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The purpose was to finally demonstrate whether or not good blood sugar control was really important to prevent the complications of diabetes. For you, a person with type 1 diabetes, lowering your A1C by 1 per cent means a 45 per cent less risk you will develop the chronic complications of diabetes! In this expert interview Professor Sir Alberti discusses why the epidemic rise in T2DM persists despite the availability of medicines.
Prof John Betteridge, London, discusses the evolution of diabetes therapy, the epidemic rise in diabetes, current and emerging diabetes therapies. The Cardio Diabetes Master Classes are dedicated to improve the clinical management of patients with diabetes and  cardiovascular disease. In GPRD data, current use of sulphonylureas only (with active or inactive metabolites) was associated with an increased risk of hypoglycaemic events, as compared with current use of metformin. Recent outcome trials of novel antidiabetic drugs shed new light on why diabetes patients develop heart disease. Out of 18 biomarkers, Lp-PLA2 and adiponectin were independently associated with a decreased risk for T2DM. In females with gestational diabetes, the future risk of developing type 2 diabetes depends on certain pregnancy-related and maternal factors that could be used for postnatal counselling.


EMPA-REG OUTCOME trial shows that empagliflozin reduces microvascular outcomes and progression of kidney disease in T2DM patients at high CV risk.
ADA 2016 In T2DM patients at high CV risk, liraglutide on top of standard therapy was associated with lower rates of CV events and mortality, compared with placebo in the LEADER outcome trial. ADA 2016 New empagliflozin data show that reduced risk for cardiovascular death was consistent across age groups in adults with type 2 diabetes.
ADA 2016 Two phase 3 studies of oral SGLT-2 inhibitor ertugliflozin met primary endpoints, showing significantly greater A1c reductions than placebo, alone or in combination with sitagliptin.
A1C chart on this page has A1C to BS conversion chart and calculator using the DCCT formula.
The hemoglobin A1C result is an important value for long-term glucose monitoring; about three months mean value of glucose level.
DCCT (The Diabetes Control and Complications Trial) Formula: Below is the a1c chart to show a relation between A1C and BS equivalent.
And indeed it is a€“ as you can see below, complications developed at a much lower rate in the intensively treated group compared to the conventional group. Early and optimal blood glucose control has long term benefits.Thata€™s why we believe so passionately in using the IT system, and why we want to help you find the best way for you to do this.


This A1C chart is based on the DCCT formula, a randomized clinical trial designed to compare intensive and conventional therapies and their relative effects on the development and progression of diabetic complications in patients with type 1.
Seven-point capillary blood-glucose profiles (pre-meal, post-meal, and bedtime) obtained in the DCCT were analyzed to define the relationship between HbA1c and BG. For example, kidney and eye disease may stay stable for years!At the end of the original DCCT trial, all the people in the conventional group changed to intensive therapy and their A1C lowered. Converting A1C to equivalent blood-glucose level (as shown by the glucometer) can be easier interpreting the result. He recommends DCCT's formula to convert A1C to BS than the formula by ADAG recommended by ADA. Goldstein, MD "Defining the Relationship Between Plasma Glucose and HbA1c, Analysis of glucose profiles and HbA1c in the Diabetes Control and Complications Trial," Diabetes Care 25:275-278, 2002. Now thata€™s commitment to a research study!Over time the A1C of the original intensive therapy and the former conventional therapy groups evened out at an average of 8%, but the benefits of intensive therapy remained a€“ much to everyonea€™s surprise.



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Comments

  1. Amirchik

    Not any laughing matter and many.

    27.06.2015

  2. 4e_LOVE_4ek_134

    Candy is also helpful storage, so if you can have a diet with low carbohydrates then high fat diet.

    27.06.2015