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Science, Technology and Medicine open access publisher.Publish, read and share novel research. Dominici M, Le Blanc K, Mueller I, Slaper-Cortenbach I, Marini F, Krause D: Minimal criteria for defining multipotent mesenchymal stromal cells.
A team of researchers from the University of Texas MD Anderson Cancer Center in Houston, have found that patients suffering from inflammatory breast cancer (IBC) can benefit from conjugating radiation treatments with simvastatin, a drug commonly used to treat high cholesterol and prevent cardiovascular disease. The study, published in the peer-reviewed journal Stem Cells Translational Medicine, examined simvastatin radiosensitization of different types of breast cancer cell lines in vitro to understand the therapeutic benefits of statins in controlling postmastectomy radiation (PMRT) in IBC patients.
Surviving breast cancer stem cells that develop resistance towards radiation and chemotherapy may be the underlying basis of IBC’s tendency to metastasize. A recent study from Danish scientists renewed the interest in the capacity of statins to affect breast cancer — “Our curiosity was piqued by the Denmark study and we also began looking at statins and found they seemed to improve survival in IBC patients.
From the total patients using statins, only 11% had a local recurrence of cancer when compared to 24% of the non-statin using group, demonstrating the compound potential to sensitize tumors to radiation therapy.
Statins have been used for a long time to treat hypercholesterolemia, and their capacity to improve disease outcomes in breast cancer patients has been known for a while.
Additional authors of this all-MD Anderson study entitled “Simvastatin radiosensitizes differentiated and stem-like breast cancer cell lines and is associated with improved local control in inflammatory breast cancer patients treated with postmastectomy radiation” include Lara Lacerda, Jay P.
Disclaimer:Radiation Therapy News is strictly a news and information website about the disease. While ticks can appear year-round in some climates, they’re especially prevalent in the summer and fall here in Ohio.

For more details about each species, the tick life cycle, and the diseases they carry (such as Lyme disease), check out this fact sheet from Ohio State University. Consider asking your vet about preventatives, especially if your pet is frequently outdoors. Your pets are unique, and Tipp City’s experienced staff are happy to point you in the right direction about any question, including how to deal with seasonal pests. Please Note:Your pet's health is our Primary Concern, so if you have an emergency please do not use this form and call us immediately at 937-667-8489.
Some characteristics and tests that may be considered as a quality control for the use of MSCs for cell therapy. As such, a compound that can effectively radiosensitize these resistant cells is of extreme importance to prevent cancer recurrence.
In this latest study, we took it a step further by examining the medical records of 519 women with stage III IBC who had undergone radiation treatment after mastectomy, comparing those who were taking simvastatin at the time of radiation with those who weren’t,” said Dr. Furthermore, their safe toxicity profile alongside low commercial cost make them the perfect candidates for accessible adjuvant use in radiotherapy.
Not every person or pet has a lifestyle that results in frequent exposure to ticks, but no matter your situation, it’s important to be educated about the threat they can pose, and how you can best take action to prevent them and the diseases they transmit.
Prescription topical medications like Parastar Plus kill ticks (as well as fleas and some other insects) for thirty days after application. Indicate a date and time that is convenient for you and we will contact you to confirm availability.

Wendy Woodward, IBC, MD Anderson, PMRT, radiation therapy, simvastatin, statins, stem cells.
This content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Some carry disease, so it’s important to familiarize yourself with the types you may encounter. Be sure you check for ticks not just on your dogs, but also on yourself and on children after wilderness adventures. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Common types are dog ticks, black-legged ticks (also known as deer ticks), and lone star ticks. There are also some natural ways to repel ticks, but consult with a vet before using substances like tea tree oil, which can be very toxic to cats and also cause problems for dogs if used improperly. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.
Your local health department can also assist you with this — check out the Ohio Department of Natural Resources website for more information about species common to Ohio, and to learn about submitting a captured tick for free identification.

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