Statin drugs linked to diabetes risk,natural remedies for diabetes management 9th,why is type 2 diabetes caused by diet soda - 2016 Feature


CONTROVERSIAL heart drug statins have been linked to almost twenty thousand reports of side effects and 227 deaths.
Could statins, the cholesterol-lowering drugs taken by more than 60 million Americans and now being recommended for use in children as young as 8 years old, be doing more harm than good to millions of patients? A man in France continues to puzzle scientists nearly a decade after he was found to be living with just 10 percent of a typical human brain.
At the time of the original study, the patient was a 44-year-old man who had been experiencing weakness in his left leg. Despite the reduced brain matter, the man lived a relatively normal life; he was a married civil servant with two kids. Lovastatin, a compound isolated from Aspergillus terreus, was the first statin to be marketed. Statins, also known as HMG-CoA reductase inhibitors, are a class of lipid-lowering medications that inhibit the enzyme HMG-CoA reductase which plays a central role in the production of cholesterol. Clinical practice guidelines generally recommend people to try "lifestyle modification", including a cholesterol-lowering diet and physical exercise, before statin use.
Most evidence suggests that statins are effective in preventing heart disease in those with high cholesterol, but no history of heart disease.
Rare reactions include myopathies such as myositis (inflammation of the muscles) or even rhabdomyolysis (destruction of muscle cells), which can in turn result in life-threatening kidney injury. The FDA notified healthcare professionals of updates to the prescribing information concerning interactions between protease inhibitors and certain statin drugs. The HMG-CoA reductase pathway, which is blocked by statins via inhibiting the rate limiting enzyme HMG-CoA reductase. Statins act by competitively inhibiting HMG-CoA reductase, the first committed enzyme of the mevalonate pathway.
By inhibiting HMG-CoA reductase, statins block the pathway for synthesizing cholesterol in the liver.
In rabbits, liver cells sense the reduced levels of liver cholesterol and seek to compensate by synthesizing LDL receptors to draw cholesterol out of the circulation.[95] This is accomplished via proteases that cleave membrane-bound sterol regulatory element binding proteins, which then migrate to the nucleus and bind to the sterol response elements. As noted above, statins exhibit action beyond lipid-lowering activity in the prevention of atherosclerosis. THE risk of developing cloudy lenses in the eyes (cataracts) may be linked to the use of cholesterol-lowering drugs known as statins, according to a new study.The finding builds on a growing body of research on the long-term risks of statin drugs.
New research shows an increased risk of clouding of the eye lens in people who take statins. His case was originally published in The Lancet journal in 2007 but was presented last month at the Association for the Scientific Study of Consciousness conference in Buenos Aires.


High cholesterol levels have been associated with cardiovascular disease (CVD).[1] Statins have been found to reduce cardiovascular disease and mortality in those who are at high risk. In this latter group, statin assignment was not automatic, but was recommended to occur only after a clinician-patient risk discussion with shared decision making where other risk factors and lifestyle are addressed, the potential for benefit from a statin is weighed against the potential for adverse effects or drug drug interactions and informed patient preference is elicited. However, the risk was over 10-fold greater if cerivastatin was used, or if the standard statins (atorvastatin, fluvastatin, lovastatin, pravastatin, or simvastatin) were combined with fibrate (fenofibrate or gemfibrozil) treatment. Protease inhibitors and statins taken together may increase the blood levels of statins and increase the risk for muscle injury (myopathy).
Because statins are similar in structure to HMG-CoA on a molecular level, they will fit into the enzyme's active site and compete with the native substrate (HMG-CoA).
This is significant because most circulating cholesterol comes from internal manufacture rather than the diet. The sterol response elements then facilitate increased transcription of various other proteins, most notably, LDL receptor.
This competition reduces the rate by which HMG-CoA reductase is able to produce mevalonate, the next molecule in the cascade that eventually produces cholesterol.
When the liver can no longer produce cholesterol, levels of cholesterol in the blood will fall. The LDL receptor is transported to the liver cell membrane and binds to passing LDL and VLDL particles (colloquially, "bad cholesterol"), mediating their uptake into the liver, where the cholesterol is reprocessed into bile salts and other byproducts. There are no definitive statistics on how many South Africans are taking statins, but the number is known to be in the hundreds of thousands. The data uncovered is very alarming and shows the risks of these drugs have been downplayed. Additional factors that could be used were an LDL-C a‰? 160 or a very high lifetime risk.[21] However, critics such as Steven E.
A variety of natural statins are produced by Penicillium and Aspergillus fungi as secondary metabolites. Cholesterol synthesis appears to occur mostly at night,[91] so statins with short half-lives are usually taken at night to maximize their effect.
The bile salts are secreted into the duodenum during digestion of fats and are subsequently reabsorbed later in the jejunum and ileum. The drugs are especially recommended for people with diabetes or a history of cardiovascular problems.Belgian medical specialist Dr Geert Verhelst, who visited South Africa on a lecture tour recently, said that was ironic, as the drugs are shown to increase the risk of type 2 diabetes. This new research challenges the medical convention that lowering your cholesterol is always a good thing.“If you deprive cholesterol from the brain, then you directly affect how smart you are and how well you remember things,” says Yeon-Kyun Shin, the biophysics professor behind the study. Although the risk was small, it contributed to the global pandemic of type 2 diabetes.Statins are also shown to have a host of other negative side effects, the most common of which is muscle myalgia or weakness (severe enough for one product to be withdrawn from the market).


