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You would think there was a good size writing team that would compare to any top sitcom hit on television  You might even think their aspirations were to enter the movie industry or take on the stand-up comedy circuit.  You might even think there is a huge amount of people dancing around comedy central and dancing with ideas to make us all laugh. The outlook on life by these two women with T1 diabetes is simply stated but at the same time so difficult for so many to master.  They have mastered it, and aren’t we the fortunate ones? With anything as good as this, expansion continues to increase their visibility now with a Memes Twitter account and also a Tumblr Memes as well. Enter your email address to subscribe to this blog and receive notifications of new posts by email.
The Diabetes Forum - find support, ask questions and share your experiences with 209,001 people. We can brand all posters for your organisation, surgery or business should you require it.
Find support, ask questions and share your experiences with 209,001 members of the diabetes community. 10 week (free) low-carb education program developed with the help of 20,000 people with T2D and based on the latest research. The first comprehensive, free and open to all online step-by-step guide to improving hypo awareness. Diabetes is a chronic disease that occurs either when the pancreas does not produce enough insulin or when the body cannot effectively use the insulin it produces. The World Health Organization (WHO) estimates that 350 million people currently suffer from diabetes worldwide. Treatment of diabetes includes measures to lower blood glucose levels and other risk factors that damage blood vessels. Weight control, diet, exercise and other health-promoting lifestyle choices can prevent type 2 diabetes from occuring in the first place. The online journal, BioMed Central, has recently published a nationwide survey on diabetes in the United States that includes a detailed state-by-state breakdown.
I appreciate Diabetes Forecast’s effort at tackling the great carbohydrate debates in: “Are Carbs the Enemy?” (March 2011). With the increasing conversation about pre-diabetes and type 2 diabetes, you’ve likely heard the terms “insulin resistance” and its “opposite insulin sensitivity.” Another term that’s entered our lexicon with the epidemics of obesity and type 2 diabetes is “metabolic syndrome,” a group of symptoms, which, at its core, is insulin resistance. The Health News and Reviews section addresses current health- and lifestyle issues as they are discussed in the press and respective publications. Almost anyone who has ever gone on a diet or bought into a weight loss program knows that lasting success is the real challenge. Science, Technology and Medicine open access publisher.Publish, read and share novel research.
Antioxidant Therapies for Hypolipidemia and HyperglycemiaDawei Gao[1] Key Laboratory of Applied Chemistry in Hebei Province, Department of Biological Engineering, Yanshan University, Qinhuangdao,, China1. But one of the most successful sites out there, providing a good laugh (or at the very least a huge smile) is run, in actuality, by two women in college studying english and environment science.
I am not a medical professional and any medical written word is read somewhere else and will be credited accordingly.
Type 1 diabetes is characterized by deficient insulin production, often developed at a young age. While type 1 diabetes patients require daily insulin injections, type 2 diabetics can benefit from other forms of treatment as well, such as weight management and blood pressure control.
The results are not surprising and confirm more or less what researchers have known for quite some time: Diabetes continues to be on the rise everywhere in America, and the situation is the worst in the southern parts of the country.
You measure your blood sugar, take your diabetes medications, drag yourself out of bed early to walk around your neighborhood and take the extra time to pack your lunch.
The Eating Lighter – Eating Smarter program offers easy modifications of many popular meal choices.
Having lunch or dinner out should be a pleasurable experience, unspoiled by guilt and regret.
Flow cytometric analysis of Nrf2 expression in the liver tissues of lactic acid bacteria treated mice and control mice.
The causes of  type 1 diabetes are not yet fully understood and the disease is neither preventable nor curable at this point in time. If kept untreated, the risk of progressing from gestational diabetes to type 2 diabetes is real. And with so much to learn, you read everything you can find about diabetes and listen to everyone’s well-meaning advice and personal stories. It’s National Nutrition Month with the theme – “Eat Right with Color” (it’s hard to create a color palate without fruits and vegetables!). I also appreciate the dual challenges, for people with prediabetes and diabetes, of glucose control and healthy eating. We like to really appreciate the good things that have come out of it, rather than dwell on the bad. Over time, it can lead to serious damage to many of the body’s systems, including nerves and blood vessels.
