Metformin monotherapy for type 2 diabetes mellitus cochrane database of systematic reviews,diabetes free legit 2014,leendert jan vis rij - Downloads 2016


Han transcurrido mas de 5 anos desde la publicacion de esta Guia de Practica Clinica y esta pendiente su actualizacion.
Se debe revisar la necesidad de continuar con la sulfonilurea o de disminuir su dosis por el riesgo de hipoglucemias.
Las recomendaciones que contiene han de ser consideradas con precaucion teniendo en cuenta que esta pendiente evaluar su vigencia. El aumento de peso es menor con las pautas nocturnas de insulina asociada a metformina (con sulfonilureas o sin ellas) frente a la monoterapia con insulina (98). En pacientes con DM 2 tampoco existen diferencias en los episodios de hipoglucemias (107; 108).
Tres de ellas estudian la insulina glargina y detemir frente a NPH, mientras que la tercera (104), financiada por el fabricante, tiene como objetivo evaluar los episodios de hipoglucemia de insulina glargina. Insulin monotherapy versus combinations of insulin with oral hypoglycaemic agents in patients with type 2 diabetes mellitus. Continuing metformin when starting insulin in patients with Type 2 diabetes: a double-blind randomized placebo-controlled trial. Comparison of basal insulin added to oral agents versus twice-daily premixed insulin as initial insulin therapy for type 2 diabetes.
Long-acting insulin analogues versus NPH insulin (human isophane insulin) for type 2 diabetes mellitus.
Reduced hypoglycemia risk with insulin glargine: a meta-analysis comparing insulin glargine with human NPH insulin in type 2 diabetes.
Systematic review and economic evaluation of a long-acting insulin analogue, insulin glargine. Short-acting insulin analogues for diabetes mellitus:meta-analysisi of clinical outcomes and assessment of cost-effectiveness [Technology Report no 87]. Short acting insulin analogues versus regular human insulin in patients with diabetes mellitus.



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