Stem cell for type 2 diabetes treatment youtube,stem cell therapy for diabetes book,type 2 diabetes and eating disorder - How to DIY


The main symptoms of the diabetes mellitus type 2 are excessive thirst, excessive urination, weakness, fatigue and dry mucous membranes. One of the most common complications of diabetes mellitus are cardiovascular diseases, renal disease and retinal eye disease (retinopathy). For the treatment of diabetes mellitus type 2 the medicines, capable to reduce the level of blood sugar and insulin, are applied. Therefore, immunobiological methods of cell and regenerative therapies are increasingly used in the treatment of diabetes mellitus and its complications in the leading medical centers around the world. The Institute of Cell Therapy developed and clinically tested the method of treatment of diabetes mellitus, the 1st and 2nd type, by means of hematopoietic stem cells transplantation. Treatment of diabetes mellitus type 2 with the use of stem cells does not only increase the effectiveness of treatment by traditional means and methods, but sometimes enables to refuse completely from them. Do not waste your time and contact us, because the sooner you apply for this method, the more effective the treatment will be. Diabetes is an incurable condition in which the body cannot control blood sugar levels, because of problems with the hormone insulin. Under normal circumstances, the hormone insulin, which is made by your pancreas, carefully regulates how much glucose is in the blood. After a meal, the amount of glucose in your blood rises, which triggers the release of insulin. Type 1 diabetes is an autoimmune condition, and the immune system attacks the cells of the pancreas.
The exact mechanisms that lead to Type 2 diabetes are not fully understood, but an underlying genetic susceptibility is usually present.
Gestational Diabetes - During pregnancy, some women experience heightened blood sugar levels and can't produce enough insulin to absorb it all.
Maturity onset diabetes of the young (MODY) - Caused by a mutation in a single gene and is also very rare. If people living with Type 1 diabetes don't receive treatment they can develop very high blood sugar levels - hyperglycaemia - within days.
At the same time, the body starts breaking down fat for fuel to counter the low levels of sugar available to the cells. Those with Type 1 can also suffer a dangerous complication of treatment known as hypoglycaemia, which can cause a coma. If treatment doesn't effectively control high blood sugar levels, it leaves a person with diabetes more vulnerable to infections.
Type 2 diabetes tends to develop more gradually, which is one of the reasons why medical professionals think that so many cases go undiagnosed. In the long-term, diabetes raises the risk of many conditions, including peripheral vascular disease (when the arteries to the extremities are damaged by atherosclerosis) and peripheral nerve damage. Insulin is a peptide hormone secreted by the pancreas in response to increases in blood sugar, usually following a meal. After a meal, the amount of insulin secreted into the blood increases as blood sugar rises. If these nutrients are shuttled primarily into muscle cells, then the muscles grow and body fat is managed. Without enough insulin, you lose all of the anabolic effects, since there is not enough insulin to transport or store energy or nutrients. Continual elevation of insulin leads to large amounts of fat gain and risk for cardiovascular disease.
Type 2 diabetes is characterized by obesity (particularly central deposition adiposity, or fat around the middle and deep in the abdominal cavity), cardiovascular disease, systemic inflammation, and the poor ability of muscles to store nutrients, which leads to muscle wasting and fat storage as well as nutrients circulating in the blood.
Insulin resistance, and its associated metabolic syndrome, is a step along the road to type 2 diabetes. Due to the anabolic power of insulin, many over-fat individuals want to avoid insulin release. You need insulin, but the trick is to learn how to balance the anabolic effects in muscle tissue against the fat storage effects. Aim for a moderate carbohydrate consumption (~40% of diet) with an emphasis on fibrous carbohydrates like vegetables, fruits, legumes, and whole grains.
Investigate chromium and alpha lipoic acid, and make sure intake is adequate (but not excessive). While the glycemic and insulin indices of many foods are similar, some foods cause unexpected responses.
The purpose of nutrient timing is to maximize insulin’s anabolic effects while minimizing its other problematic side effects.
Some epidemiologic studies have found that breast-feeding is associated with a reduced risk for developing insulin-dependent diabetes.
Supplementing infant diets with gluten-containing foods before 3 months of age may encourage pancreatic dysfunction.
