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A clinical trial at the Veterans Affairs Puget Sound Health Care System and the University of Washington will address new approaches to prevent the development of type 2 diabetes or slow its progression. The Restoring Insulin Secretion, or RISE, Study will examine the effects of three such medication regimens.  Each will be administered for 12 months. Thestudyis a nationwide program looking at the effects of various treatments to preserve insulin secretion and thereby prevent the development of diabetes or its progression early in the disease.
The study, sponsored by the National Institutes of Health, is currently recruiting patients.
More details are available at the National Institute of Health’s clinical trials website, identifier: NCT01779362. Diabetes explained is quite simple – it is a physical disorder where the cells in the body are not receiving glucose (the fuel the cells need for energy). Type I diabetes mellitus is an autoimmune disorder, usually developed in childhood, that is the result of the pancreas not producing enough insulin to meet the body’s needs.
Type II diabetes mellitus is the resistance some cells have to insulin, which prevents the glucose from being used. Gestational diabetes mellitus is similar to type II, but is caused by pregnancy and often disappears after pregnancy. Diabetes is the term people most use when referring to the condition known as diabetes mellitus.
A person with diabetes insipidus will also urinate a lot, but this is caused by a lack of the hormone vasopressin which acts to balance the body’s hydration level and has nothing to do with glucose or insulin. To explain diabetes mellitus, it is first important to know what insulin is and how it works. If the beta cells in the Islet of Langerhans do not produce enough insulin for the body’s needs, the person has what is called Type I diabetes (or juvenile diabetes).
People with Type II diabetes (or adult onset) have plenty of insulin in their system, but the cells do not recognize it.
Without glucose entering the cell, it starves and sends a message to the brain to eat carbohydrates (feed me Seymore).
In contrast, using this same analogy, if your house had Type I diabetes, you (glucose) would not have a key (insulin) to use at all. It is important to note that when a person is insulin resistant that not every cell in the body resists insulin.
If you, or anyone you care about, has any of these symptoms, please consult a physician right away.
When diabetes mellitus is untreated, the high levels of glucose can be very damaging to the body.


This FREE 9 Step Guide Will Help You Get Back on the Right Course to Better Health and Weight Loss.
Welcome to Live Fit I started Live Fit with the goal of helping 1 million people find and keep fitness and good health. I am starting this endeavor to make America fit using podcasts, articles, programs, education, and word of mouth. About This Site If you have struggled with diets in the past, and exercise is just not your thing, Live Fit can help you find the healthy habits and lifestyle that will allow you to Live Fit for Life. HbA1c is a term often used in relation to diabetes and this guide explains what HbA1c is, how it's used for diabetes diagnosis and how it differs from blood glucose levels. When glucose sticks to these molecules it forms a glycoslated haemoglobin molecule, also known as A1c and HbA1c. Due to the fact that red blood cells survive for 8-12 weeks before renewal, by measuring HbA1c, an average blood glucose reading can be returned. For people with diabetes, an HbA1c level of 6.5% is considered good control, although some people may prefer their numbers to be closer to that of non-diabetics. How often HbA1c levels should be taken depends on the person with diabetes and their history of control and treatment objections. There is little point in having HbA1c checked regularly if you are not making efforts to control your diabetes. Although HbA1c level alone does not predict diabetes complications, good control is known to lower the risk of complications. In well-controlled diabetes without a high level of glucose in the blood, a lower level of glycosylated haemoglobin will be returned. In the case of poor control, with more glucose, a higher level of glycosylated haemoglobin will be returned. Participants will be treated with medications normally used for people who have had diabetes for at least one year. The UW and VA diabetes research group in Seattle is one of three recruiting adult patients for the medication trial, along with the University of Chicago and Indiana University in Indianapolis. Steven Kahn, professor of medicine, Division of Metabolism, Endocrinology and Nutrition, at the University of Washington,  leads the Seattle clinical trial and is also chairs the national study.
To be eligible, patients must be between 20 and 65 years old, have prediabetes or self-reported type 2 diabetes for less than one year, and must not have taken any medications to treat diabetes in the past. The reason is either because the hormone insulin is not produced or the cells do not recognize this hormone. However, there are other meanings of this word and to be clear let’s look at the definitions.


When vasopressin (also called Anti Diuratic Hormone) is low, the body cannot hold water and a person will urinate until they are dehydrated. It then circulates through the blood stream and acts like a key to open a door in cells to let glucose in. They will have to monitor their blood sugar levels frequently, but with modern glucometers, this is not as invasive as it used to be.
These changes include, daily exercise, appropriate body composition (not being overweight), high consumption of produce (fruits and vegetables), a high fiber diet, lean meats and very limited sugar and saturated fats. The American Diabetes Association web site has statistics and much more information about this disorder. The study will enroll individuals who have prediabetes or have been recently diagnosed with diabetes, but who are not taking medications to treat the condition.
The expectation is that the use of these medications before diabetes has developed will preserve or enhance the body’s ability to produce insulin, the hormone that is crucial to maintain normal blood sugar levels.
To do this, the glucose is stored, first in muscle tissue, then in the liver, and finally any excess will be turned into triglycerides and stored as fat.
People with Type I diabetes will need to inject insulin several times a day to correspond with blood sugar levels that rise after eating. For example, most commonly, a person’s muscle cells are resistant to insulin, yet their fat cells are not.
The investigators aim to enroll 85 patients who will participate in the trial for 21 months. This means that the glucose in the blood will be accepted by the fat cells, which can take an unlimited amount of glucose to change into adipose (fat) tissue. If your house had Type II diabetes, your key would not fit into the lock – perhaps the neighbor kid put gum in it. To make this undesirable effect even worse, since the cells are not receiving energy the person is prompted to eat more.
Without being able to unlock the lock, you are not able to open the door and therefor, you (glucose) cannot go in.



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