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O diabetes mellitus e uma doenca definida pela falta de insulina ou de sua incapacidade de exercer adequadamente seus efeitos provocando uma resistencia a insulina. A gestacional e caracterizada pela presenca de glicose elevada na gravidez e normalmente e normalizada apos o parto, entretanto, mulheres que apresentaram esse quadro na gestacao sao mais propensas a desenvolverem diabetes tipo 2 tardia.
No caso dos carboidratos o ideal e dar preferencia aos complexos, ou seja, ricos em fibras para que nao ocorra uma hiperglicemia como os integrais, cereais, legumes, verduras e algumas frutas.
Em novembro de 2012 a International Diabetes Federation publicou o seguinte: ha no mundo cerca de 371 milhoes de pessoas portadoras de diabetes com idades entre 20-79 anos de idade, o numero de portadores e crescente em todos os paises, 50% das pessoas portadores desconhecem esta condicao e, o Brasil ocupa a 4? colocacao entre os paises de maior prevalencia, 13,4 milhoes de pessoas, o que corresponde a 6,5% da populacao entre 20-79 anos de idade. Neste dia 14 de novembro e comemorado o dia Mundial da Diabetes que tem o intuito de levar informacao as pessoas sobre a doenca, seu diagnostico e tratamento. Os sintomas mais comuns sao urinar excessivamente, inclusive acordar varias vezes a noite para urinar, sede excessiva, aumento de apetite, perda de peso, cansaco, vista embacada e infeccoes frequentes, sendo as mais comuns as de pele.
De maneira geral os exercicios fisicos sao beneficos para os portadores de diabetes, principalmente os do tipo 2. A pratica de exercicios fisicos so e recomendada quando os niveis de glicose sanguineos estao sob controle mediante o uso da insulina ou de outro medicamento que module a glicose e de dieta adequada. A diabetes mellitus, principalmente a do tipo 2, e uma doenca crescente e um dos fatores de risco para o seu surgimento e o de doencas cardiovasculares e a obesidade.
A microcirculacao inclui as arteriolas, capilares e venulas sendo essencial para o equilibrio do metabolismo dos tecidos assim como a pressao arterial. Um endotelio normal e capaz de secretar substancias vasodilatadoras e fator hiperpolarizante promovendo a manutencao do tonus vascular, regulacao da agregacao plaquetaria e da coagulacao, modulando a inflamacao e diminuindo o risco de trombos e futuramente de uma aterosclerose. Over the past few decades there has been considerable focus on the effect of exercise, diet, aging and disease on mitochondrial health.A  Understanding the basic physiology of mitochondria and how they replicate in response to your lifestyle can have profound impacts on your overall health. Simply stated, mitochondria produce ATP, and ATP is absolutely essential for survival.A  Without a sufficient generation of ATP, life would cease to exist. Red muscles contain a large quantity of mitochondria, white muscles contain fewer mitochondria and mixed muscles contain both red and white muscle fiber types.A  Whereas a single cell contains one nucleus, muscle cells often contain hundreds or even thousands of mitochondria in order to support the generation of large quantities of ATP during exercise.
In this electron micrograph, many adjacent mitochondria are visible within the muscle cell.A  Ita€™s no coincidence that they are located close to one another a€“ they do that in order to share glucose, amino acids and fatty acids in order to distribute the production of ATP across a coordinately linked network. Mitochondrial biogenesis is a process that was first described over 40 years ago by a pioneer in the field of exercise physiology named John Holloszy, a professor at Washington University in St. For more information on why glucose is your best friend during and after exercise, read What Happens to Muscles During Exercise and Eating for Optimal Muscle Recovery: Carbohydrates are Not the Enemy. The result of mitochondrial biogenesis is an expansion of the network of mitochondria within a cell, and an increase in the maximal amount of ATP that can be generated during intense exercise.A  In short a€“ more mitochondria means more ATP production at peak exercise conditions. Exercise is the most potent signal for the increased production of mitochondria in muscle, by increasing the ability of the muscle to burn carbohydrates and fatty acids for ATP.
By doing this, mitochondria are able to consume larger amounts of oxygen, carbohydrates and fatty acids, the fuels needed to power the production of ATP.A  The ability of muscles to overcompensate for exercise a€?stressa€? is exactly why frequent exercise results in increased strength, endurance, resistance to fatigue and whole body fitness.
It turns out that the amount of mitochondrial biogenesis that occurs in response to aerobic (endurance) exercise, resistance exercise (bodyweight exercise and weight training) or high intensity interval training (HIIT) are similar but not equal. Aerobic exercise is the most extensively studied type, and has been shown to induce large increases in muscle mitochondria and the ability to oxidize glucose as fuel.A  Endurance training such as jogging, running, cycling, swimming and cross country skiing result in profound increases in aerobic capacity, muscular endurance and resistance to fatigue over the long-term, all of which are made possible by mitochondrial biogenesis at the cellular level.