Asian and African populations who are physically active and follow diets low in fat and high in fibrous carbohydrates have lower incidence of diabetes than those living the “Western” lifestyle. The American Academy of Pediatrics stated that avoiding early exposure to cow’s milk may reduce the risk of developing antibodies to cow’s milk protein and type 1 diabetes. Alpha lipoic acid may increase glucose uptake in the cell by recruiting glucose transporters. Some people who are not obese by traditional measures are still at risk for insulin resistance anyway, particularly individuals with one or more close relatives who are diabetic, as well as many people of South Asian ethnic origin.
Many bodybuilders have experimented with injecting insulin in an attempt to maximize insulin’s anabolic effects. To learn more about making important improvements to your nutrition and exercise program, check out the following 5-day video courses. They’re probably better than 90% of the seminars we’ve ever attended on the subjects of exercise and nutrition (and probably better than a few we’ve given ourselves, too). In a healthy body, the insulin-producing beta cells of the pancreas are responsible for maintaining normal blood glucose levels. Right now, we imitate a diabetes cure by replacing insulin from the outside with injections. For a diabetes cure, then, we will need more than injected insulin; we will need beta cells, or a close imitation of them. So how can we replace beta cells without requiring immunosuppression to prevent transplant rejection?
Transdifferentiation is the process by which a cell is switched from one kind of tissue cell– say, a liver cell– to another kind– say, a beta cell. So, scientists have found that in order to turn a liver cell into a beta cell, we need to make the liver cell use beta cell transcription factors.
In the case of beta cells, many years of research have gone into determining that one of the most important beta cell transcription factors is a protein called PDX1. Further, cell therapy with virally transduced cells is still the Wild West, from a medical perspective.
I understand that transdifferentiation also conveniently circumvents the social-political-ethical issues surrounding stem cells. The Diabetes Media Foundation is a 501(c)(3) tax-exempt nonprofit media organization devoted to informing, educating, and generating community around living a healthy life with diabetes. Stem cell research holds promise for curing a wide range of illness such as heart disease, diabetes, and, cystic fibrosis.
Experiments have been conducted with other types of stem cells derived from bone marrow or umbilical cord blood; however, those cells are limited in the types of cells they can develop into.
However, these people can develop resistance to the donated cells over time, making them less effective.
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If you are watching the amount of sodium in your diet, you are probably interested in learning more about flavoring foods with herbs and spices. We don’t always know what causes cancer, but research shows that we can have a significant impact on reducing our risk with some simple lifestyle changes.
Treatments for cancer have traditionally been surgery, radiation therapy, and chemotherapy. Researchers have discovered a naturally occurring food preservative that kills cancer cells. Scientists have been searching for answers to the problem of cancer growth for decades by studying the mechanisms of cancer and looking for ways to induce cancerous cells to be reprogrammed to commit cellular death or apoptosis. EmaxHealth is for informational purposes and should not be considered medical advice, diagnosis or treatment recommendations. Stroke is a leading cause of adult impairment, with 20% of its survivors requiring institutionalized care and up to 30% of them being severely and permanently disabled. Stroke symptoms typically start suddenly, lasting from a few seconds to a couple of minutes, and in most cases do not progress further.
The only approved treatments of acute ischemic stroke involve restoring blood flow to the affected region by using thrombolytics or mechanical devices that physically remove clots.
What you are searching for is something that will bring the body back to the way it worked prior to the stroke. Swiss Medica Clinic has developed a set of protocols to address the patient's post stroke needs, including modifications to utilize many adaptive aids. We deliver simple, risk free, proven results, with the assistance of highly skilled professionals who understand the importance of personalized care. During this painless procedure, stem cells are delivered intravenously, after which they cross the blood brain barrier and copy neural stem cell activity, improving all the symptoms of a condition.
Swiss Medica Clinic has developed the Adult Autologous Stem Cell Therapy program to treat a variety of conditions, including stoke, multiple sclerosis, cerebral palsy, muscular dystrophy, amyotrophic lateral sclerosis and traumatic brain injury, etc. Avoidance of any allergic and immune reactions (patient's own cells suit chromosomal and genetic structure).


No oncological complications as adult stem cells in the comparison to embryonic cells are rather mature. The period of time between getting lipoaspirate and injection of the activated stem cells is only a few hours.
