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Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. This is an excellent presentation on companies and products that are making their mark on the Regenerative Medicine Market. Ovaries are oval-shaped glands located on either side of the uterus, which produce ova and hormones. The oviducts (fallopian tubes) are narrow tubes that attach to the upper part of the uterus, through which the ova travel from the ovaries to the uterus. Induced cardiac progenitor cells (iCPCs) can develop in a dish into contracting heart muscle cells (green) when grown together with other contracting heart muscle cells. By genetically reprogramming the most common type of cell in mammalian connective tissue, researchers at the University of Wisconsin—Madison have generated master heart cells — primitive progenitors that form the developing heart.
Timothy Kamp, leader of the team that transformed mouse fibroblasts into primitive master heart cells. Using the five genes, Lalit, Kamp and their team could push the fibroblast cells back in developmental time to become the cardiac progenitor cells that make cardiomyocytes, smooth muscle cells and endothelial cells — the trio of workhorse cells that make up the organ. The study, explains Lalit, was like an exercise in reverse engineering: observing the genetic factors in play as the heart develops in a mouse embryo and using those to direct the fibroblast down the cardiac developmental pathway or lineage. Induced cardiac progenitor cells (iCPCs) injected into hearts of mice with experimentally induced heart attacks generate new heart muscle. A key advantage of the engineered cardiac progenitor cells, notes Kamp, is that unlike all-purpose pluripotent stem cells, which can become any of the 220 different kinds of cells in the human body, the induced progenitor cells made from fibroblasts are faithful only to the cardiac lineage — a desired feature for cardiac applications. If replicated in human cells, the feat could one day fuel drug discovery, powerful new models for heart disease and the raw material for treating diseased hearts. Lalit and Kamp’s team tested the new cells in mice by experimentally inducing heart attacks. The work was completed by a team of Wisconsin investigators, funded through the National Heart, Lung and Blood Institute’s Progenitor Cell Biology Consortium, part of the National Institutes of Health, and the American Heart Association.
Scientists are utilizing a microbe found in pond scum called Euglena to construct a nanobiodevice that will help detect and treat cancer. The terms bionanotechnology nanobiotechnology and nanobiology refer to the same technology. The Euglena microbe found in pond scum (pea-green surface slicks that form on ponds) are unicellular organisms classified into the Kingdom Protista, and the Phylum Euglenophyta. Scientists are enlisting these living, self-propelled microbes found in pond scum in the development of a long-awaited new test to detect the cells that spread cancer through the bloodstream from the original tumor to new sites in the body.


In a report at the 243rd National Meeting & Exposition of the American Chemical Society (ACS), the world's largest scientific society, they described how the test is intended to not only identify the spreading of cells, but allow lab analysis of those cells so that doctors can decide on the most effective treatment. Baba's team turned to Euglena in an effort to solve the medical problem of detecting the minute number of cancer cells that break off from the original, or primary, tumor site and travel through the bloodstream. Baba's solution is a test that takes place in a lab-on-a-chip, a small device made up of microchambers and channels for the Euglena, which are single-celled organisms with features of both plants and animals. They are working on improvements so that the test will reliably detect very small concentrations of CTCs in real blood samples. Baba also is developing "theranostics," which combine therapy or treatment of disease with diagnostic imaging.
The new quantum dots are biocompatible and are safe for use with living cells, unlike many currently available versions. According to a University of Texas study, Crazy Ants may become the dominant invasive ant species displacing Fire Ants in the near future.
Scientists have successfully placed tiny synthetic motors in live human cells through nanotechnology. The uterus is divided into two parts: the cervix, the lower part that opens into the vagina, and the corpus, the main body of the uterus.
The ovarian follicle is the functional unit of the ovary, in which folliculogenesis, the process of oocyte maturation, takes place. Lalit, found that 11 genes that play a central role in embryonic heart development could be used to reprogram the fibroblasts. The induced cardiac progenitor cells are capable of making billions of the critical heart cells, providing ample material to study heart disease in the laboratory dish, equip high-throughput screens to test various compounds for safety and efficacy, and ultimately, to treat heart disease by replacing diseased cells with healthy ones.
Newly developed heart muscle cells are shown by overlapping red (heart muscle protein) and green (iCPC protein) labeling, and cell nuclei are shown in blue.
A potential drawback of cell transplants derived from all-purpose stem cells is the small but very real possibility of creating a teratoma, a tumor from tissue other than the intended cell lineage. Injecting the engineered cells into the damaged hearts of mice, they observed the cells migrating to the damaged part of the heart and making cardiomyocytes — the heart cells that contract to underpin the beating of the heart — as well as smooth muscle and endothelial cells, key cells that form blood vessels.
It is a is a piece of contrivance, equipment, machine, or component used for biological, medical, and clinical purposes. Those cells, termed circulating tumor cells (CTCs), enable cancer to spread, or metastasize, and start growing at distant sites in the body. Historians think Euglena are the organisms that Dutch microscope pioneer Anton van Leeuwenhoek saw in 1674 in a sample of pond water.


They plan to couple the microchamber to a so-called nanopore, which can sequence the CTC's DNA after the separation to positively confirm cancer metastasis. One of Baba's theranostics involves therapeutic stem cells that are combined with imaging agents called "quantum dots," which are semiconductor crystals that light up when exposed to a special type of light. The quantum dots allowed the researchers to see where the therapeutic stem cells went after they were injected into a mouse.
Following ovulation, the release of a mature ovum, the remaining follicle cells form the corpus luteum. From there, the embryo moves to the uterus, where it is implanted into the lining of the uterine wall, the endometrium. Kamp reports transforming mouse fibroblasts, cells found mostly in connective tissue such as skin, into primitive master heart cells known as induced cardiac progenitor cells.
They are often abundant in quiet, inland waters such as ponds, where they may bloom in numbers sufficient to color the surface of ponds and ditches green (E. They have chlorophyll to produce food from sunlight, for instance, and also can ingest food. The technology could permit a scalable method for making an almost unlimited supply of the three major types of cells in the heart.
Importantly, the group also defined the conditions necessary for the transformed cells to be effectively cultured in the laboratory. Detecting those cells would raise a red flag so that doctors could treat or more intensively monitor patients.
They have a primitive "eye" and a long tail or flagellum that moves like a whip to propel them through the water. The microbe (with antibody attached) is then placed into a microchamber that contains normal cells and a single CTC, simulating the very low concentration of CTCs that would be in a real cancer patient's blood sample.
When the researchers shine a light on the microchamber, the Euglena, with CTC in tow, moves to a neighboring microchamber to escape from the light.



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