Do you suffer from diabetes, have serious blood sugar and insulin imbalances, monitor your blood sugar all the time, or have elevated cholesterol, blood pressure, and triglyceride levels? Formerly only known to occur in adults, type 2 diabetes is now also on the rise in children and adolescents. But what might not be so obvious is that a lot of what you read and hear is just plain wrong. Diabetes mellitus (DM) can be defined as a group of syndromes due to defects in pancreatic secretion of insulin or insulin action, which characterized by hyperglycemia, altered metabolism of lipids, carbohydrates and proteins along with an increased risk of complications from vascular disease (Taskinen et al., 2002).
Free radicals react with lipids and cause peroxidative changes that result in enhanced lipid peroxidation (Girotti, 1985). The level of lipid peroxidation in cells is controlled by various cellular defense mechanisms consisting of enzymatic and nonenzymatic scavenging systems. The efficiency of the antioxidant defense mechanism is altered in diabetes (Wohaieb and Godin, 1987). Increased free radical production exerts cytotoxic effects on the membrane phospholipid, resulting in formation of toxic products such as MDA. The antioxidant scavenging enzymes superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX) offer protection to cells and tissues against oxidative injury (Bonnefont-Rousselot et al., 2000).


There are various reports indicating the bene?cial effects of antioxidant supplementation in preventing dyslipidemia. Some herbal drugs are a good source of natural antioxidants, and increased utilization of medicinal plants became a World Health Organization policy on 1970. Bor (Chinese Name: Hong jing tian) is a traditional Tibetan pharmacology, which distributed in Eastern Europe and Western Asia (altitude 3500-5000 meters).
We found that RS could significantly stimulate insulin secretion, and possess antioxidative and antidiabetic potentials.
Ligustrum lucidum Ait (LLA) is a traditionally Chinese medicinal plant, known with a local name as “Nv zhenzi”. It has been used to treat cancer whose tumor inhibitory rate was 46.15% (Xiang and Gu, 2002). The hypoglycemic effect of oleanolic acid (OA) isolated from LLA was identified in streptozotocin-induced diabetic rats, at the same time, the ability of LLA stimulating secretion of insulin was disclosed in our study (Gao et al., 2007). In order to reveal the efficacy of LLA in alloxan-induced diabetic rats, the effects of OA from LLA were estimated on hypoglycemia, lipids modulating and antioxidant efficacy in alloxan-induced diabetic rats.
Meanwhile, we investigate the effect of OA on serum level of hepatic enzymes and tissue level of lipid peroxidation and antioxidant enzymes in alloxan-induced diabetic rats.Nuclear factor erythroid 2-related factor 2 (Nrf2) controls the antioxidant response element (ARE)-dependent gene regulation in response to oxidative stress. Nrf2 regulates the transcriptional activation of more than 200 antioxidant and protective genes that constitute the so-called phase II response.
A number of Lactobacillus species, Bifidobacterium sp, Saccharomyces boulardii, and some other microbes have been proposed as and are used as probiotic strains, i.e. Fermented cabbages, one of the most important foods in the traditional Chinese diet, hold a wide variety of LAB which may have interesting features for application in health. Fermented cabbages have made up a significant part of food intake in Asia countries for several centuries, including China, Japan, Korea, and so on. In our study, 28 LAB strains were isolated from pickled cabbage, and two strains with high acid tolerance and bile salt resistance were screened, which were Lactobacillus plantarum and Lactobacillus brevis. Activities of antioxidant enzymes in liver and kidney tissues were observed, parameter of blood lipid was examined, and their effects of hypoglycemia and hypolipidemia were analyzed. The experiment was designed to determine whether the antioxidative effects of lactic acid bacteria from fermented cabbage are mediated, at least in part, by the activation of Nrf2. We analysed the scavenging effects of superoxide anion radicals and hydrogen peroxide of the strains isolated from fermental cabbages in vitro, and evaluate liver antioxidative activities related to the elimination of reactive oxygen species in L.plantarum-treated high-fat diet mice. Meanwhile, the Nrf2-mediated antioxidant defense pathway and immune status of the lactic acid bacteria-treated mice were investigated.The present study was performed to investigate the antioxidant therapeutic effects and mechanism of R.
We found that they could significantly stimulate lipid metabolizing, and possess antioxidative, hypolipidemic and hypoglycemic potentials.
Antidiabetic and antioxidative potentials of Rhodiola sachalinensis polysaccharideRhodiola sachalinensis has been used as one of Tibet traditional herbs, which possesses anti-fatigue, anti-lacking oxygen, anti-microwave radiation and anti-caducity potentials. In the study, we examined the antidiabetic effect and probable mechanisms of Rhodiola sachalinensis root extract (RS), its main compound was polysaccharide.