Adult stem cells are superior over embryonic stem cells, because they dona€™t require growth of several moths and come from patienta€™s own body, which is why there is no risk of side effects after the treatment. At Swiss Medica Clinic we deliver the treatment with proven results associated with the assistance of highly qualified professionals who realize the importance of personalized care, quality and confidence that guarantees the top standards of treatment. Swiss Medica Clinic is an excellent centre that offers stroke patients the most innovative therapies. For me, since I got back after my 2 weeks of having my treatment, within 2 days of being home speaking to friends and family around the world, they all noticed the difference in my speaking, cognitively and I was able to listen and integrate with conversations with my family at home. Patients with diabetes mellitus type 2 make about 90% of the total number of cases of diabetes mellitus. According to various sources, there are from 120 to 180 millions people, suffering from diabetes mellitus in the world, accounting for 2-3% of the world’s population. The incidence of diabetes has a family character, and your risk is 40%, if your close relatives suffered from this disease. In type 2 diabetes, the progressive increase of the blood glucose level and reduced ability to capture glucose by tissues occur, whereby the body utilizes free fatty acids and amino acids as the sources of energy, but the latter are necessary for the body for other purposes. Approximately 65% of deaths from diabetes mellitus are due to the myocardial infarction or stroke.
Due to the multiple life-threatening complications of the disease, diabetes mellitus is an extremely important medical and social problem.
For this purpose the cultures of xenogeneic cells from Langerhans islets were investigated, as well as bone marrow and cord blood stem cells.
The main purpose of such treatment is the prevention of complications of diabetes mellitus, normalization of the level of glycosylated hemoglobin in blood, reduction of the dose of insulin in diabetes type 1, and the normalization of blood glucose level in diabetes type 2. As an example, the data on the treatment of 25 patients with diabetes mellitus type 2, who participated in the clinical trials on the hematopoietic stem cell transplantation, performed by the Coordination Centre on Organs, Tissues and Cells Transplantation of the Ministry of Health of Ukraine on the basis of the Institute of Cell Therapy.
Stem cells restore sensitivity of cells and tissues to the action of insulin, significantly improve pancreatic function, which leads to the normalization of blood sugar level. The principle of treatment is based on the fact that stem cells are able to transform into ?-cells of the pancreas and promote the formation of stem cells of the patient. Clinical tests confirm that after stem cell treatment the positive tendency towards the increase of the level of insulin and decrease of the blood sugar. Insulin stimulates cells all over your body to absorb enough glucose from the blood to provide the energy, or fuel, that they need. It tends to affect people before the age of 40, and often follows a trigger such as a viral infection. In most cases it develops between the 14th and 26th week of pregnancy, known as the second trimester, and disappears after the baby is born. Because there is no insulin to drive the sugar from the blood into the cells, the kidneys try to remove the excess glucose.
This leads to toxic levels of acids building up in the blood - a life-threatening condition known as ketoacidosis. This occurs when blood sugar levels fall dangerously low as a result of taking too much insulin, or sometimes by skipping a meal. Over time it can also damage the small blood vessels and nerves throughout the body, including the smaller vessels at the back of the eye, which can result in blindness, and the kidneys, leading to kidney failure. If these nutrients are shuttled primarily into fat cells, then muscle mass is unchanged and body fat is increased. Since glucose is then poorly stored, people end up with both high circulating blood insulin and high circulating glucose. This can be done by increasing insulin sensitivity in the muscle while decreasing insulin sensitivity in the fat cells. In theory, it may help manage blood sugar, but trials using chromium have shown mixed results. Caffeinated coffee consumption impairs blood glucose homeostasis in response to high and low glycemic index meals in healthy men.
Dynamic strength training improves insulin sensitivity without altering plasma levels and gene expression of adipokines in subcutaneous adipose tissue in obese men. Association of insulin-dependent diabetes mellitus and celiac disease: a study based on serologic markers.
Six months of gluten-free diet do not influence autoantibody titers, but improve insulin secretion in subjects at high risk for type 1 diabetes. Dietary intakes and plasma concentrations of carotenoids and tocopherols in relation to glucose metabolism in subjects at high risk of type 2 diabetes: the Botnia Dietary Study.