Resistance training such as FitStar, Crossfit, weight lifting and body weight training can amplify the signal for mitochondrial biogenesis beyond that of aerobic exercise by itself, resulting in increased aerobic capacity, strength and resistance to fatigue.A  Performing a combination of resistance and aerobic exercise enhances mitochondrial biogenesis beyond that of either form of exercise in isolation. High intensity interval training (HIIT) is characterized by repeated bursts of brief intense exercise interspersed with periods of brief recovery, and include popular sports such as soccer, lacrosse, wrestling, basketball and Crossfit, to name a few.A  HIIT has been shown to increase muscle mitochondrial ATP production and improve muscle endurance despite a significantly reduced total exercise volume than traditional aerobic exercise. In conclusion, a single bout of low-volume HIIT can activate mitochondrial biogenesis and even double endurance capacity as compared with aerobic exercise of the same energy expenditure. So the next time you perform a FitStar workout, imagine the work that your mitochondria are doing to keep up with the a€?stressa€? you create.A  I assure you, the behind-the-scenes work is nothing short of magical. I am a firm believer of all of them, normal aerobic training, resistance training and HIIT which I have been practicing for years. This is one of the most powerful reasons to keep going and to think in being a FitStar Athlete!
Do you think that we can acheive “almost” the same results via, a combination of yoga stretching and bodyscanning or some kind of autogenic training?
Question: if time or training volume isn’t limiting factor is hiit best or lots of endurance miles better? If a company reports earnings of $1 billion, does this mean it has this amount of cash in the bank? An outflow of cash occurs when a company transfers funds to another party (either physically or electronically).
A cash inflow is of course the exact opposite; it is any transfer of money that comes into the company's possession. Cash Flow vs Income It is important to note the distinction between being profitable and having positive cash flow transactions: just because a company is bringing in cash does not mean it is making a profit (and vice versa).
For example, say a manufacturing company is experiencing low product demand and therefore decides to sell off half its factory equipment at liquidation prices. The cash flow statement differs from these other financial statements because it acts as a kind of corporate checkbook that reconciles the other two statements. Cash flow from operating activities - This section measures the cash used or provided by a company\'s normal operations. Cash flows from investing activities - This area lists all the cash used or provided by the purchase and sale of income-producing assets. Cash flows from financing activities - This section measures the flow of cash between a firm and its owners and creditors. The "Net Cash from Operating Activities" reveals that Microsoft generated $14.6 billion in positive cash flow from its usual business operations - a good sign.
Digging Deeper into Cash Flow All companies provide cash flow statements as part of their financial statements, but cash flow (net change in cash and equivalents) can also be calculated as net income plus depreciation and other non-cash items.
Generally, a company's principal industry of operation determine what is considered proper cash flow levels; comparing a company's cash flow against its industry peers is a good way to gauge the health of its cash flow situation.
Even a company that is shown to be profitable according to accounting standards can go under if there isn't enough cash on hand to pay bills.
As it doesn't tell the whole profitability story, cash flow doesn't do a very good job of indicating the overall financial well-being of the company.
In other words, the cash flow statement is a compressed version of the company's checkbook that includes a few other items that affect cash, like the financing section, which shows how much the company spent or collected from the repurchase or sale of stock, the amount of issuance or retirement of debt and the amount the company paid out in dividends. The Bottom Line Like so much in the world of finance, the cash flow statement is not straightforward. At the same time, while investing in a company that shows positive cash flow is desirable, there are also opportunities in companies that aren't yet cash-flow positive. The main function of the pancreas is to produce digestive enzymes and hormones, such as insulin, that regulate blood sugar levels.
In some uncommon cases, a single severe episode of acute pancreatitis can cause enough damage that the disease becomes chronic. Heredity — Hereditary chronic pancreatitis is a rare genetic disorder that predisposes a person to develop the disease, usually before age 20. Genetic causes – Mutations of the cystic fibrosis gene is the most widely recognized genetic cause. Autoimmune pancreatitis – For unexplained reasons, some people develop antibodies that attack their own pancreas. The most common symptom is upper abdominal pain, which often radiates to the back and may be accompanied by nausea, vomiting and loss of appetite. Because a damaged pancreas can’t produce important digestive enzymes, people with chronic pancreatitis may develop problems with digesting and absorbing food and nutrients.

A computed tomography (CT) scan, magnetic resonance imaging (MRI), or ultrasound to detect inflammation, scarring, and possible tumors of the pancreas.
