater choice of medications to choose from, that is for the patient that can afford it.
Filed Under: Oral Medications About Milt BedingfieldI can help you get your type 2 diabetes under better control, many times with less or even no medicine at all.
By some estimates, diabetes cases have increased more than 700 percent in the last 50 years.
Diabetes is NOT a disease of blood sugar, but rather a disorder of insulin and leptin signaling. There is a staggering amount of misinformation on diabetes, a growing epidemic that afflicts more than 29 million people in the United States today. Most diabetics find themselves in a black hole of helplessness, clueless about how to reverse their condition. The latest diabetes statistics1 echo an increase in diabetes cases, both diagnosed and undiagnosed.
At least 29 million Americans are diagnosed with type 2 diabetes, and another 86 million are prediabetic. What’s hidden behind this medical smokescreen is that type 2 diabetes is completely preventable.
In type 1 diabetes, your own immune system ravages the insulin-producing cells of your pancreas. The far more common form of diabetes is type 2, which affects 90 to 95 percent of diabetics. The signs of diabetes may all be there, but the often-overlooked fact is that type 2 diabetes is completely preventable and nearly 100 percent curable.
Diabetes is NOT a disease of blood sugar, but rather a disorder of insulin and leptin signaling that evolves over a long period of time, moving first into a prediabetes state, and then to full-blown diabetes if left unchecked. The purpose of your pancreas is to produce the hormone insulin and secrete it into your bloodstream, thereby regulating your glucose at the levels your body needs to live. Your doctor will say that the purpose of taking these shots or pills is to lower your blood sugar. But would he or she go beyond that explanation to tell you what part leptin plays in this process, or that when your body develops a resistance to leptin, you’re on your way to diabetes, if you’re not already there?
But when Friedman also found that obese people have very high levels of leptin in their blood, he decided that something else must be going on.
Friedman and Coleman also discovered that leptin is responsible for the accuracy of insulin signaling and for your insulin resistance. Thus, the primary role of insulin is NOT to lower your blood sugar, but to store the extra energy (glycogen, a starch) for present and future consumption.
Taking insulin may even spell greater trouble for some type 2 diabetes patients, as it will worsen their leptin and insulin resistance over time.
Unfortunately, if you live in a developed country today where food is abundant and easily available, this fat switch has lost its biological advantage, and instead of helping many people live longer, it is actually working to their disadvantage and killing them prematurely.
Lawmakers whose campaigns are underwritten by agribusinesses use billions of taxpayer dollars to subsidize the commodities that are the key ingredients of unhealthy food such as corn, soybeans, and wheat.
And if the future is reflective of the past, the subsidies will only be going up, although the Congressional Budget Office (CBO) is saying they will go down in three or four years (something I wouldn’t hold my breath for). There's a common belief that healthy, fresh, whole, and organically-grown food is inherently more expensive, and thus can only be for the wealthy. Is it a coincidence that one of the top sources of calories in the United States, high-fructose corn syrup (HFCS), is made from one of the most heavily subsidized crops — corn? Recently, some companies have begun to replace HFCS with regular beet sugar in a few of their products as more and more people learn about HFCS and protest against it, but still, one of the effects of the farm bill is to create a negative feedback loop that perpetuates the highly profitable standard American diet.
These junk-food subsidies make it much cheaper to buy a burger, fries, and soda from a fast-food restaurant than it is to buy grass-fed beef and veggies. The end result is a food culture that is a primary driver of diabetes and disease, rather than a primary driver of health! The failure of conventional medicine to effectively prevent and treat diabetes is most evident in the dangerous drugs it promotes, foremost of which is Avandia.
Avandia sales, however, plummeted to 1.2 billion dollars in 2009, two years after a study published in the New England Journal of Medicine5 linked Avandia to a 43 percent increased risk of heart attack, along with a 64 percent higher risk of cardiovascular death (compared to patients treated with other methods).
You would have thought that the FDA’s next move would have been to order this drug off the market.


But in a show of either bias or callousness, a committee of independent experts recommended that Avandia remain on the market despite the risks. Avandia works by making diabetes patients more sensitive to their own insulin in order to control blood sugar levels.
In fact, most conventional type 2 diabetes treatments use drugs that either raise insulin or lower blood sugar. As I have already explained, the problem is that diabetes is NOT a disease of blood sugar. Eliminate grains and sugars and ALL processed foods, especially those made with fructose and HFCS.
Hundreds of studies are now confirming the power of vitamin D, a steroid hormone, to influence virtually every cell in your body.
