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Over-the-counter cough medicine with dextromethorphan could help people with Type 2 diabetes.
Dextromethorphan, sold in Canada as an ingredient of the over-the-counter cough medicine Robitussin and Bronchophan Forte DM, could help in regulating type 2 diabetes according to a new study.
In mice, this medicine was found to improve glucose control, while in a small human clinical trial (20 men with Type 2 diabetes) the researchers found it increased insulin and lowered blood glucose. Researchers conclude that dextromethorphan could become a useful adjunct treatment for diabetes. Preventable deaths caused by acute kidney injury (also known as acute renal failure) could be eliminated in just 10 years according to an international commission of kidney experts. Using data quantifying Canadian prescription drug use and spending, researchers believe that Canada could save up to $9.4 billion a year by switching to a universal pharmacare program. Who are we?The Science Media Centre of Canada is a registered charitable organization that supports journalists writing about the sciences, engineering and technology. Register with usJournalists click here to get the latest Canadian science (including embargoed material) delivered right to your inbox.
Chives are nutrient-dense herbs, with a low amount of calories and high levels of vitamins, minerals and antioxidants. Best grown in a pot, as it grows to fill whatever space you give it, mint is a very useful herb to have around the house.
Tarragon has been used as a traditional remedy to stimulate appetite and alleviate symptoms of anorexia.
Consider planting this herb in your garden and house just for the smell, if not for its many possible health benefits. Glucobay (Precose)® (acarbose) is an oral alpha-glucosidase inhibitor for use in the management of type 2 diabetes mellitus.
Because its mechanism of action is different, the effect of Glucobay (Precose) to enhance glycemic control is additive to that of sulfonylureas, insulin or metformin when used in combination.
Acarbose has no inhibitory activity against lactase and consequently would not be expected to induce lactose intolerance. In a study of 6 healthy men, less than 2% of an oral dose of acarbose was absorbed as active drug, while approximately 35% of total radioactivity from a 14C-labeled oral dose was absorbed. Acarbose is metabolized exclusively within the gastrointestinal tract, principally by intestinal bacteria, but also by digestive enzymes. The fraction of acarbose that is absorbed as intact drug is almost completely excreted by the kidneys. Studies in healthy volunteers have shown that Glucobay (Precose) has no effect on either the pharmacokinetics or pharmacodynamics of nifedipine, propranolol, or ranitidine. The amount of metformin absorbed while taking Glucobay (Precose) was bioequivalent to the amount absorbed when taking placebo, as indicated by the plasma AUC values.
Clinical Experience in Type 2 Diabetes Mellitus Patients on Monotherapy, or in Combination with Sulfonylureas, Metformin or Insulin: Glucobay (Precose) was studied as monotherapy and as combination therapy to sulfonylurea, metformin, or insulin treatment. A one year study of Glucobay (Precose) as monotherapy or in combination with sulfonylurea, metformin or insulin treatment was conducted in Canada in which 316 patients were included in the primary efficacy analysis (Figure 2). Glucobay (Precose) is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.
There have been no clinical studies establishing conclusive evidence of macrovascular risk reduction with Glucobay (Precose) or any other anti-diabetic drug.
Because of its mechanism of action, Glucobay (Precose) when administered alone should not cause hypoglycemia in the fasted or postprandial state.
When diabetic patients are exposed to stress such as fever, trauma, infection, or surgery, a temporary loss of control of blood glucose may occur.
Patients should be told to take Glucobay (Precose) orally three times a day at the start (with the first bite) of each main meal. Glucobay (Precose) itself does not cause hypoglycemia even when administered to patients in the fasted state. If side effects occur with Glucobay (Precose), they usually develop during the first few weeks of therapy.
Therapeutic response to Glucobay (Precose) should be monitored by periodic blood glucose tests. Plasma concentrations of Glucobay (Precose) in renally impaired volunteers were proportionally increased relative to the degree of renal dysfunction. Patients Receiving Sulfonylureas or Insulin:  Sulfonylurea agents or insulin may cause hypoglycemia.
