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The symptoms of diabetes, on skin are mostly curable, especially, if they are detected early. Due to diabetes, the smaller blood vessels supplying blood and oxygen to the skin get damaged. The diabetes leads to damaging of the blood vessels and this damage is visible in the form of different skin conditions.
Other than diabetic dermopathy, damage in blood vessels can also cause Necrobiosis lipoidica diabeticorum or NLD, where large and shiny scaly patches develop over the skin. The diabetics have high sugar level in their blood, providing a perfect medium for the growth of fungus and other pathogens. This fungus mostly develops in moist and warm areas regions of the skin, like, around the fingernails, between toes, in armpits, in groin area, under foreskin of male genitalia, and also in corners of the mouth. Other fungal infections that may be found in the skin of diabetic patients, include, athlete’s foot, jock itch and ring worm.
Bacterial infections are also very prominent, on the skin of diabetic patients, due to high blood sugar levels.
The most common bacterial infections found in the skin of diabetic patients, include, boils, infection of glands present in the eyelids, inflammation of a certain region of skin and tissues below it also called as carbuncles, folliculitis (infection in the hair follicles) and inflammation around the nails. Blisters are not a regular sight in the diabetic patients, but, some patients may develop blisters in their forearms, feet, toes, hands and fingers. This condition is mainly found in the patients suffering from type 1 diabetes and can be controlled by normalizing blood sugar levels.
This condition of the skin is mainly found, in the males of younger age group, suffering from type 1 diabetes.
Due to high glucose levels, the fluid from the skin cells evaporates, leaving the skin dry. Diabetic patients need to take special care of their skin, and keep on sanitizing and moisturizing it, to prevent it from drying. Atherosclerosis is the thickening of arteries, and a common occurrence in diabetic patients. O Diabetes e uma doenca conhecida como assassina silencioso pois muitas vezes os sintomas passam despercebido, e a pessoa descobre quando ja esta num grau avancado da doenca.
Por isso a melhor maneira de descobrir se voce tem diabetes, e fazer um exame de sangue, a glicemia em jejum. Hoje vou deixar aqui os sintomas mais comuns da doenca, se voce tiver mais de 1, procure ja um medico endocrinologista.
Se voce precisar urinar com frequencia, especialmente se voce muitas vezes tem que se levantar a noite para ir ao banheiro, pode ser um dos sintomas. Os niveis de acucar no sangue demasiado elevados podem tambem causar a perda de peso rapida, mas esta nao e uma perda de peso saudavel. Como a circulacao e alterada, a pessoa pode ter a pele afetada como coceiras, ressecamento e ma cicatrizacao.
Como os vasos sanguineos sao danificados pelo excesso de glicose circulando, toda a circulacao fica comprometida e entao um pequeno corte ou ferida demora muito mais tempo para cicatrizar. Essa circulacao comprometida tambem pode favorecer o diabetico a sentir formigamento ou amortecimento das maos e pes. At the center of the hemoglobin molecule is a heme group, with an iron atom at the center of it. As it goes through the body, hemoglobin gives up its oxygen to the various cells it comes in contact with. When this wonderful oxygen transport from your lungs, through your heart to the rest of your body is messed up for some reason, you have anemia. I used one of my own prior CBC reports to illustrate white blood cell counts in my last article.
If I were a CLL patient with red blood cell issues, RBC can be much lower than these healthy reference ranges. Anemia is easy to diagnose but not as easy to explain since it can be caused by many different things. Once again, I cannot over emphasize the importance of not getting fixated on any one number but looking for overall trends. MCHC is the average hemoglobin concentration of packed red cells expressed as a percentage.
In CLL patients with sharply lower RBC – perhaps because of AIHA or some of the other reasons discussed below, the bone marrow will register this fact and try to compensate by producing more red blood cells to replace the ones being lost. There are specific reasons for anemia in CLL, over and above the general reasons (poor diet, physical blood loss etc) discussed above. When the problem is too few red blood cells, patients are transfused with “packed red cells” – not whole blood. The risk of infection using standard issue packed red cells is trace levels of viruses (hepatitis is one of the biggest risk factors) that can hide out in the donor white blood cells. Irradiated and leukoreduced blood products are a tad more expensive than the garden variety blood products, but not prohibitively so, and definitely not as expensive as the complications patients can run into if the wrong products are used.