Recent research shows that women can help reduce their children’s risk of type 1 diabetes by optimizing their vitamin D levels prior to and during pregnancy, as vitamin D has been shown to suppress certain cells of the immune system that may be a factor in the disease. Other studies published between 1990 and 200913 also revealed a significant link between high levels of vitamin D and a lowered risk of developing type 2 diabetes, along with cardiovascular disease and metabolic syndrome.
Ideally, you should regularly expose a large amount of your skin to healthy amounts of sunshine, preferably as close to solar noon as possible. The ONLY way to know whether the above recommendations will help you achieve your optimal D levels is to test your blood. Type 2 diabetes is a fully preventable, reversible condition that arises from faulty leptin signaling and insulin resistance.
A meta-analysis of 13 randomized controlled trials involving more than 33,000 people showed that drug treatment of type 2 diabetes is not only ineffective, it's dangerous. You will want to take special care to eliminate from your diet fructose and high-fructose corn syrup, which is far more detrimental than any other type of sugar.
This also means avoiding most processed foods of all kinds, as they are loaded with fructose.
Following my nutrition plan will help you do this without much fuss, as it walks you through the steps you need to get back on the road to optimal health.
As I explain in my new book, Effortless Healing: 9 Simple Ways to Sidestep Illness, Shed Excess Weight, and Help Your Body Fix Itself, your healing plan is in your hands.
In reality all of the unusual sounding names above are either the names of an antidiabetes drug class (SGLT2 inhibitor), brand names (Invokana®, Bydureon®and Victoza®), or the generic name of a DPP-4 inhibitor (Sitagliptin), or the generic names of an SGLT2 inhibitor (Canagliflozin and Dapagliflozin). New and improved antidiabetes medications have no doubt played a large role in this improvement.
After all, good diabetes control is not easy to achieve oftentimes and once you are in control you want to be careful not to disrupt things.
Cost and tolerance are two major factors likely to determine how compliant a person is with their medication. The sulfonylureas, biguanides and thiozolidinediones whether taken independently or in some combination usually work very well and can be tolerated by most patients, particularly if they have been taught when to take them and what to do to avoid their side effects. As an example, none are likely to cause hypoglycemia, a sometimes very serious consequence of taking a sulfonylurea, particularly in the elderly, or cause weight gain as sulfonylureas typically do. At present it is unclear whether SGLT2 inhibitors put the patient at a higher risk for urinary tract infections.
What I would call the big three of the older antidiabetes medication classes, the sulfonylureas, biguanides and TZD’s work pretty well for most people with diabetes and they are inexpensive.
The cure lies in a true understanding of the underlying cause (which is impaired insulin and leptin sensitivity) and implementing simple, inexpensive lifestyle adjustments that spell phenomenal benefits to your health.
In other words you NEED insulin to live, and normally your pancreas does its job of providing your body with just the right amount.
He may even explain to you that this is necessary because insulin regulation plays such as an integral role in your health and longevity. Similarly, in humans, when you become leptin resistant, that mimics leptin deficiency and it becomes easy for you to rapidly gain weight.
The only known way to reestablish proper leptin (and insulin) signaling is through your diet. Johnson reviews this fascinating topic in the video below, in which he carefully explains how consuming fructose activates a powerful biological switch that causes us to gain weight. The overwhelming amount of fructose in the standard American diet is a major factor in the rise of diabetes rates in this country. But in fact, healthy food could easily be more affordable for everyone, if not for subsidies like this and the agribusiness CEOs, their lobbyists and the politicians making the subsidies happen. Avandia hit the market in 1999, after the mounting of a multimillion-dollar ad campaign that made it a blockbuster drug.
It specifically reduces your blood sugar by raising the sensitivity of your liver, fat, and muscle cells to insulin.
Focusing on the symptom of diabetes (which is elevated blood sugar) rather than addressing the root cause is an exercise in futility and could even be downright dangerous.
Conventional diabetes treatment has failed over the last 50 years partly because of its seriously flawed dietary principles. In a groundbreaking study comparing processed meats to unprocessed meats for the first time,7,8 researchers at Harvard School of Public Health found that eating processed meat is associated with a 42 percent higher risk of heart disease and a 19 percent higher risk of type 2 diabetes. Every bit as important as your fasting blood sugar, your fasting insulin level, or A1-C, should be between 2 and 4.
