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A cure for Type 1 diabetes has been possible by whole pancreas or islet cell transplantation for a number of years.
As with pancreatic transplants, successful stem cell transplants for diabetes is hampered by two other limiting factors. There are currently a variety of interesting scientific approaches to solving these problems.
As an example, one idea has been to take skin tissue from individual patients with diabetes, induce pleuripotent stem cells from these cells and then to create a supply of functioning beta cells from the stem cells.
A second and very interesting further stem cell approach to curing diabetes involves protecting stem cells from immune attack by developing them within a transplantable encapsulated device.
All the points discussed above must be very thoroughly researched and established by large-scale clinical trials before any doctor could safely recommend stem cell therapy to their patients.
In the past patients have been given a prescription called a diabetic diet with many foods banned.


First, foreign pancreas cells will be rejected by the recipient and necessitates the need for long-term anti-rejection drugs.
This may lead potentially and eventually to finding a stem cell therapy cure for Type 1 diabetes but we are a long way off this holy grail at the moment.
The technique could if successful provide an individual patient with a supply of their own genetically compatible transplantable pancreatic islet cells eliminating the requirement for anti-rejection drugs.
Human embryonic stem cells can be matured into functioning pancreatic beta cells within an encapsulated membrane.
Results proved that this system offers the necessary immunoprotection and proved that these devices can be stable, biocompatible, non degradable.
Scientists are actively pushing forward with stem cell research so as to try to find a way to overcome the main limitation of islet cell transplantation. Second, as Type 1 diabetes is an autoimmune disease where the patient?s own immune system attacked the pancreas in the first place, the destructive process will continue to cause harm to any newly transplanted cells unless measures are taken to protect them.


This can then be placed in the subcutaneous tissue of a patient with the aim of re-providing a source of insulin production previously lost during the development of diabetes. There is still the problem with this method of autoimmune attack from the patients own immune system but it does potentially solve the problem of rejection. The next stage is to get it working in humans but again there are very significant safety issues.
The very limited lack of donor pancreas material means that transplants are offered in only a very small minority of patients. A good choice to delve into progress in this area is to review the work of Professor Camillo Ricordi at the Diabetes Research Institute, University of Miami, Florida.



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Comments

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    18.10.2015

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    18.10.2015

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    18.10.2015

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    18.10.2015