As with most things, too frequent red blood cell transfusions carry the risk of iron overload. You are right that poikilocytosis is the term given to somewhat mis-shapen red blood cells. There are many different reasons why red blood cells can be misshapen, not all of them well understood. I listed Vitamin B1 deficiency in the table under reasons for low hemoglobin, therefore anemia. About two weeks ago my Hemoglobin went rapidly down to 7, so I needed a transfusion to get a better one. I read that erythrocyte concentrates are the better the newer they are and that older ones are from a poorer quality and in so far bad for hosts. Blood banks have very strict guidelines on how long they can keep blood products before they are past their shelf life, so I would not worry about it. LynnS: My maternal grandfather died, like your mother, of complications of aplastic anemia after 6 years or so of blood transfusions. Both my primary care and Oncologist recommended low dose asprin therapy for me as a preventative step to future cardiac events.
Low dose aspirin is likely a good thing to do except for those with aspirin allergy, very low platelet counts or problematic coagulopathies such as Von Willebrands disease, hemophilia, etc. I would love to know more about the spleen and liver and how it copes with a huge mount of lymphocytes eg: 200K. You do a great service in guiding us in the art of knowing when to panic and when to wait out the lower or higher than normal numbers on our blood work and what it all means. CLL Topics Updates does not provide medical advice and its contents are for information only. When a tumor partially obstructs the bowel, it can cause alternating constipation and diarrhea due to leakage of liquid stool.You may also experience frequent gas, abdominal pain, nausea and vomiting.


This increase in blood glucose can be either because of inefficiency of the body to produce insulin, or due to inefficiency of the body cells to respond to insulin.
In fact, it has been observed in studies that as much as 33% of the total population, in the world, suffering from diabetes, has to suffer from different types of skin disorders. So, anyone having a diabetic condition should take these symptoms seriously and get them cured, as early as possible.
This is caused due to hyper pigmentation and occurs mainly in the places, where the skins meet, like, neck, armpits, groin, and under the breasts. This results into the formation of small scaly patches of reddish to brown or light brown color, over the skin. Poor circulation of blood due to damage of blood vessels also leads to itchiness and numbness of skin.
These fungal infections are characterized by the present of sore spots and rashes, which are surrounded by small blisters on all sides.
Patients having any of these symptoms of fungal infection, need to immediately rush to the doctor and get proper medications. These infections are mostly characterized by inflammation of the affected tissue, which is red in color and very painful. These blister resemble those blisters that are developed due to burns and can be of any size, from small to large.
This condition is known as digital sclerosis, and it makes the joints of affected body parts (mostly fingers) stiff and incapable of normal movement. This dryness is also caused due to infection of pathogens, like, fungus, bacteria and virus. These factors include different types of infections, dryness of the skin, and also allergies. This condition affects the legs of the patients and results into hairless, shiny, thin and cold skin.
But, thankfully, you can control these skin conditions, by using proper medication and remedies. Ainda assim, se voce tem sintomas, pode ir mais alem e fazer o exame de curva glicemica classico, com coletas a cada 30 minutos num periodo de 2 a 3 horas, e o exame de nivel de insulina.
Os rins precisam trabalhar muito para eliminar toda a glicose que esta no sangue e por isso quem tem glicemia alta urina mais vezes. Com a glicemia alta, os rins trabalhando a todo o vapor e a necessidade de maior energia (ja que a glicose no sangue nao e utilizada), o organismo passar a utilizar a massa magra.
A acantose nigricans, um escurecimento da regiao do pescoso ou bracos tambem e sinal de que  ja ha uma resistancia a insulina.
Pacientes com a diabetes muito alterada podem evoluir de um simples corte no pe para uma enorme ferida, que se infeccionar leva ate mesmo a amputacao: e o tal do pe diabetico, que precisa de muito cuidado. Alem disso, acorda mais vezes e nao dorme bem a noite, pois precisa sempre ir ao banheiro urinar. Check ups anuais, boa alimentacao, atividade fisica e atencao aos principais sintomas e fundamental para prevenir a diabetes! 6 dicas rapidas para torna-lo mais facilVirginia Sampaio on Preguica de fazer cafe da manha? Since anemia is a common side effect of CLL and causes significant loss of quality of life, we need to learn about it.
Over the years I have seen many thousands of patient CBC reports, people seem to like sending me stuff and ask me to read the tea-leaves. Take out all the water in the red blood cells and pretty much the only thing left is hemoglobin. We said if you take a tube of fresh blood and spin it around fast in a centrifuge, the red blood cells will settle to the bottom and that this layer is just under half the volume of blood in the tube. There is a range of sizes in red blood cells, not all of them are exact copies of each other. It is a derived number, you can calculate MCH by dividing the total amount of hemoglobin by the number of RBC, then multiply by ten to make the units work. You can calculate it by dividing the total amount of hemoglobin by the hematocrit, multiply by 100 to get percentage.