Intestinal adsorbents (for example, charcoal) and digestive enzyme preparations containing carbohydrate-splitting enzymes (for example, amylase, pancreatin) may reduce the effect of Glucobay (Precose) and should not be taken concomitantly. Glucobay (Precose) has been shown to change the bioavailability of digoxin when they are coadministered, which may require digoxin dose adjustment. Acarbose did not induce any DNA damage in vitro in the CHO chromosomal aberration assay, bacterial mutagenesis (Ames) assay, or a DNA binding assay. In vivo, no DNA damage was detected in the dominant lethal test in male mice, or the mouse micronucleus test. Fertility studies conducted in rats after oral administration produced no untoward effect on fertility or on the overall capability to reproduce. CHEMICAL NAMEGLIPIZIDE.INDICATIONSGlipizide is an anti-diabetic drug (sulfonylurea-type) used along with a proper diet and exercise program to control high blood sugar.
The information on this site is for educational or informational purposes only, and is not intended to diagnose or provide treatment for any condition. Aquatic therapy also known as pool therapy or hydrotherapy is a treatment program that is performed with the help of water.
People, who do not like exercising on the ground due to joint ache, will certainly find it convenient and enjoyable doing exercises in the water. Water being a viscous product, provides very good resistance that can be very useful for the treating a variety of illnesses and problems. Yes, Pool therapy is covered by health insurance, if your health insurance coverage includes physical therapy.
Bring along your bathing suit, dry clothing, applicable footwear like sandals, shoes and a large towel.
Pool therapy is not recommended for people with blisters on the skin, wounds, skin disease, skin eruptions, skin lesions, contagious, infectious diseases, unmanageable seizures, cardiac problems and bowel related problems.
Asbestos cancer, also known as mesothelioma is a form of cancer that is caused by asbestos exposure; this by now is well known. Sadly, asbestos product manufacturers decided to play truant to the health hazards and since asbestos are profitable, they continued manufacturing it. Out of the above two diseases malignant mesothelioma and asbestos lung cancer are the only two serious cancer asbestos diseases which can be directly fatal. Malignant mesothelioma and asbestos lung cancer are confused with each other because both affect similar areas of the chest cavity. Asbestos are naturally occurring minerals that are known for heat resistance, strength and flexibility. If the cancer has metastasized, chemotherapy or the use of particular anti-cancer medication – is the only and best option. Chives contain choline, an important nutrient that helps with sleep, muscle movement, learning and memory.
It can be used as a simple answer to allergies, colds, Irritable Bowel Syndrome and abdominal pains.


Not only does this herb provide food flavor and an amazing smell, it's also high on potent antioxidants and anti-bacterial ingredients. It is a rich source of vitamins such as C, A and B, and other minerals like calcium, manganese, iron and magnesium. Rich in antioxidants and anti-aging properties, basil is a good source of vitamins A, K and C, as well as magnesium, iron and potassium. The inactive ingredients are starch, microcrystalline cellulose, magnesium stearate, and colloidal silicon dioxide. As a consequence of plasma glucose reduction, Glucobay (Precose) reduces levels of glycosylated hemoglobin in patients with type 2 diabetes mellitus. The antihyperglycemic action of acarbose results from a competitive, reversible inhibition of pancreatic alpha-amylase and membrane-bound intestinal alpha-glucoside hydrolase enzymes. In addition, Glucobay (Precose) diminishes the insulinotropic and weight-increasing effects of sulfonylureas.
An average of 51% of an oral dose was excreted in the feces as unabsorbed drug-related radioactivity within 96 hours of ingestion. A fraction of these metabolites (approximately 34% of the dose) was absorbed and subsequently excreted in the urine. When acarbose was given intravenously, 89% of the dose was recovered in the urine as active drug within 48 hours. Glucobay (Precose) did not interfere with the absorption or disposition of the sulfonylurea glyburide in diabetic patients.
