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The CHMP opinion concerns albiglutide proposed as a once-weekly treatment to improve glycemic control in adult patients with type 2 diabetes both as a monotherapy, when diet and exercise alone do not provide adequate glycemic control in patients for whom the use of metformin is considered inappropriate due to contraindications or intolerance, and as a add-on combination therapy, in combination with other glucose-lowering medicinal products including basal insulin, when these, together with diet and exercise, do not provide adequate glycemic control. The CHMP positive opinion is based on an evaluation of a comprehensive global program of studies involving over 5,000 patients. The program included eight Phase III trials evaluating albiglutide against commonly-used classes of type 2 diabetes treatment and involved patients at different stages of the disease, as well as those with renal impairment, for up to three years. A CHMP positive opinion is one of the last steps before marketing authorization is granted by the European Commission.
Albiglutide is currently undergoing review by other authorities, including the US Food and Drug Administration (FDA) and the US Prescription Drug User Fee Act (PDUFA) target date is 15 April 2014. Albiglutide is not approved for use anywhere in the world.
The Diabetes Media Foundation is a 501(c)(3) tax-exempt nonprofit media organization devoted to informing, educating, and generating community around living a healthy life with diabetes. Certain factors such as age, gender, heredity, family history and obesity play a role in deciding who is likely to develop diabetes. Carbohydrates are an important component of food we eat and in the body, they are broken down to give glucose. In some people, there is either a deficiency of insulin, or the insulin is unable to act as it should and this leads to the glucose remaining in the blood stream without absorption by the cells – the condition we know as diabetes.
Diabetic patients can eat beef, fish or chicken but the portions should be smaller than the size of one’s palm. There are certain foods which aggravate the risks of diabetes and there are also foods which help control diabetes. Enter your email address to subscribe to this blog and receive notifications of new posts by email. Links; This website may contain links to other websites, and this website’s owner is not responsible for the contents of such other websites. They’re both nutritious, energy-rich tubers and ancient, honored foods whose cultivation stretches back thousands of years.
They both originated in Central and South America and have since spread throughout the world. Potatoes (Solanum tuberosum) are in the Solanaceae family, related to tomatoes, peppers, and eggplant along with deadly nightshade.
Sweet potatoes (Ipomoea batatas) are in the Convolvulaceae family with flowering morning glory vines. There are about 4,000 known varieties of potatoes (with about 3,000 in the Andes alone) and about 5,000 varieties of sweet potatoes grown worldwide. For instance, fast-food restaurants demand a potato type (such as Russets) that has a particular size and shape, cuts well into French fries and holds together when deep-fried, but has a mealy, floury texture on the inside. Potatoes can also differ in their starch content and type, which affects not only how fast they’re digested, but how they act when cooked. Floury or “mealy” potatoes, which have a fluffy texture and are thus ideal for baking or mashing, are higher in starch, particularly amylose. Similarly, sweet potato types can vary in their texture, cooking properties, moisture, and sugar levels: White, yellow and purple-fleshed sweet potatoes are typically the dry type, while the orange-fleshed are moist. Most people in North America, western Europe, and Australia consume potatoes in some processed form — as French fries, tater tots, or potato chips. And in North America — especially in the Southern US — the phrase “sweet potato” is often followed by “pie”.
We typically slather spuds with other stuff, like butter or sour cream — and for our poutine-loving Canadian friends, gravy and cheese curds. In fact, partially due to their carbohydrate content, potatoes and sweet potatoes are highly satiating foods. In fact, in 2010, Chris Voigt, the executive director of the Washington State Potato Commission, tried a crazy experiment: 2 months of eating only potatoes. At first, he ate only when he felt hungry, and lost 12 lb in 3 weeks. To get enough calories, he then increased his intake to 20 potatoes a day… and he said he’d never felt so stuffed.
Despite apparently meeting his calorie needs, Voigt lost 9 more pounds throughout the rest of the experiment. Now of course, we don’t recommend the 20-potato-a-day diet. But Voigt’s results suggest — at least anecdotally — that in fact, starchy tubers are more satisfying and less fat-promoting than low-carb advocates might expect.
