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Recent breakthroughs in type 2 diabetes treatments promise new treatment options for type 1 diabetics.
Less than 20 years ago, the only thing type 1 and type 2 diabetes seemed to have in common was a shared name; they were related conditions but only as distant cousins, and once removed, at that.
Doctors and researchers discovered the last decade that, for a variety of reasons, many type 2 diabetics could benefit from taking insulin. There are numerous causes for this, according to Andrea Penney, RN, CDE, with the Joslin Diabetes Center. That change in thinking about the ways type 2 diabetes evolves indirectly opened the door to considering new ways of thinking about how type 1 diabetes behaves. There is only one treatment besides 54 varieties of insulin approved by the Federal Drug Administration for use by type 1 diabetics, according to the University of Maryland Medical Center, and that drug is pramlintide acetate, which is marketed under the name Symlin. Pramlintide is a small peptide hormone produced in the pancreas and, in people without diabetes, is released alongside insulin after meals or food ingestion, to help reduce high blood sugar. According to the FDA, which approved Symlin for use in treating type 1 diabetes in 2005, “Symlim is an injectable medicine for adults with type 2 and type 1 diabetes to control blood sugar. Symlin’s manufacturer, Amylin Pharmaceuticals, Inc., says that Symlin works to reduce blood sugar by generating a feeling of fullness after meals, slowing the rate that the stomach empties after meals, and reduces the release of glucagon from the liver after meals.
Some doctors are also prescribing metformin, which is the most prescribed oral type 2 diabetes treatment in the United States, off label as an adjunct to insulin for type 1 diabetics. Other drugs used to treat type 2 diabetics are being studied to see if they should be submitted to the FDA for approval to treat type 1 diabetics.
GLP-1 is a naturally occurring hormone released in the intestine that stimulates the release of insulin from pancreatic beta cells when carbohydrates are absorbed in the intestine.
Some limited research suggests that GLP-1 treatments might be effective in helping type 1 diabetics better control their blood sugar. A full-scale clinical trial of Victoza on type 1 diabetics is potentially in the works from the maker of Victoza. Then, this January Novo Nordisk started recruiting more than 1,400 subjects for a 52-week trial on the effects of Victoza on type 1 diabetics. Until that trial is completed and the FDA acts, however, Byetta, Victoza, and Bydureon are explicitly not approved for use by type 1 diabetics, according to the product warnings on each drug.
If any type 1 diabetic wishes to try the drugs off label (which is the medical jargon for when patients receive a prescription to use a drug for a purpose for which it has not been FDA approved) researchers and doctors suggest consulting with a qualified endocrinologist experienced both in prescribing GLP-1 drugs and treating type 1 diabetics. Anyway, if this sounds interesting to anyone, they’re currently enrolling people in a year-long study to see if regular treatment with Bydureon (the once-a-week version) is helpful to people with Type 1.
The Diabetes Media Foundation is a 501(c)(3) tax-exempt nonprofit media organization devoted to informing, educating, and generating community around living a healthy life with diabetes.
000This month the American Diabetes Association published the e-book edition of Targeting a Cure for Type 1 Diabetes: How Long Will We Have to Wait?
Back in 2009, Targeting a Cure began as a research project spearheaded by Lisa Rotenstein, who had just joined diaTribe’s parent company as a summer associate. The topics in Targeting a Cure have a least a decade of research ahead of them (except for the artificial pancreas), but they are also vitally important. With a leap forward that sounds like something out of a science fiction movie, researchers last week announced significant progress on perfecting an islet cell transplantation technique that could lead to a cure for Type 1 diabetes.
Researchers have cured Type 1 diabetes in mice by transplanting them with islet cells (the cells in the pancreas that actually produce insulin and which, in a type one diabetic, no longer function) wrapped in a new synthetic biomaterial that enabled the fragile cells to survive infusion, graft to the host, and function successfully. In traditional islet cell transplantation, which has been tested in clinical trials around the world for the last decade, islet cells are infused into a person’s liver. The process of clinical islet transplantation for the treatment of diabetes mellitus by Giovanni Maki licensed under the Creative Commons.
Another significant fallback regarding traditional islet cell transplantation, according to Garcia, is that the cells are not linked via the circulatory system to the body, the way they are in a person whose islet cells function normally. The biomaterial holding the islet cells—which is completely synthetic, is 96 percent water, and which Garcia described as having the consistency of diluted Jello-O—and that was infused into the mice, however, addresses several of these problems. The material acts as a shield to effectively prevent the death of so many islet cells immediately following infusion. The biomaterial is completely synthetic so researchers have a lot of control over how it functions. The biomaterial was further engineered so that as it broke down it also integrated, or grafted, specifically to the surrounding tissue. The success in grafting the islet cells is compelling, but it’s only a first step in a long process, Garcia said.
In what might be described as another breakthrough, although one of a very different type, Garcia said the Juvenile Diabetes Research Foundation is being proactive in enabling research to continue in the field. A new study has shown that the juice of bitter melon, the fruit known in Asia and Africa has significantly reduced the growth of carcinogen tissue as it disrupts the metabolism of glucose in cancer cells, which literally starves his cell without supply of sugar which is the primary fuel, without which can not survive. Although the plant is known for its healing powers, most health benefits (antiviral activity, antioxidant, cure diabetes, anticancer capacity), only very recently become popular in Western medicine.