The levels of serum total cholesterol (TC) and triglcerides (TG) of RS-treated diabetic rats were lower than control diabetic rats. A significant enhancement in the serum insulin levels of diabetic rats following RS treatment was also observed. Furthermore, RS treatment decreased malondialdehyde (MDA) level, while increased SOD, CAT and GSH-px activities of the liver and kidney of diabetic rats. At the same time, RS has not expressed significant toxicity in LD50 test and single cell gel electrophoresis assay.
These results indicate that RS has the hypoglycemic and hypolipidemic activities, which is an effective scavenger of free radicals to inhibit the lipid peroxidation.
The abilities of antioxidation and protecting pancreatic ? cells might be the main mechanisms of RS on antidiabetic effect. After filtering the residue was air-dried and then refluxed again with 80% ethanol to remove monosaccharide and oligosaccharide.
After filtering and centrifuging, the precipitate was collected and vacuum-dried, obtaining light brown extracts, named RS. The extract was examined by thin layer chromatography (TLC) analysis to identify the main compounds. Nine kinds of indicator system were used to identify the compounds of RS, and different color spots were visualized (Gao et al., 2009). The results were shown on Table 1, which indicated that the main compound in RS was polysaccharide, meanwhile including a little of flavone, saponin and organic acid, but no alkaloide, anthraquinone, hydroxybenzene, terpene, steroid and lignin were detected.
These results have indicated that polysaccharide is the main ingredient of the extract of R. Preparation of STZ-induced diabetic ratsMale wistar rats weighing 180-200 g were obtained from the animal department of Beijing institute of traditional medical and pharmaceutical sciences. Following one week of acclimation, eight rats were randomly assigned as normal control group, and the rest rats, treated with STZ, became the diabetic model rats according to the standard method (Gao et al., 2007). Blood samples were taken at 30, 60, 90, and 120 min intervals following glucose administration, and blood glucose levels were measured at various time points. However, the blood glucose levels in diabetic control rats declined after 90 min, but it was still high during the experiment.
On days 0, 10, 20, 30 and 40, the blood samples were collected from rat’s tail veins and measured, followed by an overnight fast. Changes of plasma glucose level as a result of RS treatment for 40 days are shown in Figure 2.
They were consistently staying at similar levels within the experimental course in NC & DC groups.
In a healthy person, plasma glucose concentrations are maintained within a fairly narrow range in the fasting state, even if no food is ingested for many days. However, after glucose intake an acute increase in plasma glucose is seen, the concentration peaking generally within 1 h.
Plasma glucose then decreases and fasting levels are regained by 2 h post ingestion (Choi, et al., 2008).
Determination of effects of RS treatment on blood biochemical parametersAt the end of the experiment, the blood samples of fasted tested rats were collected from the eyes under ether anaesthesia, to determine the levels of TG, TC and insulin, according to commercial advice by the Automatic Biochemical Analyzer.


The situation of insulin secretion of the diabetic rats has been ameliorated by RS treatment (Figure 3). The levels of serum lipids are usually raised in diabetes mellitus (Sakatani et al., 2005). The increase of blood glucose is accompanied with the rise of TC and TG (Sharma et al., 2003). The significant rise of blood glucose, TC and TG levels has been observed in STZ-induced diabetic rats, whereas those were significantly decreased by RS treatment. Our results suggested that RS not only possess significant hypoglycemic ability but also have remarkable hypolipidemic effect. RS also enhanced serum insulin release in STZ-diabetic rats by 40 days treatment, which was obviously different with the diabetic control rats. We presume that RS appears the hypoglycemic effect in diabetic rats is partly attributed to its stimulation of insulin secretion. Determination of tissue antioxidative enzyme activitiesThe animals were sacrificed under ether anaesthesia. Their liver and kidney tissues were immediately removed, washed using chilled saline solution, homogenized in 4 volumes of Tris-HCl buffer (pH 7.4). The protein concentrations of the homogenates were determined by the Bradford method using bovine serum albumin as the standard (Bradford et al., 1976).
The levels of SOD, MDA, CAT and GSH-px were measured by commercial suggestion of the kits, and the results are shown in Table 3.
In STZ-diabetic animals, STZ generates nitric oxide, which is a powerful free radical oxidant (Kwon et al., 1994) resulting in an increase in blood glucose level.