Dietary patterns, insulin sensitivity, and adiposity in the multi-ethnic Insulin Resistance Atherosclerosis Study population. Antioxidant effects of chromium supplementation with type 2 diabetes mellitus and euglycemic subjects. Chromium treatment has no effect in patients with poorly controlled, insulin-treated type 2 diabetes in an obese Western population: a randomized, double-blind, placebo-controlled trial.
Exercise training and the antioxidant alpha-lipoic acid in the treatment of insulin resistance and type 2 diabetes. No effect of a diet with a reduced glycaemic index on satiety, energy intake and body weight in overweight and obese women. Dietary fats, fatty acids and insulin resistance: short review of a multifaceted connection. A low-fat, vegan diet improves glycemic control and cardiovascular risk factors in a randomized clinical trial in individuals with type 2 diabetes. The effects of epigallocateghin-3-gallate on thermogenesis and fat oxidation in obese men: a pilot study.
Effects of 3-week consumption of green tea extracts on whole-body metabolism during cycling exercise in endurance-trained men. In type 1 diabetes, however, these beta cells die as a result of an autoimmune attack, and in type 2 diabetes, beta cells can become overtaxed and begin to die off. Many researchers around the world are working on different approaches to allow us to produce steady, sustainable supplies of insulin-producing cells. Sarah Ferber runs a lab in Sheba Medical Center near Tel Aviv, and has founded the company Orgenesis in order to turn a dozen years worth of her research into a cure for insulin-dependent diabetes, whether type 1 or type 2. Ferber and Orgenesis are currently working towards developing the technology to extract liver cells from a patient with a biopsy, expand the liver cells in culture in the lab, and then turn the liver cells into functional beta cells.
This process is similar to taking a stem cell and turning it into any kind of tissue cell (ViaCyte is trying to make beta cells from stem cells in this manner), but instead of starting from a stem cell that can by its nature turn into many kinds of cells, transdifferentiation starts from a cell that is already committed to being a certain kind of cell.
Ferber must tell the liver cell, “Stop acting like a liver cell, and start acting like a beta cell.” For many years, scientists have been studying the question of what makes a certain kind of cell do what it does, and for decades research has been building that shows that certain proteins within cells, called transcription factors, are responsible for binding to DNA and turning genes on and off within cells.
In the last ten years, there has been a renaissance in this sort of transdifferentiation by replacing transcription factors, and, luckily for diabetics, beta cells are one of the big areas of focus in this field. This is not the only important factor, and in fact transcription factors are not binary, but maybe what makes beta cells beta-cell-like is the particular mix and balance of all sorts of transcription factors, but PDX1 is a very good start, and might be enough to tip the balance of the cell.
Ferber takes liver cells from a patient, grows them in a dish, and then adds a viral vector with the gene for PDX1 to the liver cells. Ferber is now progressing towards the point of being able to run human clinical trials, one step at a time. Autologous cells may get around the problem of transplant rejection, but not necessarily the problem of autoimmunity for type 1 diabetics. There are a handful of FDA approved cell therapies, but no approved gene therapy products outside of clinical trials to date, and no approved transdifferentiated cell therapies. I was vaguely aware of this research, and I much appreciate the thorough explanation and profile. Stem cells are pluripotent cells that possess the ability to develop into any type of cell in the body. The newer approach involves reprogramming mature cells, typically from the skin, without the need to destroy embryos.
Stem-cell derived platelets could overcome that problem because they could be derived from a patient's own cells.
However in 1985, hyperthermia therapy, a natural non-invasive treatment which allows the generation of heat to a specific area to kill tumor cells was approved for clinical use.
Nisin, a food preservative used to stop bacterial growth in dairy products, just might have potential as a cancer treatment.
A mere 3 months after delivering a seemingly healthy baby girl that they named, Layla, Lisa and Ashleigh Richards got the worst imaginable news.
They say the treatment, having successfully cured mice of the disorder for six months and counting, is moving on to primate trials before testing is done on humans. However, the use of thrombolytics is limited due to the therapeutic window of 3-6 hours post onset of stroke symptoms, so that only a small fraction of stroke patients receives this therapy, thus effective prevention remains the best treatment for reducing the burden of stroke. You are already aware of the side effects and the ailments that a stroke can cause to the human brain and dysfunctions of normal bodily functions.
However, there was no considerable therapy which could promote recovery other than physical, occupational, and speech therapy. Now the re-growth of brain cells and improvements of neurological function has been documented.