In part, this is because of the type of carbohydrate that occurs in potatoes and sweet potatoes. Here’s how 100 grams (about a cupped handful) of raw regular potatoes and orange sweet potatoes compare in terms of calories, fiber, and macronutrient content. As you can see above, sweet potatoes are indeed sweeter: They have 7 times the sugar content of regular potatoes. Most tubers contain some resistant starch — complex starch molecules that we can’t digest, which are then broken down by our gut bacteria in our large intestine. Potatoes also have a type of resistant starch known as retrograde starch: When you cook and then cool potatoes, the starch molecules shuffle themselves around into a different structure. To digest both potatoes and sweet potatoes, we have to break down and release the starch stored inside their cells. Because some of that starch is resistant starch, this breakdown takes time and effort, so although both potatoes and sweet potatoes are high in carbs, they don’t act the same way in our body as high-carb processed foods. Along with being “high carb”, eaters have often worried about the glycemic index (GI) and glycemic load (GL) of potatoes and sweet potatoes. Interestingly, an extract (known as caiapo) from white sweet potatoes is a promising type 2 diabetes treatment, and has been shown to improve many markers of metabolic disease. In fact, locals in Japan commonly ate white sweet potatoes raw as a treatment for anemia, hypertension, and diabetes.
Here’s a comparison of the blood glucose response to sweet potatoes, regular potatoes, regular potatoes with caiapo, and plain old glucose. Average glucose response relative to fasting blood glucose concentrations for foods containing 50 g of carbohydrate.
As you can see, white potatoes do often score higher on glycemic index and glycemic load tests than sweet potatoes.
As you can see in the chart below, sweet potatoes do not automatically have a “better” GI than white potatoes.
In the end, if you’re following PN guidelines, you’re probably including lean proteins, healthy fats, other vegetables and fruits, and naturally occurring fiber in your diet.
And it also means that most healthy and active people can eat potatoes and sweet potatoes just fine. Thus, even though both potatoes and sweet potatoes are “high in carbs”, not all carbs are created equal. Because of the type and nature of the carbohydrates they contain, both potatoes and sweet potatoes fill us up, give us energy, and leave us satiated for a long time.
As a bonus, sweet potatoes often satisfy sugar cravings, especially if they’re baked and caramelized. Purple-skinned, white-fleshed sweet potatoes in particular (often found in East Asian cuisines) tend to have a “cakey”, caramel taste that makes them perfect for managing the occasional sugar jones.
In general, potatoes and sweet potatoes are roughly similar in their vitamin and mineral content. But when it comes to vitamins and minerals, orange sweet potatoes are vitamin A superstars. Vitamin A occurs in retinol form in animal foods such as eggs, and in rich industrialized countries, many people can afford to eat these foods. However, in poorer countries, vitamin A deficiency is a common problem, causing blindness, other health problems, and over 600,000 deaths per year (mostly of young children or pregnant women).
Along with other colorful fruits and vegetables (such as leafy greens and squash), orange sweet potatoes contain high levels of the carotenoid form of vitamin A. Improving access to sweet potatoes and breeding vitamin-A-rich sweet potatoes are thus important nutritional strategies for preventing vitamin A deficiency.
Both potatoes and sweet potatoes contain antioxidants, substances that help control oxidative damage in the body. The phytochemicals (plant chemicals) in potatoes and sweet potatoes may also keep us healthy by regulating the immune system, fighting viruses and other pathogens, controlling inflammation, and inhibiting tumour growth. In fact, red-fleshed or purple-fleshed potatoes are comparable to Brussels sprouts, blueberries or spinach! Both potatoes and sweet potatoes also contain roughly the same amounts of L-tryptophan, the raw materials for serotonin, another “feel-good” neurotransmitter that makes us feel calm and happy. Antinutrients are substances that either interfere with nutrient absorption, or act as toxins in the body. Almost all plant foods contain antinutrients as natural defenses against pests, diseases, and environmental threats. In the end, both potatoes and sweet potatoes — like nearly all other plant foods — have some antinutrients.
Luckily, these occur in very low levels, and most of the time our bodies are perfectly able to process them. Potatoes contain proteins such as patatins and lectins which can be allergenic, particularly if potatoes are eaten raw. People who have other allergies (particularly latex allergies) are more susceptible to potato allergies, as are children. Potatoes also contain protease inhibitors, which may prompt an allergic reaction or interfere with the digestion of proteins. Potatoes contain salicylates, which can cause problems for those with a salicylate intolerance. Finally, the Solanaceae family of plants (which, again, contains tomatoes, peppers, and eggplant) may be somewhat inflammatory, and can produce reactions in susceptible people.


