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Diabetes Medications Insulin 1922 Metformin Sitagliptin Saxagliptin SUs AGIs 2006 2009 1957 1995 1960 1995 2000 2005 2010 Glinides Exenatide TZDs Pramlintide Liraglutide 1997 2005 2010 Philippe J. Incretin Physiology ? GLP-1 – Stimulates glucose-dependent insulin secretion from beta cel s – Suppresses glucagon release from alpha cel s– Slows gastric emptying & reduces food intake– Degraded by DPP-4 enzyme ? GIP – Increases glucose-dependent insulin release– Degraded by DPP-4 enzyme 1. Saxagliptin (Onglyza®) ? FDA approved July 2009 – Bristol-Myers Squibb ? Second DPP-IV inhibitor? Adjunct to diet & exercise to improve glycemic control in patients with T2DM – Do not use in T1DM or DKA– No data in combination with insulin 1.
Canaglifozin, the generic name for the new medication, works by blocking the action of SGLT, which allows the blood sugar circulating in the blood to remain in the blood stream during filtration by the kidneys. Invokana received approval after nine clinical trials involving more than 10,000 participants where the drug demonstrated improvement in both fasting blood glucose levels and hemoglobin A1C levels. Johnson & Johnson is currently seeking approval for the new medication in Europe, where it would become the second such drug in its class to dapagliflozin, a Bristol-Myers Squibb and AstraZeneca product that was rejected approval in the United States due to safety concerns. Sales totaling $111 million in 2013 and up to $667 million by 2016 have been predicted by Lawrence Biegelsen of Wells Fargo.
The studies will evaluate heart-related outcomes, serious cases of pancreatitis, any malignancies that develop, severe allergic reactions, liver abnormalities, adverse pregnancy outcomes, bone safety, photosensitivity reactions and two pediatric studies. The Journal of the American Medical Association’s Internal Medicine reported results of a study that revealed baby boomers have a higher risk for chronic diseases, including diabetes, than do their parents despite the advances of health care over the lifespan of the boomers. Manna Research is looking for individuals with Type 2 Diabetes to participate in a clinical research trial to help control blood sugar levels. We have over 40 years of combined & trusted experience conducting clinical research studies to thoroughly test new medications or medical devices for safety and efficacy.


Some people are worried about diabetes early symptoms or that they might have diabetes or might be at risk of having it in nearly future. Anyway, this is not to scary you, but only to make you conscious of possible warning signs diabetes. But you must educate yourself on recognizing them, in order not to let your body go to complications, severe diabetes complications. Secondly, most of diabetes early symptoms are common for both two types of diabetes, type 1 and type 2.
Also, you must keep in mind some other particular features to make you part of diabetic population. Is your Diabetic Heart Killing you softly?Get to know about Diabetes Heart Failure link to more severe complications. Without enough insulin to move sugar into the cells, your muscles and organs are depleted of energy. If your blood sugar in the blood is too high, fluid may be pulled from your tissues - including the lenses of your eyes. Consult your doctor if you are concerned about diabetes or if you notice signs and type 1 diabetes symptoms.
If you interesting in "New Drugs for Type 2 Diabetes: The Incretins" powerpoint themes, you can download to use this powerpoint template for your own presentation template. Food and Drug Administration approved the first of a new type of medication to treat type 2 diabetes.


This medication inhibits that normal process, allowing the kidneys to instead filter out excess blood glucose for excretion in the urine the U.S.
Fasting blood glucose lab testing measures the about of sugar circulating in the blood that is representative of current blood glucose levels; hemoglobin A1c lab testing provides an average of circulating sugar in the blood over a period of three months. FDA has required that Johnson & Johnson conduct five post-marketing studies for canaglifozin due to findings that occurred during the initial nice clinical trials, but whose incidence was deemed as not significant to the approval process by the federal agency. The results of these studies will aid in determination of whether the medication continues to fall within safety standards and what warnings or precautions should be observed with its use.
We are one of the largest networks of fully-owned and integrated outpatient clinical research sites in North America. Alba, What would be the glucose reaction if I eat 2 scrambled eggs with 2 slices of salt-cured bacon and one slice of wholegrain toast? For viewing only, you can play with our flash based presentation viewer instead of downloading the ppt file.
Nearly 26 million people have diabetes in the United States alone, and some 347 million people have the chronic disease worldwide, with type 2 diabetes being the most common form of the condition.
Both are tests that health care providers use as parameters to diagnose and treat diabetes.



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