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Type 2 diabetes is caused by a continuous deterioration of the insulin-secretory capacity of pancreatic β-cells, which does not allow compensation for an increased peripheral insulin demand.
Endocrinology, Diabetes & Metabolism, University Hospital Basel, Petersgraben 4, CH-4031 Basel, Switzerland. Jardiance (empagliflozin) is a once daily tablet indicated for the treatment of adult patients with type 2 diabetes. Jardiance's action mechanismJardiance consists of empagliflozin, a sodium glucose co-transporter-2 (SGLT2) inhibitor. Jardiance contains empagliflozin, which works by blocking glucose reabsorption capacity of the kidneys. Washington, Sept 20: Researchers from Stanford University have revealed that type 1 diabetes may not be due to bad genes but rather to good genes behaving badly. Previous studies in identical twins have revealed that often one twin develops type 1 diabetes while the other twin remains disease-free, this may be due to how genetically at-risk individuals respond differently to environmental stimuli. Washington, September 16 : Virginia Tech researchers have uncovered a common connection between the cellular innate immunity network and chronic inflammatory diseases like atherosclerosis, Type 2 Diabetes, and neurodegenerative diseases. Research leader Liwu Li, an associate professor of Biological Sciences, says that the new finding offers a viable cellular and molecular target for the diagnosis and treatment of serious human inflammatory diseases.
London, Sept 16: Drinking chamomile tea daily can help prevent the complications of diabetes, which include loss of vision, suggests a new study. London, Sept 8: A breakthrough at the Research Institute of Mount Sinai Hospital may soon get many diabetics rid of the misery of taking insulin injections twice a day, for the researchers there have developed a once-a-week jab for type 2 diabetes patients. Washington, Sept 5 : A new study has found that obesity and Type 2 Diabetes Mellitus (T2DM) can contribute to mild neurodegeneration with features common with Alzheimer''s disease (AD). Researchers at Rhode Island Hospital say their study is the first one to show that obesity can cause neurodegeneration. In a study on animal models, lead author Suzanne de la Monte, MD, MPH, of Rhode Island Hospital, utilized chronic high fat diets to cause a two-fold increase in mean body weight. London, September 2: Amid rising concerns that the current number of about 170 million diabetics across the world may double up by 2030, researchers at Johns Hopkins University in Baltimore have developed a reliable test to spot the disease in the early stage so that its progression can be prevented. Washington, Aug 29 : A certain class of oral drugs used to treat type 2 diabetes can double the risk of heart failure in patients, warn a group of group of researchers led by an Indian origin researcher. Washington, Aug 28 (ANI): A new study from led by Indian origin researchers has found that young men with type 2 diabetes have significantly low levels of testosterone, which can have a critical effect on their quality of life and on their ability to father children. Washington, Aug 27: Researchers at the Stanford University School of Medicine have offered new insight into how type-1 diabetes begins.
An autoimmune attack on the pancreas causes type-1 diabetes, but the exact trigger of the attack has not been unclear.
London, Aug 26: Babies born by Caesarean section have a significantly higher risk of developing diabetes in childhood, a new study suggests. Although the reason for the link is not clear, scientists believe exposure to hospital bacteria may be involved. Washington, Aug 21 : Kids and young adults, who become diabetic, should blame their parents, for a new study has found that the condition is inherited.
Researchers suggest that unusual form of inheritance might play a role in the increasing rates of diabetes, especially in children and young adults.
Washington, Aug 20: A new study by researchers at the Johns Hopkins Bloomberg School of Public Health has found that inorganic arsenic, commonly found in ground water in certain areas, may increase the risk of developing type 2 diabetes.