However, most of these are problems only for people with existing allergies, intolerances, and autoimmune disorders.
As you can guess by now, several factors determine whether potatoes and sweet potatoes (or, for that matter, most other foods) are more or less “healthy” or appropriate for your goals. Baking, boiling, or roasting potatoes and sweet potatoes is generally healthier than frying them. But if you see broccoli and perhaps a nice grass-fed steak, or wild-caught salmon, or some beans with those tubers… go for it! A little bit of healthy fat with sweet potatoes in particular will help you absorb their vitamin A. When eaten as whole, minimally processed plant foods, both potatoes and sweet potatoes’ carbohydrates are relatively slow-burning. So opt for the Nicoise salad over the instant mashed potato flakes, potato vodka, and sweet potato syrup. When eaten as whole, minimally processed foods, both potatoes and sweet potatoes are nutrient-dense.
Both potatoes and sweet potatoes contain vitamins and minerals, antioxidants and phytonutrients.
If you’re looking for a blast of carotenoid vitamin A, an orange-fleshed sweet potato is a clear winner. Sure, we’ve all indulged in a mashed potato fest at Thanksgiving or sweet potato fries at our local pub. But when we prepare both potatoes and sweet potatoes properly and eat them slowly as part of a normal, PN-friendly diet, we’ll usually find both to be satisfying and filling. Potatoes and sweet potatoes are relatively hardy crops that are easy to grow in most climates, although sweet potatoes prefer things a little warmer. Comparatively, potatoes and sweet potatoes are low-impact crops, requiring minimal water or additional processing.
Thus, aside from their nutrient content, potatoes and sweet potatoes promote “health” through food and social relationships. You might have guessed that while we rely a lot on clinical research, we also try to keep a sense of perspective.
We try not to get bogged down in the numbers, or look at single nutrients or foods in isolation. Having a baked potato with a meal or enjoying Grandma’s potato salad at a family reunion along with 7 other dishes is a lot different than being a fasted test subject who is fed exactly 200 grams of baked potato and nothing else.
So we work closely with our clients to see how scientific theories and findings manifest in real life — outside the lab.
Moreover, people can easily adapt this general recommendation to meet their individual goals.
We recommend that people experiment with various types of potatoes and sweet potatoes as well as cooking methods and cuisines.
If you suspect you may have a food intolerance, try keeping a food journal to see if you can associate your symptoms with a particular food. In it you’ll learn the best eating, exercise, and lifestyle strategies – unique and personal – for you. In development for the last 13 years, Invokana employs a “novel mechanism of action” to lower blood sugar in type 2 diabetics, Bloomgarden says. Invokana works by inhibiting sodium glucose co-transporter 2, a carrier that aids in the reabsorption of glucose into the bloodstream through the kidneys, which occurs during the process in which blood is filtered through the kidneys. Because Invokana is such a powerful diuretic, it can help lower a person’s systolic blood pressure, which made some clinical trial subjects feel dizzy and even faint in the first three months while taking the drug. Additionally, because Invokana blocks absorption of glucose, it could reduce a person’s weight. This method of reducing blood sugar by blocking glucose absorption in the kidneys proved safe and effective through nine clinical trials involving 10,285 participants, according to Janssen Pharmaceuticals. Even though the FDA voted 10 to five to approve Invokana, the jury is still partially out on the drug’s complete safety and the long-term effects of the new class of medication. Even though Invokana is a creative and apparently effective new way of reducing blood sugar, Bloomgarden says that metformin, or Glucophage is, and will most likely remain, the primary drug for treating type 2 diabetes.
The FDA said Invokana can be used in conjunction with other drugs, such as metformin, in patients as long as they do not have suffer from any kidney function impairment.
Patients won’t have to wait long to get their hands on Invokana if their doctor prescribes it for them. I am taking Invokana alone, as I am allergic to all othet medications for type 2 diabeties it works well keeping my sugars controlled, just have to drink a lot of water, but that is ok. Just started with Invokana about 2 weeks now (taking in addition to other type 2 meds and have seen a considerable drop in blood sugar readings. After I eat breakfast and take my blood sugar two hours after eating it is actually lower than when I take it first thing in the morning before I take my medications. I know that the price of this medication is high in cost but I really feel if it works for me which it is my life is more important to me than the money. Have been taking Invokana 100 mg for 4 weeks now and have just started to have cramps and diarrhea every day.