However, the peak plasma level of metformin was reduced by approximately 20% when taking Glucobay (Precose)  due to a slight delay in the absorption of metformin.
The treatment effects on HbA1c levels and one-hour postprandial glucose levels are summarized for four placebo-controlled, double-blind, randomized studies conducted in the United States in Tables 2 and 3, respectively.
In the diet, sulfonylurea and metformin groups, the mean decrease in HbA1c produced by the addition of Glucobay (Precose) was statistically significant at six months, and this effect was persistent at one year. Although these differences between treatments were statistically significant, these elevations were asymptomatic, reversible, more common in females, and, in general, were not associated with other evidence of liver dysfunction.
Sulfonylurea drugs and insulin, however, can lower blood sugar levels enough to cause symptoms or sometimes life-threatening hypoglycemia. They are most commonly mild-to-moderate gastrointestinal effects, such as flatulence, diarrhea, or abdominal discomfort, and generally diminish in frequency and intensity with time. Measurement of glycosylated hemoglobin levels is recommended for the monitoring of long-term glycemic control. It is recommended that serum transaminase levels be checked every 3 months during the first year of treatment with Glucobay (Precose) and periodically thereafter.
These drugs include the thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel-blocking drugs, and isoniazid. Glucobay (Precose) given in combination with a sulfonylurea or insulin may cause a further lowering of blood glucose and may increase the potential for hypoglycemia.
Six studies were performed in rats (two strains, Sprague-Dawley and Wistar) and two studies were performed in hamsters.
Acarbose treatment resulted in a significant increase in the incidence of renal tumors (adenomas and adenocarcinomas) and benign Leydig cell tumors. If you have any concerns about your own health, you should always consult with a healthcare professional.
This type of exercise minimizes the stress and joint inflammation, making it easy for unobstructed, painless movement of the body.
Water is the source of life and physical properties of this most useful substance in the world is used to treat injuries, diseases and disorders. Since the amount of weight bearing in water is reduced, there is less stress on the joints and bones.
Cure problems like arthritis: The buoyancy, heat, hydrostatic pressure and friction offered by water can cure problems like arthritis. Effective for fibromyalgia: Pool therapy is effective in treating problems like Fibromyalgia, a problem that can cause pain even when you exert little movement with your fingers.
Ideal for pregnant women: Pregnant women can find a lot of benefits in pool therapy and especially easing labor pain.
Fights Repetitive Stress Injuries: People afflicted with repetitive stress disorders can benefit a lot from pool therapy. This form of therapy uses resistance of water instead of water, which renders it very simple for exercising. The therapy can treat many illness, and some of the disease that are treated include arthritis, Repetitive Strain Injuries, back pain, head injuries, gait disorders neck injury, back injury,, joint replacement, shoulder injuries spinal cord injury, stroke, etc.
There are rooms to change, shower and also locker rooms where you can keep your belonginings. A British Parliamentary Commission way back in 1906 said that there was a connection between people working in asbestos environment and their premature death.
The US Govt has taken a note of it and called ‘asbestos-the worst occupational health hazard in the history of US’ Now asbestos product manufacturers are according to mesothelioma law, responsible for asbestos related cancers and mesothelioma contracted by employees, their families and even the past employees contract. Some of the asbestos related diseases include Malignant Mesothelioma, Asbestos Lung Cancer, Asbestosis, Diffuse Pleural Thickening, Fibrosis and Asbestos Warts. Asbestosis is an inflammatory lung disease that can impair lung functioning and cause heart failure.
Malignant Mesothelioma is the most serious type of asbestos cancer, which affects the mesothelial tissue lining of three large body cavities: the pleura (lung cavity), the peritoneum (abdominal cavity) and the pericardium (heart sac).