It will likely take decades before health policy catches up with what overwhelming scientific evidence has already revealed about the benefits of vitamin D, and before increased sunlight exposure becomes the norm. It is possible to control or reverse your diabetes without drugs by recovering your insulin and leptin sensitivities. Treatment with glucose-lowering drugs actually showed the potential to increase your risk of death from heart-related and all other causes. Aside from legumes, you actually want to AVOID all the rest to prevent insulin resistance. Drinking just one sweetened drink a day can raise your diabetes risk by 25 percent compared to drinking one sugary drink per month, so you really need to evaluate your diet and look for hidden sources of sugar and fructose. You especially need to avoid processed meats which, along with added sodium, have sugar in them to make them palatable.


To avoid becoming a dismal statistic, you merely need to make some lifestyle changes and be mindful about your habits from day to day. Effect of Rosiglitazone on the Risk of Myocardial Infarction and Death from Cardiovascular Causes. Red and Processed Meat Consumption and Risk of Incident Coronary Heart Disease, Stroke, and Diabetes Mellitus. Eating Processed Meats, but not Unprocessed Red Meats, May Raise Risk of Heart Disease and Diabetes.
Trans Fatty Acid Intake Is Associated with Insulin Sensitivity but Independently of Inflammation.
Glycemic Changes after Vitamin D Supplementation in Patients with Type 1 Diabetes Mellitus and Vitamin D Deficiency.
Serum 25-Hydroxy Vitamin D: A Predictor of Macrovascular and Microvascular Complications in Patients with Type 2 Diabetes.
Vitamin D Status in Relation to Glucose Metabolism and Type 2 Diabetes in Septuagenarians. SGLT2 inhibitors and DPP-4  inhibitors are two of the newest classes of antidiabetes medications in the growing list of treatments for type 2 diabetes.
This, of course  is an all time high but certainly will grow even higher with other predictions saying that one out of three children born in 2000 will develop diabetes in their lifetime. When you consider that data from the National Health and Nutrition Examination Survey revealed that only a little over half of the people with diabetes were able to maintain acceptable blood glucose control it makes sense to push forward.
It’s amazing to me how much better equipped we are today to treat both type 1 and type 2 diabetes and their complications than just twenty years ago.
A major advantage of these older, established medications is that they are far more affordable than the newer ones. The downside is that they have more side effects than the newer classes of medications mentioned above.
Type 1 diabetics need to be supplemented with insulin for the rest of their lives as failure to do so will rapidly result in death. But certain risk factors and other circumstances may put your pancreas at risk of not functioning properly. He might add that elevated glucose levels not only are symptoms of diabetes, but also of heart disease, peripheral vascular disease, stroke, high blood pressure, cancer, and obesity. Ultimately, what this means is that diabetes is both a disease of insulin and of a malfunction in leptin signaling. And I promise, your diet can have a more profound influence on your health than any known drug or modality of medical treatment.
Metabolically, this is a highly beneficial capability that allows many species, including humans, to survive times of food scarcity. While glucose is designed to be used by your body for energy (regular sugar is 50 percent glucose), fructose breaks down into a variety of toxins that can devastate your health. Government subsidies have also allowed corn to become a staple in animal feeds, which means even animal-based foods like conventionally-raised meats are tainted or nutritionally altered by HFCS. Interestingly, they did not find any risk of heart disease or diabetes among individuals eating unprocessed red meat such as beef, pork, or lamb.
The more good bacteria you have, the stronger your immunity and the better your overall function will be.
The only known way to reestablish proper leptin and insulin signaling is through a proper diet and exercise. Nearly all type 2 diabetics need to swap out their grains and sugars for other foods, such as protein, green veggies, and healthy sources of fat. Individual articles are based upon the opinions of the respective author, who retains copyright as marked. Still another estimate is that by the year 2030, 5% of the population worldwide will have diabetes. And with 180 new diabetes medications in development, better medical management of diabetes is promising. In regards to the newer classes of medications,  they have less side effects which can make them safer to use, but are more expensive and therefore may be inexcessible for many patients.
At the current time, other than a pancreas transplant there is no known cure for type 1 diabetes. You just might be surprised to know that you can eat, exercise, and live your way to recovery.
Optimize your gut flora by consuming fermented foods like natto, miso, kefir, raw organic cheese, and cultured vegetables. If you choose to do the latter, have your vitamin D levels routinely tested by a proficient lab to see if you are within the therapeutic range.
There is NO drug that can currently accomplish this, and I doubt if one will ever exist in the lifetime of anyone reading this!
The information on this website is not intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. 3 His book, The Fat Switch, shatters many of our age-old myths about diet and weight loss.
It is intended as a sharing of knowledge and information from the research and experience of Dr. Mercola encourages you to make your own health care decisions based upon your research and in partnership with a qualified health care professional.
If you are pregnant, nursing, taking medication, or have a medical condition, consult your health care professional before using products based on this content.



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