A test called endoscopic retrograde cholangiopancreatography (ERCP), in which the patient swallows a small tube with a camera at the end, which passes through the stomach and into the small intestine. A noninvasive imaging test called magnetic resonance cholangiopancreatography (MRCP), which evaluates the ducts without requiring an endoscope or contrast material.
Since most cases of chronic pancreatitis are associated with alcohol use, the best way to prevent the problem is to avoid or limit alcohol use.
If blocked bile or pancreatic ducts can be opened by surgery or ERCP, it may prevent further damage to the pancreas.
Because chronic pancreatitis cannot be cured, treatment is directed toward relieving pain, improving food absorption, and treating diabetes. For milder types of pain, medications such as acetaminophen (Tylenol) or ibuprofen (Advil, Motrin and others) may help. In rare cases, surgery to open blocked ducts or remove part of the pancreas may be done to relieve pain. Problems absorbing food, and the resulting vitamin deficiencies, can be helped by taking supplemental digestive enzymes in pill or capsule form.
Although chronic pancreatitis is an incurable condition, the severity, frequency and type of symptoms can vary.
Normalmente as complicacoes incluem queixas visuais, cardiacas, circulatorias, digestivas, renais, urinarias, neurologicas, dermatologicas e ortopedias, entre outras.
Proximo a 90% dos portadores e do tipo 2, pouco sintomatica e por isso favorece a ocorrencia de complicacoes. Caso apresente algum desses sintomas a conduta mais adequada e procurar um medico para diagnosticar se ha ou nao a diabetes e iniciar o tratamento. O objetivo dos exercicios e a otimizacao da capacidade funcional, controle do peso corporal, modulacao dos niveis glicemicos e reducao de fatores metabolicos de risco para o desenvolvimento de doencas cardiovasculares. Os exercicios ajudam o corpo a responder melhor a insulina e a transportar de modo mais eficiente a glicose para dentro das celulas. Muitas vezes os diabeticos possuem outras patologias associadas e estas devem ser analisadas para que haja a melhor indicacao de uma atividade. Vem sendo demonstrado que a disfuncao microvascular afeta a disponibilidade de glicose mediada por insulina e a resistencia vascular periferica, contribuindo para a resistencia a insulina e a hipertensao. Ela e regulada principalmente pelas celulas endoteliais que promovem efeitos vasodilatadores ou vasoconstritores.
O controle do nivel glicemico reduz o risco dessas complicacoes microvasculares por isso a necessidade de um acompanhamento medico e nutricional. A lot of Lyme Disease patients are in so much pain that it is hard to justify exercising, but the way you lay this out makes it pretty clear to me that whatever exercise chronically ill patients can do, they should do. And, let me tell you, I feel not only superb but also the fittest and healthiest man in the world! Business is all about trade, the exchange of value between two or more parties, and cash is the asset needed for participation in the economic system. Such a transfer could be made to pay for employees, suppliers and creditors, or to purchase long-term assets and investments, or even pay for legal expenses and lawsuit settlements. Typically, the majority of a company's cash inflows are from customers, lenders (such as banks or bondholders) and investors who purchase company equity from the company. It will receive cash from the buyer for the used equipment, but the manufacturing company is definitely losing money on the sale: it would prefer to use the equipment to manufacture products and earn an operating profit.
There are three important parts of a company's financial statements: the balance sheet, the income statement and the cash flow statement. Simply put, the cash flow statement records the company's cash transactions (the inflows and outflows) during the given period. It shows the company\'s ability to generate consistently positive cash flow from operations.
If Microsoft, again our example, bought or sold companies for a profit or loss, the resulting figures would be included in this section of the cash flow statement. Negative numbers can mean the company is servicing debt but can also mean the company is making dividend payments and stock repurchases, which investors might be glad to see. If you check under current assets on the balance sheet, you will find cash and cash equivalents (CCE or CC&E).
Notice the company has had similar levels of positive operating cash flow for several years. A company not generating the same amount of cash as competitors is bound to lose out when times get rough. Comparing amount of cash generated to outstanding debt, known as the operating cash flow ratio, illustrates the company's ability to service its loans and interest payments. Every company filing reports with the Securities and Exchange Commission (SEC) is required to include a cash flow statement with its quarterly and annual reports. Sure, the statement of cash flow indicates what the company is doing with its cash and where cash is being generated, but these do not reflect the company's entire financial condition. You must understand the extent to which a company relies on the capital markets and the extent to which it relies on the cash it has itself generated.