Malignant mesothelioma is a cancer that affects the lung cavity whereas asbestos lung cancer is a cancer that affects the parenchymal lung tissue itself. During construction activity, demolition, renovation work etc, the material containing asbestos is stressed and the asbestos fibers are released in the air. Pain relief and symptoms are taken care of by removing fluid from the chest or the abdominal area. Use mint to make home-made natural tea, salads, or even just crush a few leaves and add to water with some lemon juice for a great healthy drink.
Water the oregano only when the soil is dry, as they are native to arid regions and don't like too much water.
Keep tarragon in a spot of the garden that enjoys full sun in the morning with dappled light in the afternoon.
Systemic non-enzymatic protein glycosylation, as reflected by levels of glycosylated hemoglobin, is a function of average blood glucose concentration over time.
Pancreatic alpha-amylase hydrolyzes complex starches to oligosaccharides in the lumen of the small intestine, while the membrane-bound intestinal alpha-glucosidases hydrolyze oligosaccharides, trisaccharides, and disaccharides to glucose and other monosaccharides in the brush border of the small intestine.
Because acarbose acts locally within the gastrointestinal tract, this low systemic bioavailability of parent compound is therapeutically desired.
In contrast, less than 2% of an oral dose was recovered in the urine as active (that is, parent compound and active metabolite) drug. There is little if any clinically significant interaction between Glucobay (Precose) and metformin. The placebo-subtracted treatment differences, which are summarized below, were statistically significant for both variables in all of these studies.
In the Glucobay (Precose)-treated patients on insulin, there was a statistically significant reduction in HbA1c at six months, and a trend for a reduction at one year.


Glucobay (Precose) is also contraindicated in patients with inflammatory bowel disease, colonic ulceration, partial intestinal obstruction or in patients predisposed to intestinal obstruction. Because Glucobay (Precose) given in combination with a sulfonylurea or insulin will cause a further lowering of blood glucose, it may increase the potential for hypoglycemia. Because Glucobay (Precose) given in combination with a sulfonylurea or insulin will cause a further lowering of blood sugar, it may increase the hypoglycemic potential of these agents. If elevated transaminases are observed, a reduction in dosage or withdrawal of therapy may be indicated, particularly if the elevations persist. When such drugs are administered to a patient receiving Glucobay (Precose), the patient should be closely observed for loss of blood glucose control. If hypoglycemia occurs, appropriate adjustments in the dosage of these agents should be made. In rabbits, reduced maternal body weight gain, probably the result of the pharmacodynamic activity of high doses of acarbose in the intestines, may have been responsible for a slight increase in the number of embryonic losses. This quality of pool therapy is quite beneficial in solving problems like arthritis, obesity, healing fractures etc. When we exercise on land, there is underdevelopment of some muscles because resistance happens only on one direction.
The exercises pertaining to water therapy can provide for trouble-free delivery and quicker weight loss after the birth.
Certain kinds of exercise like step ups, squats, etc; can be done easily in water rather than on land. The resistance offered and the buoyancy of water can actually reinforce muscle groups that are weak, and can be agonizing to exercise on land.
The carcinogenic or cancer causing asbestos mineral was finally regulated under Section 112 of the 1970 Clean Air Act. Lung cavity cancer or Pleural Mesothelioma is the most common type of malignant cancer often confused with viral pneumonia because both have similar symptoms. Asbestos can also happen in tap water where such water passes through cement pipes containing the substance. It is also important to give chives consistent watering in the growing season, to ensure high yields. Use it when making home-made pizza, mix it in with your pasta sauce or even try adding a bit to your morning's scrambled eggs. It can tolerate full afternoon sun in locations that don't get too hot, but it should be kept well-watered.
In diabetic patients, this enzyme inhibition results in a delayed glucose absorption and a lowering of postprandial hyperglycemia. Following oral dosing of healthy volunteers with 14C-labeled acarbose, peak plasma concentrations of radioactivity were attained 14–24 hours after dosing, while peak plasma concentrations of active drug were attained at approximately 1 hour.