The drugs have also been linked to kidney and liver problems, memory loss and dementias such as Alzheimera€™s, neurological problems such as Parkinsona€™s, and reduced sex drive.When it comes to cataracts, researchers have looked at the link with statins before with mixed results.
Low-density lipoprotein (LDL) - often referred to as bad cholesterol - is cholesterol in the bloodstream from the liver on the way to cells in the body. High-density lipoprotein (HDL) - so-called good cholesterol - is cholesterol being removed from cells lining the blood vessels. It goes back to if there is a good reason for you to be on that statin, it outweighs the risk of a mild increase in risk of cataract," Dr Cioffi, who was not involved in the new study, says.He says the treatments for cataracts have evolved over time.
Too much LDL going to cells and not enough being removed can lead to cholesterol deposits and hardening of the arteries.“If you have too much cholesterol, your internal machinery is not going to be able to take away enough cholesterol from the cells,” said Shin. But if you try to lower the cholesterol by taking medicine that is attacking the machinery of cholesterol synthesis in the liver, that medicine goes to the brain too. And then it reduces the synthesis of cholesterol which is necessary in the brain,” said Shin.In his experiments, Shin tested the activity of the neurotransmitter-release machinery from brain cells without cholesterol present and measured how well the machinery functioned. Cholesterol increased protein function by five times.“Our study shows there is a direct link between cholesterol and the neurotransmitter release,” said Shin.
Cholesterol changes the shape of the protein to stimulate thinking and memory.”Shin's findings reinforce another new study, which found that men with a combination of low cholesterol and depression are seven times more likely to die prematurely from suicide, accidents and other unnatural causes than men with only depression. Scientists who followed nearly 4,500 Vietnam veterans over a 15-year period say the disturbing findings may be due to low blood cholesterol reducing levels of the brain's feel-good chemical messenger, serotonin. Low serotonin is linked to depression, anger, sleep loss and other problems, says Dr Joseph Boscarino, of the American Geisinger research institute, who did the research. In fact, there is a significant body of evidence to show that low cholesterol may be as dangerous as high cholesterol.These reputable studies show how people with markedly low levels of cholesterol are more likely to die from a variety of causes, including strokes, certain cancers, liver disease, lung disease and suicide. The deaths from these other causes mount so quickly that the mortality rate for those with low cholesterol equals the rate for people with very high cholesterol.Another report claims that women on low-cholesterol diets may face infertility problems.
This small study of 300 patients by the Toronto Infertility Clinic says that cholesterol is essential for creating the sex hormones oestrogen and testosterone.
Even more worrying, studies of older people have found that those on low- cholesterol diets have a much higher rate of stroke, possibly because cholesterol has a protective effect in mature brain linings. But the link between low cholesterol, decreased serotonin and dangerous behavior is particularly strong and disturbing.
See your chiropractor today to find out how chiropractic care can help you begin to extricate yourself from the cycle of dependence on dangerous patent drugs.



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