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Osteogenesis imperfecta is a condition causing extremely fragile bones. Causes Osteogenesis imperfecta (OI) is a congenital disease, meaning it is present at birth. You must have JavaScript enabled in your browser to utilize the functionality of this website.
It is frequently caused by defect in the gene that produces type 1 collagen, an important building block of bone. HD Wallpaper and background images in the Pokemon ranger club tagged: pokemon ranger go rock squad.
The severity of OI depends on the specific gene defect. OI is an autosomal dominant disease.
A physical examination may show that the whites of their eyes have a blue tint. A definitive diagnosis may be made using a skin punch biopsy.


Family members may be given a DNA blood test. If there is a family history of OI, chorionic villus sampling may be done during pregnancy to determine if the baby has the condition. However, specific therapies can reduce the pain and complications associated with OI. Bisphosphonates are drugs that have been used to treat osteoporosis.
They have proven to be very valuable in the treatment of OI symptoms, particularly in children. They have been shown to greatly reduce bone pain and fracture rate (especially in the bones of the spine). Low impact exercises such as swimming keep muscles strong and help maintain strong bones.
Such exercise can be very beneficial for persons with OI and should be encouraged. In more severe cases, surgery to place metal rods into the long bones of the legs may be considered to strength the bone and reduce the risk of fracture.
Bracing can also be helpful for some people. Reconstructive surgery may be needed to correct any deformities.


Such treatment is important because deformities (such as bowed legs or a spinal problem) can significantly affect a person's ability to move or walk. Regardless of treatment, fractures will occur. Time in a cast should be limited since bone loss (disuse osteoporosis) may occur when you do not use a part of your body for a period of time. Many children with OI develop body image problems as they enter their teenage years.
Persons with this type have many fractures starting very early in life and can have severe bone deformities. Many become wheelchair bound and usually have a somewhat shortened life expectancy. Type IV, or moderately severe OI, is similar to type I, although persons with type IV often need braces or crutches to walk.



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