Many of the chemotherapy drugs used to treat CLL are “myelosuppressive” – meaning they damage or reduce the production capacity of stem cells to produce more myeloid cells – red blood cells are part of the myeloid line. The only choices at that point are stem cell transplant with healthy stem cells from a willing donor, or a lifetime of blood transfusion dependency. These are chemical messengers that alert the bone marrow to low RBC; marching orders as it were, that tell the marrow to gear up and increase production.
One of the most common autoimmune diseases in CLL is AIHA (autoimmune hemolytic anemia), where perfectly good red blood cells are targeted and destroyed by the body’s own immune system gone berserk. The red blood cells are separated from blood plasma and from the other cells such as platelets, white blood cells etc by simple process of centrifugation. So, most blood banks recommend using irradiated and leukoreduced blood products for transplant patients as well as patients with any level of immune dysfunction.
I had reason to learn all about this while my husband was going through his stem cell transplant and needed frequent transfusions. Each of those healthy new red blood cells coming into the body carries its own iron atom, and too many transfusions can cause too much accumulation of iron in the body of the patient. The reason for this low Hemoglobin is not yet identified but some reasons like bone marrow infiltration with CLL or autoimmune disease ore some viruses could be excluded.
I am in W&W but this seems counter intuitive as asprin thins the blood and would seem to impact platlets. I have been anemic and you explanation of causes and the meanings of the CBC has been very helpful.
However, it is believed to develop when healthy cells become abnormal and start growing in number and accumulate in the lining of the colon, forming polyps. The skin related symptoms of diabetes may also act as warning signals, to help patients become aware of their fluctuating blood sugar levels.
These blisters are mostly painless and develop, when major fluctuations occur in the blood sugar levels of the patient.
Allergies surface in the form of itching, in diabetic patients, and other skin conditions also normally lead to itching.
Also, as you may have noticed, many skin conditions are result of temporary sugar imbalance, so, if you are diabetic and want to avoid such uncomfortable conditions, try to keep your sugar in control.
Visitar um medico oftalmologista frequentemente e fundamental para acompanhar a saude ocular.
Heck, blood is red because it is full of red blood cells.  Next obvious question, what makes red blood cells red? When hemoglobin comes in contact with oxygen in your lungs, oxygen gets attached to the iron atom.
And as you can see from the reference interval given for healthy individuals, I am doing OK on this front.  Reference ranges are even more important in the case of red blood cells because they are different for men and women. Remember, just because you have CLL does not give you a pass, a get-out-of-jail-free card from all the other things that go wrong with people as they age.
Hematocrit is the volume of red blood cells in a sample of blood, reported as a percentage. For example, newly minted red blood cells are just a bit bigger than older RBC that have been around the block more than a few times.
If there is a robust number of new red blood cells being made, as well as old ones hanging around, RDW will be a high number because the range of sizes of the cells present is broad.


If there are so many CLL cells in the bone marrow that the ‘factory’ is packed to the rafters with these cancerous cells, there is no room left for healthy production of other cells to make up for losses due to normal wear and tear.
If the damage is temporary in nature, production will gradually recover and RBC counts will head back up gradually. AIHA can be detected by Direct Coombs test and looking for antibodies targeting red blood cells. While getting any blood product carries some risk of infection, this risk can be minimized by taking proper precautions. Leukoreduced means they put the packed red blood cells through another step of purification, where the last remnants of white blood cells (“leukocytes”) are removed, since viruses hang out in white blood cells. You can read the details by visiting “Harvey’s Journal”, the on-line blog we maintained so others can learn from our experience through this difficult period of our lives. But this is not something to worry about unless we are talking of patients who are chronically transfusion dependant. I will pass this on to my family as well.I tell them knowledge is wisdom and we need all the wisdom we can muster with this disease. It has been one of the most useful aids in helping me and my Doctors see trends in the progression of my disease. Blood in StoolsMost often, blood in the stool is due to piles (hemorrhoids), where the veins in the back passage become fragile and cause a little bleeding during a bowel movement. They neither itch, not cause irritation, and therefore, they do not demand medical treatment also. These bumps cause itching, and mostly appear on skin of the feet, back of the hand, arms, buttocks and legs.
Estes dois sintomas juntos sao a forma do seu organismo tentar controlar a alta de acucar no sangue.