I have been on Invokana for 1 week now and have had the best results I have had in 2 years. I can’t tell how much of my positive result was caused by Invokana and how much to attribute to Weight Watchers.
One day you take on the world smelling like roses, but the next, despite continuous freshening up, you’re praying that the faint, yet putrid stench following you around isn’t coming from you — is it? Sometimes you can’t help but fall victim to bad body odor, and it’s not your fault or even a reflection of your personal hygiene — it’s your health. It’s like the foul odor of rotting garbage is seeping from between your legs, and you suspect it’s coming from the place you fear the most — your vagina. It’s reminiscent of freshly baked bread, but more yeasty, and it’s definitely not coming from an oven. Vaginal yeast is often kept in check by a delicate balance of the naturally occurring fungus candida and its bacteria counterpart, lactobacillus. Joking about “fishy” nether regions can be funny, but it can also be mortifying if it becomes reality.
It’s like a little fruit punch powder was added to your toilet bowl to create an unexpectedly sweet bathroom aroma. Diabetes indicates that your body isn’t producing enough insulin to regulate blood-glucose levels.
If you didn’t know better, you’d guess you hadn’t brushed, flossed or bothered to visit the dentist in a year. Sinusitis is a bacterial or viral infection that causes inflammation in sinus tissues, especially the hollow spaces in the bones that connect with the nose. Taking your toes out really puts you in a jam because, nine times out of 10, they fill the area with stinky feet stench. Related PostsCan Food Cause Body Odor?The Parents Are Horror-Stricken As Their Son Keeps Growing…. A final decision on marketing authorization is anticipated during the first quarter of 2014.
Regular exercise along with a modification in eating habits is what most doctors prescribe for people who have not yet developed diabetes in order to ensure they do not fall prey to the disease.
This glucose enters the blood and is circulated to all body parts where it has to be taken up by cells and tissues to meet their energy requirements. Foods that release a large amount of glucose at once therefore put a greater pressure on the body’s metabolic system and should be avoided. Basically, you should consume foods which are low in salt and contain more fiber. Fruits and vegetables are known to contain more fiber. The fact is that when properly planned and eaten in small quantities, sugar cannot cause severe or adverse effects and slight increases in blood sugar level can be brought down by exercise. A protein-rich diet is not the solution either because too much protein – especially animal protein – may induce insulin resistance, which influences diabetes.
When it comes to carbohydrate consumption, it is best to go with whole grain carbohydrates that are rich in fiber and digested slowly to ensure that blood sugar is maintained at steady levels. If you have medical concern or symptoms, or are considering use of herbs and supplements, please seek advice of qualified physician.
Some links may be advertisements of products from witch this website owner may make commission on sale. Others that their glycemic index (GI) is too high. As a result, the humble spud has taken a mashing in the recent low-carb years.
Not only that, his blood measures (such as cholesterol, triglycerides, and blood glucose) improved. Many processed foods are also vitamin A fortified, so few of us in North America suffer vitamin A deficiency. As little as a cupped handful of sweet potato a day can provide all the vitamin A that a small child needs. Potatoes also contain trace amounts of naturally occurring temazepam and diazepam (aka Valium) along with L-tyrosine (a precursor to dopamine, one of our “feel-good” neurotransmitters).
And, as mentioned, green potatoes are poisonous (so cut off the green bits or toss green potatoes altogether). Trypsin inhibitors can interfere with digestion by reducing the action of the digestive enzyme trypsin (which helps us digest proteins). This can be potatoes or sweet potatoes, but also a host of other delicious and nutritious choices: beans and lentils, fruit, whole minimally processed grains, etc. White potatoes may be a problem, if you have an underlying susceptibility (such as an autoimmune disease or other allergies, particularly a latex allergy).