In the study, researchers found that individuals with diabetes had higher levels of arsenic in the urine compared to individuals without diabetes. Washington, Aug 13 : A new study has found that people who lose weight soon after a diagnosis of type 2 diabetes have better control of their blood pressure and blood sugar, and are more likely to maintain that control even if they regain their weight.
This is the first clinical study to show that benefits remain even if patients regain their weight. London, Aug 11 : Diabetes is linked to one in 10 deaths among the bulk of the population in England, according to new figures. In most cases, the disease indirectly kills by leading to strokes, heart attacks or kidney failure. Washington, July 29: A new study has found that women with gestational diabetes are more likely to develop type 2 diabetes, with almost 20 percent developing the condition within 9 years of pregnancy. London, July 28 : Men really should learn how to relax and forget their worries, for a new Swedish study suggests that it can up the risk of them developing diabetes. Washington, July 25 : Researchers at the University of California, Irvine found a molecular link between circadian rhythms, our own body clock, and metabolism – a iscovery that will lead to treatments for diabetes, obesity and other related diseases. Washington, July 16: Diabetes could be a hidden condition for some patients with coronary heart disease, says a new research conducted by scientists at the University of Warwick.
The study, led by Dr Saverio Stranges, Associate Professor of Cardiovascular Epidemiology at Warwick Medical School, looked at levels of oxidative stress in the body (a toxic effect which causes cell damage).
Washington, July 15: Snapshots of eyes, used for detecting eye disease, can also serve as an early warning for diabetes, say researchers.
The device takes a specialized photograph of the eye and is non-invasive, taking about five minutes to test both eyes. Washington, July 9 : A new study has shown that having a higher than normal level of fetuin-A, a protein produced in the liver and secreted into the blood stream, is linked to an increased risk of developing diabetes. Washington, July 9: A dietary study in rats suggests that trans-fats do not increase the risk of insulin resistance and diabetes. Washington, July 2 : A new study is shedding light on processes that determine the release of the blood sugar-lowering hormone insulin, thereby acting as a potential target for developing improved diabetes treatment.
London, June 28 : Monitoring chronic conditions, such as diabetes, through sensors beneath the skin’s surface is quite convenient, but it triggers the fibroblast tissue capsule around the sensor.
Washington, June 19 : A study conducted by American scientists has shown that some adult patients with type 1 diabetes are still capable of producing insulin, and that many of them may live free of any complications like eye, kidney or nerve disease even 50 years after diagnosis.
Washington, June 10 : A new study has shown that people in prediabetic state were 81 pct less likely to convert into type 2 diabetes patients when treated with drug pioglitazone, brand name Actos®.
Toujeo (insulin glargine [rDNA origin]) is an insulin injection approved for the treatment of type 1 and type 2 diabetes to improve glycaemic control in adult patients. Toujeo's mechanism of actionToujeo contains an active ingredient called insulin glargine whose primary activity is to regulate glucose metabolism by controlling high blood sugar levels in patients with type 1 and type 2 diabetes. Toujeo is a US FDA-approved insulin injection to improve glycaemic control in diabetes patients. Toujeo was compared to once-daily Lantus, another insulin injection, in Phase III clinical trials.
Sanofi also manufactures medical devices for diabetes including blood glucose monitoring systems. In healthy individuals, insulin secretion by the pancreatic islet allows for normal glucose disposal in the insulin-sensitive tissues: liver, muscle and adipose tissues (panel a).

Type 2 diabetics are affected by higher blood sugar levels due to the presence of SGLT2s, proteins which are responsible for the reabsorption of glucose into the bloodstream, in higher quantities.Jardiance works by blocking the glucose reabsorption capacity of the kidneys, which results in urinary glucose excretion and thus controls the blood sugar levels in type 2 diabetics.
Childhood infections, along with genetics, are already known to play an important role in the development of type 1 diabetes. For this reason the number of deaths attributable to diabetes has consistently been underestimated. But now, researchers have developed a self-cleaning surface that shakes off the body's defence response enabling the biosensors to work for longer inside the human body.
During prediabetes, genetic predisposition, over-nutrition and physical inactivity reduce the response to insulin-stimulated glucose uptake that is compensated for by an increase in insulin production (panel b). Donath is internationally recognized for his contribution to the understanding of the pathogenesis of type 2 diabetes. Unlike other type 2 diabetes drugs, empagliflozin and other SGLT2 inhibitor class drugs work independently of ?-cell function and insulin pathway.Clinical trials of JardianceThe FDA approval for Jardiance was based on two phase three clinical trials conducted on type 2 diabetics. In patients with type 2 diabetes, insulin secretion no longer compensates for the increased peripheral insulin demand (panel c).
He is Head of the Clinic for Endocrinology, Diabetes and Metabolism at the University Hospital of Basel, Switzerland.
Type 2 diabetes is also known as non-insulin dependent diabetes and accounts for 90% to 95% of all diabetic cases. One study compared the efficacy of Jardiance as a monotherapy with that of a placebo, while the other tested the drug in combination with other diabetes drugs such as metformin, sulfonylurea, pioglitazone and insulin. Good glycaemic control is an important part of diabetes care as both hyperglycaemia (elevated blood sugar levels) and hypoglycaemia (low blood sugar) may lead to chronic complications of diabetes. The progression from prediabetes to diabetes is largely dictated by changes in the islet-secretory capacity, whereas insulin resistance remains relatively constant over time.
The results showed a significant reduction in the haemoglobin A1c (HbA1c) levels of T2D patients.The first trial, in which Jardiance was studied as a monotherapy was a double-blind placebo controlled study, which enrolled 986 type 2 diabetics.
It takes a unique approach of engaging with people suffering with diabetes, derives insights from it and forms a partnership to offer diagnostics, therapies, services and devices. On the basis of this, he initiated a pioneering clinical trial in patients with type 2 diabetes that vindicates his hypothesis and opens the way for the causative treatment and prevention of diabetes and associated complications.Contact Marc Y. The disease is more likely to affect people with a family history of type 2 diabetes, obese people and older people.An estimated 382 million people across the world and approximately 29 million Americans are suffering from either type 1 or type 2 diabetes.
D from University of Michigan Kellogg Eye Centre helps in measuring metabolic stress in retina.
The company markets injectable, inhaled and oral medications for type 1 or type 2 diabetes. In this study, type 2 diabetics who had inadequately controlled blood sugar levels with at least 1,500mg of metformin per day entered an open label two-week placebo run-in. Hypoglycaemia was commonly reported in patients who received a combination of Jardiance and sulfonylurea or insulin. Other side effects included weakness, headaches, confusion, hunger, drowsiness, sweating, kidney problems and a rise in cholesterol.Marketing commentaryJardiance is the third diabetes product developed in collaboration by Boehringer Ingelheim and Lilly Diabetes.

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