The major metabolites have been identified as 4-methylpyrogallol derivatives (that is, sulfate, methyl, and glucuronide conjugates).
In addition, Glucobay (Precose) is contraindicated in patients who have chronic intestinal diseases associated with marked disorders of digestion or absorption and in patients who have conditions that may deteriorate as a result of increased gas formation in the intestine. Hypoglycemia does not occur in patients receiving metformin alone under usual circumstances of use, and no increased incidence of hypoglycemia was observed in patients when Glucobay (Precose) was added to metformin therapy. When such drugs are withdrawn from patients receiving Glucobay (Precose) in combination with sulfonylureas or insulin, patients should be observed closely for any evidence of hypoglycemia. Further studies were performed to separate direct carcinogenic effects of acarbose from indirect effects resulting from the carbohydrate malnutrition induced by the large doses of acarbose employed in the studies. Controlling high blood sugar helps prevent heart disease, strokes, kidney disease, blindness, and circulation problems, as well as sexual function problems (impotence). Water is the source of life and the physical properties of this most useful substance in the world-water is used to heal injuries, illnesses and disorders.
We can exercise easily and with more regularity in pool therapy; without feeling overexerted and pained during our workouts. Since pool therapy is in the form of low-impact exercises, they do not cause any harm on the joints, knees and ankles. Aquatic therapy also gives hydrostatic pressure which gives us sense of proprioception, which can give us sense of balance and protect us from falls. The law stated that employers of factories should provide good ventilation symptoms and safety measures so that they do not contract cancer mesothelioma or cancer asbestos. Asbestos manufacture though banned in the US since 1989, is present in buildings and products that existed before this time.
If the pleura is affected, the lung may have to be removed along with a part of the diaphragm, the process is known as pneumonectony,. Tarragon is a tasty spice for any dish with rice or chicken and can also add a refreshing, but not overpowering, taste to fish dishes. Commonly used in Italian cooking, basil combines wonderfully with anything that includes tomatoes and cheese. The delayed absorption of acarbose-related radioactivity reflects the absorption of metabolites that may be formed by either intestinal bacteria or intestinal enzymatic hydrolysis.
One metabolite (formed by cleavage of a glucose molecule from acarbose) also has alpha-glucosidase inhibitory activity. The plasma elimination half-life of acarbose activity is approximately 2 hours in healthy volunteers.
Oral glucose (dextrose), whose absorption is not inhibited by Glucobay (Precose), should be used instead of sucrose (cane sugar) in the treatment of mild to moderate hypoglycemia. The risk of hypoglycemia, its symptoms and treatment, and conditions that predispose to its development should be well understood by patients and responsible family members. In one study using Sprague-Dawley rats, acarbose was mixed with feed but carbohydrate deprivation was prevented by the addition of glucose to the diet. This metabolite, together with the parent compound, recovered from the urine, accounts for less than 2% of the total administered dose.
Sucrose, whose hydrolysis to glucose and fructose is inhibited by Glucobay (Precose), is unsuitable for the rapid correction of hypoglycemia. Because Glucobay (Precose) prevents the breakdown of table sugar, patients should have a readily available source of glucose (dextrose, D-glucose) to treat symptoms of low blood sugar when taking Glucobay (Precose) in combination with a sulfonylurea or insulin.
In a 26-month study of Sprague-Dawley rats, acarbose was administered by daily postprandial gavage so as to avoid the pharmacologic effects of the drug. Severe hypoglycemia may require the use of either intravenous glucose infusion or glucagon injection. In both of these studies, the increased incidence of renal tumors found in the original studies did not occur.
Take this medication by mouth, usually once daily with breakfast; or use as directed by your doctor.
Acarbose was also given in food and by postprandial gavage in two separate studies in Wistar rats. In two feeding studies of hamsters, with and without glucose supplementation, there was also no evidence of carcinogenicity.



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