Free radicals can diffuse intracellularly and result in mitochondrial enzyme damage and DNA break, impair cellular function and contributes to the pathophysiology of diabetes (Bonnefont-Rousselot et al., 2000). Several reports have shown the alterations in the antioxidant enzymes during diabetic condition (Preet et al., 2005).
The antioxidative defense system like SOD and CAT showed lower activities in liver and kidney during diabetes.
The decreased activities of SOD and CAT may be a response to increased production of H2O2 and O2– by the auto oxidation of excess glucose and non-enzymatic glycation of proteins (Argano et al 1997).
Pigeolet et al (1990) have reported the partial inactivation of these enzyme activities by hydroxyl radicals and hydrogen peroxide.
The decreased activity of SOD and CAT could also be due to their decreased protein expression levels in the diabetic condition as reported recently in liver (Sindhu et al 2004). GSH is often regarded as antioxidant agents, since they protect protein –SH groups against oxidation and can scavenge oxygen radicals and some other reactive species (Robertson, 2004). In these reactions, two GSH molecules transform into one molecule of oxidized glutathione (GSSG). In our research, the level of SOD, GSH-px and CAT was increased and the concentration of MDA was decreased after RS treatment, which suggests that RS has effective antioxidative properties and could scavenge well excess free radicals, which may prevent the oxidative damage of the tissues and can increase a protective effect on improving diabetic complications.
It is a rapid, simple, visual and sensitive technique for measuring DNA breakage in individual mammalian cells.Single cell gel electrophoresis (SCGE) experiment was made.
The blood samples were collected from five rats, then lymphocytes were separated from whole blood using a Ficoll Paque lymphocytes separation medium, then suspended in PBS (Collins and Dusinska, 2002). Electrophoresis was conducted at 25 V for 20 min, and then the slides were washed gently to remove alkali and detergents with Tris-buffer, rinsed with dH2O, and stained with ethidium bromide. Four different cultures were analyses under a fluorescence microscope, the tail lengths of 300 cells per culture evaluated and categorized. In our study, the results showed that RS had not toxic effect to the cultured lymphocytes’ DNA, which were similar with dH2O-treated. Visual classification of DNA damage, accoding to the relative proportion of DNA in the tail (cells 0-4), obtained by single-cell gel electrophoresis. Antidiabetic and antioxidant effects of oleanolic acid in diabetic ratsOur study evaluates the antidiabetic and antioxidant effects of oleanolic acid (OA) from Ligustrum lucidum Ait in alloxan-induced diabetic rats. The levels of serum TC, TG and low-density lipoprotein cholesterol (LDL-c) of OA-treated diabetic rats were lower, and the high-density lipoprotein cholesterol (HDL-c) level was higher than control diabetic rats. Furthermore, OA treatment decreased MDA level, while increased SOD and GSH-Px activities of the liver and kidney in diabetic rats. These results indicate that OA has the hypoglycemic, hypolipidemic and antioxidant efficacy for the diabetic rats and protects the liver function avoiding alloxan induced damage.
The antioxidant ability of OA might be the main mechanism of hypoglycemic and hypolipidemic effects. Sample preparation and characterizationThe extraction of Ligustrum lucidum Ait was based on the multi-crystal method (Gao et al., 2007), and the white powder was obtained. The mass spectrometric analysis results were in agreement with the molecular characteristics of OA.
Preparation of alloxan-induced diabetic ratsWistar rats weighing 180-200 g were purchased and house as previous condition. Eight rats were randomly picked up as normal control (NC), and the rest were fed on high-fat diet. After injection 72 h, the fasting blood glucose level of the rats was determined according to glucose oxidase method (Trinder, 1969) using a Glucose Analyzer. Determination hypolipidemic effect of OAThe rats of DC, DM + OA LD and DM + OA HD groups were fasted overnight with free access to water, blood glucose level of each animal was determined as zero-time blood glucose. The animals of DC group were received 0.5% carboxymethylcellulose (CMC) solution by gavage.
Blood samples of all the rats were taken at 0.5, 1, 2, 4 and 6 hour intervals following the administration and blood plasma glucose levels at various time points were measured. On day 0, 10, 20, 30 and 40, blood samples were collected from a tail vein, following overnight fasting, and measured.The supplement of OA improved the acute blood glucose levels in the rats (Figure 6).
They were consistently staying at similar levels within the time course of 0 to 40 days in NC group and DC group.



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