Andean potato cultivars (Solanum tuberosum L.) as a source of antioxidant and mineral micronutrients.
Relationship between processing method and the glycemic indices of ten sweet potato (Ipomoea batatas) cultivars commonly consumed in Jamaica. Physical barriers to carotenoid bioaccessibility: Ultrastructure survey of chromoplast and cell wall morphology in nine carotenoid-containing fruits and vegetables. Study on chemical constituents and antioxidant activity of anthocyanins from purple sweet potato (Ipomoea batatas L.). Distribution of phenolic compounds and antioxidative activities in parts of sweet potato (Ipomoea batata L.) plants and in home processed roots. Cloning and characterization of an Orange gene that increases carotenoid accumulation and salt stress tolerance in transgenic sweetpotato cultures.
Red and purple coloured potatoes as a significant antioxidant source in human nutrition – a review. The introduction of orange-fleshed sweet potato in Mozambican diets: A marginal change to make a major difference. A food-based approach introducing orange-fleshed sweet potatoes increased vitamin A intake and serum retinol concentrations in young children in rural Mozambique. Improved metabolic control by Ipomoea batatas (Caiapo) is associated with increased adiponectin and decreased fibrinogen levels in type 2 diabetic subjects.
Efficacy of Ipomoea batatas (Caiapo) on diabetes control in Type 2 diabetic subjects treated with diet.
Some Canadian-grown potato cultivars contribute to a substantial content of essential dietary minerals. Comparison of the nutrient composition of four sweet potato varieties cultivated in Rwanda.
Historical collections reveal patterns of diffusion of sweet potato in Oceania obscured by modern plant movements and recombination. Multiple biological functions of sporamin related to stress tolerance in sweet potato (Ipomoea batatas Lam). Antioxidant activities, phenolic and b-carotene contents of sweet potato genotypes with varying ?esh colours. Relationship among the carotenoid content, dry matter content and sensory attributes of sweet potato.
Sweet potato and cassava can modify cholesterol profile in humans with moderately raised serum cholesterol levels. Microstructure and in vitro beta carotene bioaccessibility of heat processed orange fleshed sweet potato. Food and Drug Administration means diabetics have a significant new tool for treating the disease, as well as for losing weight and improving their overall health.
The excess glucose is then flushed out of the body, which is why Invokana also acts as a “potent diuretic,” Bloomgarden said. It also worked with about the same effectiveness as sitagliptin, or Januvia, which inhibits enzymes and increases pancreatic function, Ren added. For extended periods, however, reducing blood pressure in a population of patients with typically higher than normal blood pressure as a result of their diabetes is a positive side effect. According to Janssen Pharmaceuticals, clinical trials subjects taking the drug experienced a 3 percent weight loss compared to subjects taking a placebo. The most common side effects experienced were vaginal yeast infections and urinary tract infections, according to the company. A drug called dapagliflozin, from Bristol-Myers Squibb and AstraZeneca, that also works as a SGLT2 inhibitor, for instance, was rejected for approval by the FDA in 2012 because of concerns it increased rates of bladder and breast cancers in subjects. However, Invokana can be taken by those already taking metformin and other medications, according to the FDA. According to company spokesperson Christina Holden, Invokana is already being manufactured and field sales agents are already taking order from doctors. With the prescription she gave me a card to give to the pharmacy, now I get a year for free. I was taking Metformin only, but when it alone wasn’t controlling my glucose level my doctor put me on glimepiride. If you can’t quite sniff out the culprit, read on to see if medical intervention might be the cure. Greene suggests following up with a doctor because antibiotics may be needed to prevent infection. Instead, you trace this oddity to a source a little farther south and nearer your belt buckle. If the stench persists, and especially if it’s paired with discharge, seek a doctor’s help to get a stronger prescription — it might be a bacterial infection.