The patient's own stem cells are harvested from abdominal fat or bone marrow, activated and put back into the body.
This is the only stem cell treatment that is free of side effects and rejection, because the cells come from patienta€™s own body. After reaching the organism, they start replacing the damaged cells and the restoration of the brain begins.
Nowadays the re-growth of brain cells and improvements of neurological function has been documented.


We use advanced technology to activate dormant cells (adipose mesenchymal stem cells) to differentiate into the cells we need, and then they replace the damaged cells. The likelihood of the development of diabetes mellitus is 50%, if the father had diabetes, and 35%, if the mother was sick.
Chronic hyperglycemia leads to the increase of the osmotic pressure of blood and damage of the vessel wall (angiopathy).
However, the currently known methods of correction of metabolic disturbances in diabetes mellitus do not provide the desired effect and do not prevent disability.
American scientists have shown a positive effect of the umbilical cord blood infusions in patients with diabetes mellitus, enabling to reduce the dose of insulin in such patients. The principle of treatment is based on the fact that the hematopoietic cells are able to transform into ?-cells in the pancreas as well as to stimulate the formation of these cells from the patient’s own stem cells (such cells are present in pancreatic ducts). The diagrams clearly show that within 3 months after transplantation the level of glucose and glucosylated hemoglobin reduced almost to normal values and remain stable for 1 year.
If you suffer from diabetes mellitus type 2, we invite you to our clinic for a high quality and effective treatment of this disease. This can result not only the restoration of the normal level of sugar in blood but also anables to prevent the complications of diabetes mellitus, such as the damage of blood vessels of the retina, kidney, heart and legs. This therapy also causes the healing of the ulcers and tissue defects of the foot, improves microcirculation and reduces the incidence of diabetic angiopathy.
It can also be produced by carbohydrates such as potatoes, pasta or bread when they are digested and broken down.
In Type 2 diabetes, either the pancreas cells do not make enough insulin, or the body's cells do not react properly to it. The condition is then triggered by lifestyle factors - such as obesity - and it usually appears in people over the age of 40. The brain requires a constant supply of glucose from the blood otherwise it can't function properly. Once insulin is in the blood, it shuttles glucose (carbohydrates), amino acids, and blood fats into the cells of the body. A crucial part of a diabetes cure, therefore, will be replacing any lost beta cells with a source of insulin for the body.
Some are starting with embryonic stem cell lines, some are starting with gut cells, some are starting with pigs, and Dr.
Like many researchers, she sees the benefits of islet transplantation: patients given islet cells, which include beta cells, from donor pancreases can produce insulin in response to glucose, just like non-diabetics. Ferber’s approach is to use autologous liver cells that are transdifferentiated in vitro into beta cells.  In other words, Dr. The first two steps are straightforward, and the third step is one they are making good progress on using science’s growing understanding of transdifferentiation.
A liver cell acts like a liver cell because it has liver transcription factors, and those keep liver genes turned on.  A beta cell acts like a beta cell because it has beta cell transcription factors and not liver transcription factors.
A number of groups are working to transdifferentiate alpha cells and gut cells, as those are close to beta cells on the developmental tree.
The vector enters the cells, and forces the cell to start making the PDX1 protein from the gene. Two of the researchers who developed the process shared a Nobel Prize this year for the work. When combined with very low dose radiation, proponents of this non-traditional treatment claim a success rate of 85-92% remission.
They were told their infant daughter was suffering from acute lymphoblastic leukemia (ALL), a type of cancer in which the bone marrow makes too many immature lymphocytes, a type of white blood cell (WBC) involved in moderating the immune system. Ischemic strokes are those that are caused by interruption of blood supply, while hemorrhagic strokes are the ones which result from rupture of a blood vessel or an abnormal vascular structure. Unlike many other clinics, we process our multiple applications quickly, and there is no need to wait weeks to get a treatment. Stem cell treatment acts as a form of medical time machine, reversing the damage that has already been made. This quantity of the restored plain cells not only covers daily losses, but also exceeds them by thousands of times, renewing almost 15 a€“ 20 years worth. In diabetic micro-and macroangiopathy the vascular permeability is disrupted, vessel fragility is increased and the tendency to thrombosis and atherosclerosis occurs. Also it was shown that the use of endothelial progenitor cells, capable to form new blood vessels, promotes neangiogenesis in patients with obliterative vascular disease of the lower extremities on the background of diabetes mellitus type 2.
