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Tufts OCW material is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. Data are provided for the general population (red lines), and among men with high-risk and low-risk genetic profiles (black and grey lines, respectively), with and without family history (FH) of disease.
Listen SRP Diabetes Clinical Research Position Grants in DiabetologyDue to conflict of interest for the management group, the decision to award was taken by the Vice Dean, Board of Research at KI. On the basis of these estimates, the positive predictive value for a test that defines 60-year-old men at a high risk of being diagnosed with prostate cancer before age 65 if they have a family history and carry nine or more risk alleles is just under 20%. He decided, based on an external evaluation, to award the following four applicants; Ingrid Dahlman, Lisa Juntti-Berggren, Mikael Ryden and Sergiu-Bogdan Catrina. The intent of the grants are to enable the recipients (medical doctors with specialist certificate) to conduct research within diabetology on a half-time basis, while developing the clinical competence. For prostate cancer, I(t) is defined using age-specific Surveillance, Epidemiology and End Results (SEER) rates; for type 2 diabetes, I(t) is defined using incidence rates in the underlying Health Professionals Follow-up Study cohort. Ingrid Dahlman completed her MD at the Karolinska Institute in 1996, and in 1999 defended her thesis on genetic regulation of experimental autoimmne neuroinflammatory diseases in the laboratory of Professor Tomas Olsson. During her thesis work Ingrid became interested in human genetics and in 2001 she did a post doc in Professor John A Todd’s laboratory in Cambridge working on genetics of type 1 diabetes. Ingrid is employed as a Consultant in Endocronology and Diabetes at Ersta hospital and affiliated with the Lipid laboratory at the Department of Medicine, Huddinge.
In 2010 she attained a part-time senior research position financed by the Swedish Research council.


Ingrid’s current research is focused on the role of human adipose tissue in development of obesity associated insulin resistance.
More precisely, she applies global transcriptomic analyses and other pangenomic approaches to identify new mediators and regulators of insulin resistance in human fat cells.
Thereafter she did a residency at the Dept of Endocrinology, Karolinska University Hospital where she is now a senior consultant. She is specialized in Internal Medicine and Endocrinology and is Associate Professor in Endocrinology since 1997. In 2009 she got a 50% research position in Experimental Medicine from the Swedish Research Council. After moving to Stockholm she continued her research at The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, which is based on the findings  during her thesis work that serum from patients with type-1 diabetes increases voltage-gated Ca2+-channel activity and the subsequent increase in cytoplasmic free Ca2+ concentration, [Ca2+]i, is associated with apoptosis.
Not only is apoCIII of interest in type-1 diabetes it has also been shown to be increased in patients with type-2 diabetes and it is known that insulin resistance up-regulates the apoCIII gene. After a post-doctoral stay at the department of Medicine at Huddinge University Hospital, he became associate professor in 2002. The same year he was also appointed head of the Center for Clinical Metabolic Research in Diabetes within the Strategic Research program in Diabetes at Karolinska Institutet.
In July 2013, he was appointed professor of Clinical and Experimental Fat Tissue Research at the Department of Medicine, Karolinska, Huddinge. Prof Ryden’s research revolves around white adipose tissue, the most plastic organ in the human body.


Prof Ryden's research focuses on the patophysiological disturbances that promote a pernicious adipose tissue phenotype and combines cell and molecular biotechnologies in various cell culture systems with clinical studies. Catrina completed his MD in 1991 at the University of Medicine and Pharmacy “Carol Davila”, Bucharest Romania. He defended his first PhD in 2001 at the same university on the purification of a new active substance in pineal gland and his second PhD in 2005 at Karolinska Institute on the regulation of angiogenesis in diabetes and tumors in the laboratory of Professor Kerstin Brismar.
Catrina is a Consultant in Endocrinology since 2000 and became an Associate Professor in Endocrinology at Karolinska Institute at 2012. He is currently working at the Department of Endocrinology, Karolinska University Hospital in Solna. Catrinas research is focused on the pathogenic mechanisms contributing to the development of chronic complications in diabetes.
His research group has recently demonstrated that hyperglycemia modulates cellular mechanisms that are essential for angiogenesis and cell differentiation such as the HIF-mediated reaction to hypoxia. They are further exploring these signalling systems and their interaction both in vivo and in vitro to be able to design new therapeutic strategies and define biomarkers for chronic diabetes complications.



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