Juice causes programmed cell death of carcinogens cells (apoptosis) and, more importantly activates the AMPK that is a sign it disables the metabolism inside the carcinogenic cell then becomes it incapable of feeds himself resulting in her death..
The recipe for removal of Unwanted Facial Hair Permanently, which will save you,because it is used for centuries! I can recall a doctor telling me about one of his patients who got very angry with him over an A1C test. But what the A1C test uncovered was that his blood sugar was consistently high throughout the day after meals. If you’re concerned about your A1C numbers you really need to grab my Master Your Diabetes Program.
The moment someone hears I am living with type 2 diabetes, the first question is – what do you eat? But today, when I visited my doctor, she scolded me for taking such radical measures in my diet. Eat your usual foods, but make half of your plate vegetables and fruit, a fourth meat or protein, and another fourth grains or starches, plus a glass of nonfat or low-fat milk. We need carbs in our diet because they provide the fuel we need and give us energy to go about our routine.
With diabetes, it is critical to get the right amount of carbohydrates so that the medication and exercise maintain blood sugar at safe levels. Counting carbs means knowing how to read labels and which foods are carb-rich so you can control your portions. Fiber qualifies as a healthy carb since it does not get digested and does not have a significant effect on blood sugar. The important thing to remember is balancing our food, medication and exercise to manage type 2 diabetes. Eliminating refined and processed foods like bakery items made of white flour, polished rice and white bread as the shoot up blood sugar levels rapidly. Cut your sugar and salt intake as this directly messes up your blood pressure and cholesterol levels. When you have to go out for a few hours, pack a snack so you don’t suffer from low blood sugar. Vi, I or rather we would never be able to ever Thank you enough for such a informative and useful blog posts. This is such a hard disease to manage as my Ex was a Diabetic and so is my mother n law and it makes it hard as sometime with no warning there Blood Sugar drops. We have been changing our diet, too, since my husband had high blood pressure and high cholesterol.
Disclaimer"Be Healthy, Be Happy", this blog, does not provide medical advice, diagnosis or treatment.
Navigating this world of new, and apparently improved drugs, however, is anything but simple or straightforward. The paradigm at the time was that type 1 and type 2 diabetes required different treatments because they were, in fact, very different conditions. The recently realized realities regarding the ways each condition evolves and behaves has led to new ways of treating each type of diabetes and a sharing of therapies between the two. That shift led to considering whether that door swung both ways and if type 1 diabetics might benefit from treatments designed to treat type 2 diabetes. Symlin is recommended for type 1 diabetics who have not achieved good blood sugar control, which is decided on a case-by-cases basis by a person’s physician. These drugs, once-daily injectable Victoza, Byetta, and once-weekly injectable Bydureon, are all GLP-1 agonists.
Additionally, GLP-1 (which stands for “glucagon like peptide”) is also present in the brain, where it acts as an appetite suppressant and produces one of the same effects of taking Symlin. I want to add to Kelly’s experience by saying I was in a tiny, preliminary trial using Byetta, and was astounded by the result.
This new and novel approach of wrapping islet cells in a specially engineered biomaterial addresses several problems with islet cell transplantation that has prevented it from being developed as readily available procedure to cure the nation’s three million Type 1 diabetics. Andres Garcia, a researcher with Georgia Tech’s Petit Institute for Bioengineering and Bioscience who worked on the biomaterials project with researchers from Emory University and in conjunction with the Juvenile Diabetes Research Foundation.
The cells then reside in the liver where they produce insulin and ostensibly “cure” a person of Type 1 diabetes.
This is problematic because the cells are harvested from cadaver pancreases and are not readily available to begin with.
Islet cells require a lot of blood flow to get the insulin they produce into the system when needed. This meant that the cells attached to the body without the use of staples or sutures and surgery was avoided. The JDRF funded a consortium of more than a dozen researchers all working toward the same goal along the same lines.


