Type 2 diabetes drug market growth,s ochtends koffie drinken,eating a lot of sugar cause diabetes,type 1 diabetes natural healing 3.5 - Easy Way

The global type 2 diabetes market is heating up, as obesity increases and incidents of diabetes approach epidemic proportions globally. The global market for diabetes therapeutics and diagnostics (including devices for diagnosis and monitoring, as well as therapeutic agents) is expected to climb from $110 billion in 2011 to nearly $157 billion by 2017, according to BCC Research. In the past seven years, two novel drug classes have been introduced—SGLT-2 inhibitors and GLP-1 receptor agonists. In January, Boehringer Ingelheim and Eli Lilly trumpeted topline Phase III results showing that once-daily 10 and 25 mg dosages of empagliflozin met the trial’s primary efficacy endpoint, namely significant change in HbA1c from baseline compared to placebo. Glucagon-like peptide-1 (GLP-1) receptor agonists, a new drug class introduced in 2005, also are interesting.
Novo Nordisk, one of the biggest suppliers of insulin, submitted an NDA in November for Tresiba® (degludec), which offers extended dosing but increases cardiovascular risks. Already, Eli Lilly’s once-weekly GLP-1 therapeutic, dulaglutide, is garnering favorable Phase III trial results. Intarcia Therapeutics' delivery system is a matchstick-sized device consisting of a cylindrical titanium alloy reservoir.
MannKind is developing an inhaled insulin that is expected to enter in the market in one to one-and-a-half years. Diabetes therapies are well-reimbursed, but there is increasing pressure to limit costs and for new therapies to demonstrate strong clinical benefits.
Canaglifozin, the generic name for the new medication, works by blocking the action of SGLT, which allows the blood sugar circulating in the blood to remain in the blood stream during filtration by the kidneys. Invokana received approval after nine clinical trials involving more than 10,000 participants where the drug demonstrated improvement in both fasting blood glucose levels and hemoglobin A1C levels.
Johnson & Johnson is currently seeking approval for the new medication in Europe, where it would become the second such drug in its class to dapagliflozin, a Bristol-Myers Squibb and AstraZeneca product that was rejected approval in the United States due to safety concerns. Sales totaling $111 million in 2013 and up to $667 million by 2016 have been predicted by Lawrence Biegelsen of Wells Fargo.
The studies will evaluate heart-related outcomes, serious cases of pancreatitis, any malignancies that develop, severe allergic reactions, liver abnormalities, adverse pregnancy outcomes, bone safety, photosensitivity reactions and two pediatric studies. The Journal of the American Medical Association’s Internal Medicine reported results of a study that revealed baby boomers have a higher risk for chronic diseases, including diabetes, than do their parents despite the advances of health care over the lifespan of the boomers.

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Data are estimates for the seven major pharmaceutical markets (US, Germany, UK, France, Italy, Spain and Japan).
Although more than 40 diabetes therapeutics are approved for type 2 diabetes, there are high levels of unmet need, creating opportunities for companies in the secondary and tertiary treatment segments that address such complications as cardiovascular disease, peripheral neuropathy, and blindness. Mostly, drug development companies are focusing on neurosalvage, cardiovascular protection, and lipid management, all of which help prevent complications,” according to T.
Of novel therapeutics, the SGLT-2 inhibitors are among the most exciting because they cause patients to excrete extra glucose through the urinary system, Dr. Trade named Ryzodeg®, it combines insulin degludec and insulin aspart to treat type 1 and type 2 diabetes. Once inserted under the skin, water from the extracellular fluid enters the device at one end, by diffusing through a semi-permeable membrane directly into a salt osmotic engine that expands to drive a piston at a controlled rate of travel. For example, Intarcia Therapeutics is developing a GLP-1 receptor agonist implant, ITCA-650. Food and Drug Administration approved the first of a new type of medication to treat type 2 diabetes. This medication inhibits that normal process, allowing the kidneys to instead filter out excess blood glucose for excretion in the urine the U.S. Fasting blood glucose lab testing measures the about of sugar circulating in the blood that is representative of current blood glucose levels; hemoglobin A1c lab testing provides an average of circulating sugar in the blood over a period of three months. FDA has required that Johnson & Johnson conduct five post-marketing studies for canaglifozin due to findings that occurred during the initial nice clinical trials, but whose incidence was deemed as not significant to the approval process by the federal agency. The results of these studies will aid in determination of whether the medication continues to fall within safety standards and what warnings or precautions should be observed with its use. Rapid expansion for the global diabetes market is expected during at least the next decade.
It received positive reviews from the European regulators in October 2012 and by Japanese regulators in December 2012. This forces the drug formulation to be released in a slow and consistent fashion through the exit port, or diffusion moderator, at the other end of the device.

This small osmotic pump is implanted subcutaneously and delivers therapeutics for nearly one year.
Nearly 26 million people have diabetes in the United States alone, and some 347 million people have the chronic disease worldwide, with type 2 diabetes being the most common form of the condition. Both are tests that health care providers use as parameters to diagnose and treat diabetes. By 2017, the T1D market is predicted to grow modestly, which reflects increasing disease incidence and minimal population growth. Normally, 99% of filtered glucose is reabsorbed by the kidney, thanks to sodium-glucose co-transporters (SGLT). GSK also has an IL18 monoclonal antibody in Phase I trials for type 2 diabetes and inflammatory bowel disease, and an ileal bile acid transfer inhibitor for type 2 diabetes also in Phase I trials.
Lilly also is developing a PEGylated version of its own short-acting insulin, Humalog®. In November, the company raised $210 million in financing, enabling global Phase III trials to begin the first quarter of 2013.
Additionally, since 2007, the FDA mandates that diabetes therapies be evaluated for cardiovascular risk. Insulin sales will dominate, and sales of immunomodulators (b) will be limited owing to the current stage of development, safety issues and the small patient population (recent-onset T1D).
By administering GLP-1 therapeutics, physicians can administer less insulin for the same effect, lower the risk of hyperglycemia, and prevent the associated weight gain.
Nonetheless, Decision Resources predicts that the class will experience strong growth during the next decade. In Phase II trials, early results support once-daily administration and show weight loss in patients. Patients taking MKC253 do not develop the nausea and other side effects typically associated with GLP-1 analogs.

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