Furthermore, hematopoietic cells restore the endothelial cells of blood vessels, that are damaged by glycosylated hemoglobin in diabetes mellitus.
In addition, in these patients the indices of fat metabolism also were normalized, the atherogenic index decreased, the biochemical parameters of liver function improved. Also the recovery of “red blood” occurs, namely the increase of the level of hemoglobin and number of red blood cells. Keep in mind that a low glycemic diet can result in better fasted insulin and glucose, but results have been mixed. However, she also sees significant drawbacks: islet supplies are limited, and, as with other organ transplants, patients must take immunosuppressive drugs to prevent the destruction of the transplanted beta cells. Ferber wants to take a patient’s own liver cells, turn them into beta cells in the lab, and then put them back in the patient just like an islet cell transplant.
PDX1 then begins to turn off liver genes and transcription factors, and to turn on beta cell genes.
Ferber has early evidence in mice that the trandifferentiated cells, though beta-cell-like, are sufficiently different from actual beta cells that they seem to slip by the immune system. Hyperthermia is internationally known as the fourth treatment in cancer therapy and while relatively new to the U.S is well known and widely used in other countries like Japan, Germany, Switzerland, Denmark, France, Italy, and China.
ALL is the most common type of cancer in children and in aggressive forms has about a 1 in 4 survival rate. The research was found by stem cell scientist Douglas Melton and a team of Harvard researchers and published in the journal Cell Thursday.
The procedure is safe and proven to activate cells around the suffering brain tissue to catalyze rapid healing and to improve brain function.
This causes symptoms of a disease to improve and the whole body and all of the organs become healthier and rejuvenated, because the new and active cells replace the old and damaged ones. Renal disease in diabetes (diabetic nephropathy) is one of the factors of the development of chronic renal failure. It is noteworthy, that the transplantation of the large doses of hematopoietic stem cells eliminates the autoimmune component of the disease in patients with diabetes mellitus type 1 and 2.
Because the starting cells are the patient’s own cells, important protein markers on the cells would “match” what the patient’s immune system expects, and the cells would in theory not induce an immune reaction like an organ transplant would. Stem cell treatment improves bending and straightening of the joints and adding more agility in fingers. Whatever the starting material, the strategy is similar: take the genes for beta cell transcription factors, put them into the target cell, and force the target cell to make the beta cell transcription factors.
Ferber has been able to take patient cells, turn them into insulin producing cells with PDX1, and then put the transdifferentiated cells into mice, curing the mice of diabetes.
The company plans to begin the process for regulatory approval as early as December 14, 2012. Individuals with certain types of leukemia, anemia, and other blood disorders require repeat infusions of platelets to avoid hemorrhaging. If approval is granted, Advanced Cell Technology will embark on the first human trial involving stem cells created by reprogramming adult cells back to an embryonic-like state. That was really exciting.” Researchers grew billions of insulin-secreting, or beta, cells using stem cells from humans. Violation of the microvasculature and secondary immunodeficiency cause the infections of the soft tissues of the foot, nonhealing wounds, trophic ulcers. While you will be able to view the content of this page in your current browser, you will not be able to get the full visual experience. They then injected the cells into diabetic mice, and observed their blood sugar levels, which remained at healthy levels after six months. These patients develop necrotic processes of the ulcerated foot, lesions of bones and joints. Please consider upgrading your browser software or enabling style sheets (CSS) if you are able to do so. Melton said he was driven to find a “cure for diabetes” ever since his children developed type 1 at an early age. The diabetic foot often leads to the necessity of the limb amputation in diabetic patients.
The beta cells that he and his researchers grew from stem cells functioned like normal ones, and were not attacked by the mice’s immune systems, a common problem with treatments like the ones used by Melton and his team. Type 1 diabetes is an autoimmune disease that affects those who develop it for life — more than 34 million worldwide. People with type 1 diabetes currently rely on daily injections of insulin to control their blood sugar. However, the shots are much less accurate than the body’s own metabolism, and often lead to nerve damage, loss of limbs and blindness. Researchers are now testing the method on other animals, and will soon test it on primates to determine its viability in humans.



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