Sabe aquela abobrinha cozidinha, refogada ou aquele brocolis no vapor ou refogadinho de toda semana? Answer: because red blood cells have a molecule in them called hemoglobin (also spelled as haemoglobin if you are Brit, and abbreviated to Hb, Hgb or Hg) and hemoglobin is colored a bright cherry red when it is rich in oxygen, but more bluish red in color when it has been stripped of its oxygen.
After picking up this precious hitchhiker in the lungs the blood next goes to the heart – the pumping station which circulates blood throughout your body. In my case, the hemoglobin level is a tad low, below the reference range for my lab and hence it is flagged.
A low hematocrit usually indicates decreased production, excessive loss, or destruction of red blood cells.
Cell size can also change depending on dietary issues – B12 and folic acid deficient red blood cells are larger than iron deficient cells. A small RDW number suggests there is no extraordinary amount of red blood cells being made in the bone marrow. This may suggest that in spite of the obvious and  crying need for increased production of red blood cells, the bone marrow is not able to oblige. The remedy is to clean out the bone marrow with appropriate therapy to kill the CLL cells there. Treatment options include prednisone, Rituxan, chemotherapy drugs, spleen removal – some or all of the above, as it becomes necessary. It can also be caused by a digestive disease, such as celiac disease, in which case the treatment may be treating the underlying celiac disease.
I have used multiple institutions, some of which still log in values by hand on crude charts. This type of bleeding is generally red.However, if you notice dark red or black blood in your stool, it can be a sign of cancer, such as bowel, rectal or colon cancer. Arnulfo Candelaria December 27, 2015 at 1:28 pm ReplyI want more information, thank you very much. Did you know hemoglobin is present to the tune of 95-97% by dry weight of red blood cells (if water is counted, then the weight percentage of hemoglobin is around 35%). This oxygenated version of hemoglobin is bright red – which is why arterial blood leaving the heart is bright red. I am a bit anemic, possibly due to low level of iron in my food (I am a vegetarian) and poor absorption of what iron there is in my diet due to early stage Crohn’s disease. Perhaps the marrow is choke full of CLL cells and with the best of intentions the marrow cannot produce new red blood cells because of the infiltration, or perhaps the bone marrow is just not getting the message.  More about this further down. I too have a mild case of poikilocytosis, because of underlying Crohn’s disease (a kind of autoimmune ulceration of the GI tract). DiarrheaIf you suffer from diarrhea for more than a couple of weeks, it may be an early symptom of colon cancer. It can also be due to a stomach ulcer.Whether bleeding is due to piles, a stomach ulcer or cancer, it’s important to get it checked by a doctor.
Think of red blood cells as little sacks full of water and hemoglobin and you will be right on the mark.
Depleted oxygen supply to the cells is slow suffocation, and that is exactly what it feels like. Once the hemoglobin has given up its oxygen to the cells it picks up the waste byproduct of cellular breathing, namely carbon dioxide. Constant Feeling of a Bowel MovementIf you have a constant feeling of urgently needing to have a bowel movement or to strain but no stool is passed, it is not a good sign.
Thank u Chenaix February 6, 2016 at 4:57 pm ReplyI has stage 3 colon cancer and I can say that the very first warning sign, for most cancer is a constant fewer, this occurs cause your body is fighting against the cancer, like it would do, for say the flu. Venous blood returning to the lungs and heart is bluish red in color because hemoglobin with carbon dioxide attached to it is bluish red in color. None of the hemotologists I see or my primary MD seem concerned and I have not gotten much of an explanation for it. This feeling can occur even after having a bowel movement.Changes in your pattern of bowel movements can be a sign of colon cancer. A constant low grade fever is the first sign that you should get tested, followed by fatigue. A tumor present in the left side of the colon obstructs the passageway and often leads to narrow stools.Do not delay discussing any change in your stools with your doctor. Tender Abdomen or Abdominal PainIf your abdomen, especially the lower part, hurts or feels tender when touched, this can be an early indication of tumor growth in the digestive tract, colon or rectum. In fact, abdominal pain is common in people who are later diagnosed with colon cancer.A tumor can cause a block in the colon, restricting blood flow. This pain also can indicate that the cancer has begun to spread to other organs.If abdominal pain or tenderness persists for more than 2 to 3 days, consult your doctor for proper diagnosis.
We would like to make an awarness of the connection of Gallbladder removal & Colon Cancer as well as Birthcontrol.
My Daughter had her Gallbladder removed almost 12 years ago and was also using birth control. Only Colon cancer in our family was an uncle who was diagnosed in his late 70s., , some breast cancer, BUT never someone only 36 years old and in great shape.



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