He underwent an experimental islet cell transplant to cure Type 1 diabetes in 2006. Alex is a regular contributor to ASweetLife. Not only does it give you a snapshot of how you’re doing, but it can serve as a wake-up call. It turned out that this patient only tested his fasting blood sugar in the morning and his blood sugar was usually OK. And the A1C test showed that his blood sugar was averaging very high over a 3 month period.
If your current treatment is working your doctor will usually tell you to do more of the same. What this means is it measures the amount of hemoglobin that attaches to blood glucose to form hemoglobin A1C. For many this goal is too high, but their main concern is low blood sugar or hypoglycemia, which can happen with diabetes treatment that is too aggressive.
In master your diabetes, you’ll learn how to get off the diabetes diet rollercoaster for lowering your A1C, how to get off the drugs, and how to experience lasting blood sugar control.
I have to confess that when I was diagnosed I imagined giving up everything I enjoyed eating – thanks to all the myths I’ve heard.
She advised me to eat as normally as possible, only avoiding specific vegetables, fruits and fried stuff and sugar from my diet. A dietician can help you develop a good meal plan that suits your lifestyle, keeps you satisfied and gives you the right amount of calories. Please let your Mom know that I will be publishing this month’s posts on Living with Type 2 diabetes as an ebook with additional info and will let you know, so you can send her a copy!
In type 1 diabetes the pancreas stops making insulin so type 1 diabetics injected insulin to replace what the body was no longer producing.
Because of the high loss of the cells in the procedure most subjects in clinical trials had to be infused with cells from two or sometimes three separate donors. That not only translates to an increased availability of cells, it also means that only one donor is needed for each patient and a match is easier to find for each patient.
The effect is observed in breast cancer, prostate cancer, colon cancer, liver, stomach, leukemia and more. So the patient was very upset with his A1C test results and argued that the results were wrong. And hemoglobin in the red blood cells bind to elevated blood glucose to form hemoglobin A1C in the red blood cells. Luckily, I am a South Indian vegetarian, which coincidentally happens to be one of the healthiest diets around. Fluctuating carb intake can make blood sugar levels go crazy and it is important to ensure that the same quantity of carbs are consumed with every meal. I see it as a second chance to live healthy by making the necessary lifestyle changes so that I can avoid diabetes complications. It’s pretty simple once people understand the reasons behind what they ought to go easy on or avoid. Type 2 diabetes, however, was a condition in which a person’s pancreas was producing insulin, but their body was not metabolizing and using the hormone efficiently. People can also become insulin resistant due to weight gain or chronic emotional or physical stress. Additionally, each subject must be matched for genetic compatibility with not one, but several donors. For this reason, a hemoglobin A1C test may not be as accurate if you have any hemoglobin abnormalities or conditions. Each individual has a different constitution, different needs and generally, the doctor recommends making changes in what we eat, how much we eat without making drastic changes, unless the situation warrants it.
Type 2 diabetics took oral medications to help improve their ability to metabolize the insulin their bodies were producing.
What’s more, normally, Byetta is thought to work by boosting insulin production (in people with Type 2). But other than that, it is a very effective way to track if your blood sugar is elevated in the long-term (a 2-3 month period), not really for the short term.
But when they analyzed my blood, they found that I was producing LESS insulin on the Byetta day than I was during the regular glucose tolerance tests. Aggressive action is usually necessary to improve beta cell function and reduce insulin resistance. We are really excited by these results so far and are anxious to see if her A1C has gone down!




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Comments

  1. PIONERKA

    Concluded ?˜consumption of a low-carb/excessive-protein weight loss plan for six weeks delivers "quick" results.

    07.08.2014

  2. BARIS

    Glucose readings in the high eighties however.

    07.08.2014