And we’re not talking a fleeting foul smell; we’re talking fully stocked fish market on a warm, busy day.
It’s most noticeable after sex or around menstruation and can be accompanied with discharge, itching and burning. This may not be the worst smelling situation, but — and it’s a big but — if the phenomenon persists, you’ll want to get a medical opinion.
Sweet urine is a side effect of your body expelling excess sugar that insulin fails to convert into energy. It causes horrific breath because of the mucus draining slowly down the back of your throat. But consult a physician if you develop a headache, stiff neck and swelling around the eyes or forehead or a change in vision.
Sometimes we are our own biggest critics, but that’s not always a bad thing, especially when it comes to hygiene. The uptake of glucose depends on the presence of sufficient quantity of insulin that helps mobilize the glucose in the appropriate manner. It is best to avoid highly refined carbohydrates like pasta, rice and white bread, candy, snacks and soda which are digested quickly and cause a spiking of blood glucose levels. No actual recommendations or any claims to use herbs, or any guarantees of their efficiency. So don’t eat the leaves or stems of any plant in this group, or potatoes that have gone green. Most common potato intolerance symptoms reported are eczema, stomach upset, hives and swelling, or — in rare situations — anaphylaxis. The Resistant Starch Report: An Australian update on health benefits, measurement and dietary intakes.
In Diversifying Food and Diets: Using Agricultural Biodiversity to Improve Nutrition and Health. Financial analysts are predicting that the drug will bring in more than $100 million in sales this year and top out at more than $660 million in annual sales by 2016.
I was switched to Invokana after I had a seriously bad reaction with Toujeo ugh it didn’t work for me.
Because I was getting dangerously low readings on the glimepiride, I decided to get a referral to an endocrinologist.
For example, it can result from wearing damp clothing, such as a bathing suit or sweaty gym shorts, for too long. In terms of feet, the smell occurs from sweaty feet fostering an ideal environment for bacteria and fungi to grow in your dark, warm shoes. Drink more water and instead of snacks, fried food and fatty meals, eat more low starch vegetables and nuts. Replace sugary cereal with high fiber cereal like Raisin Bran and change to rolled oats instead of instant oatmeal. The websiteis is for general information, reportage, background research and entertainment purposes only. Cutting up potatoes and sweet potatoes helps preserve their starchiness, while cooking them whole results in more sugariness. My doctor put me on Invokana and also gave me a card so I can get a year’s free supply. She also points out that a string may not be there, but a little digging can still reveal the culprit. Both websites are dedicated to educating and informing people with articles on powerful and concealed information from around the world.
Do not overeat; instead eat smaller portions to restrict the amount of glucose you release into the blood stream at a time. This website owner specifically disclaims responsibility for any consequence of using this website and its contains. I have spent the last 36+ years researching Bible, History, Alternative Health, Secret Societies, Symbolism and many other topics that are not reported by mainstream media. Now if I check right after I eat, I might see like 250~300 but if I eat and wait like 2 hours and check, its back down in the 150 range normally.
Looking to to me so far other than I’ve gotten dizzy a few times for a couple seconds and I checked, my sugars were not too low. Invokana has certainly helped and I will continue to take it until I no longer need it for control.



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Comments

  1. ZaraZa

    Progress has slowed?leading to under essential for.

    20.05.2016

  2. OGNI_BAKU

    See if that gets the weight to budge the.

    20.05.2016

  3. Buraxma_meni_Gulum

    Found that olive is very 2014 after her doctor told type 1 diabetes also known as LADA or Latent.

    20.05.2016