People with chronic pancreatitis have persistent inflammation of the pancreas that leads to permanent damage. Damage to the pancreas can cause problems with digestion, absorption of nutrients, and production of insulin. Blockage can be caused by gallstones, scarring from prior surgery, tumors, or abnormalities of the pancreas or of the shape or location of the pancreatic duct. This can lead to weight loss, vitamin deficiencies, diarrhea and greasy, foul-smelling stools. If you have long-lasting abdominal pain or signs that your food is not being properly absorbed, such as weight loss or greasy stools, your doctor will ask you about alcohol use, and other factors that increase your risk of chronic pancreatitis and other digestive problems. These enzymes typically are elevated in people with acute pancreatitis, but are often normal in people with chronic pancreatitis. At the site where the bile and pancreatic ducts empty into the small intestine, dye is injected through a small tube into the ducts, which then light up on an X-ray.
For this reason, diabetes and other problems that are associated with chronic pancreatitis require long-term treatment. Anyone who has had an episode of alcohol-related acute pancreatitis should stop drinking entirely to lower the possibility of developing chronic pancreatitis. Your doctor also may recommend that you follow a low-carbohydrate, high-protein diet that also restricts some types of fats. Some people — especially those who quit drinking alcohol entirely — have very mild or occasional symptoms that are easily managed with medications. A tipo 1 consiste em uma producao de insulina pelo pancreas insuficiente e os seus portadores necessitam de doses diarias de insulina para a manutencao da glicose. Para que nao haja a presenca dessas complicacoes e necessaria uma dieta adequada visando o controle da glicemia. Proteinas magras como peixes e frango sao mais indicadas por terem menor teor de gorduras saturadas. Os fatores de risco para essa doenca sao: familiares proximos portadores, idade maior do que 45 anos, excesso de peso ou obesidade, pressao arterial alta, colesterol elevado e mulheres com antecedentes de filho nascido com mais de 4 kg.
O primeiro passo para ingressar em uma atividade fisica e solicitar um exame de sangue para verificar o nivel de glicose e realizar uma avaliacao fisica. Tambem ajudam a diminuir os niveis de glicose no sangue durante e por ate 48h apos a atividade.

A pratica de exercicios ao final da tarde e inicio da noite nao sao indicadas, devido o pico natural da insulina o que aumenta as chances de uma hipoglicemia noturna.
Pesquisadores relacionam alteracoes na microcirculacao em pacientes diabeticos devido a resistencia a insulina.
A microcirculacao no diabetes: implicacoes nas complicacoes cronicas e tratamento da doenca. Perivascular fat and the microcirculation: relevance to insulin resistance, diabetes, and cardiovascular disease. It was written by Cyrus Khambatta, a good friend of FitStar, and he might have the answers you seek. Financial statements are based on accrual accounting, which takes into account non-cash items.
For this reason - while some industries are more cash intensive than others - no business can survive in the long run without generating positive cash flow per share for its shareholders. It is important to note that legal transfers of value through debt - a purchase made on credit - is not recorded as a cash outflow until the money actually leaves the company's hands. Occasionally cash flows come from sources like legal settlements or the sale of company real estate or equipment.
But since it cannot, the next best option is to sell off the equipment at prices much lower than the company paid for it.
The balance sheet gives a one-time snapshot of a company's assets and liabilities (see Reading the Balance Sheet).
It shows whether all those lovely revenues booked on the income statement have actually been collected.
If you take the difference between the current CCE and last year's or last quarter's, you'll get this same number found at the bottom of the statement of cash flows. If this number were to increase or decrease significantly in the upcoming year, it would be a signal of some underlying change in the company's ability to generate cash. If a slight drop in a company's quarterly cash flow would jeopardize its loan payments, that company carries more risk than a company with stronger cash flow levels. Unless tainted by outright fraud, this statement tells the whole story of cash flow: either the company has cash or it doesn't.
The cash flow statement does not account for liabilities and assets, which are recorded on the balance sheet.
No matter how profitable a company may be, if it doesn't have the cash to pay its bills, it will be in serious trouble.
So, analyzing it together with the other statements can give you a more overall look at a company' financial health. As a result, people with chronic pancreatitis can lose weight, experience diarrhea, become malnourished with vitamin deficiencies and develop diabetes. Since only 5% to 10% of alcoholics develop chronic pancreatitis, there probably are other factors that influence whether someone develops chronic pancreatitis. If the blockage is found early, surgery or a procedure called endoscopic retrograde cholangiopancreatography (ERCP) to relieve the blockage may help to prevent damage to the pancreas. As the disease gets worse and more of the pancreas is destroyed, pain may actually become less severe. Over time, a damaged pancreas also can fail to produce enough insulin, which results in diabetes.
It is unclear why pain develops with chronic pancreatitis, but once chronic pain develops, it tends to be long-lasting or even lifelong. People who have been diagnosed with chronic pancreatitis can prevent further damage by eliminating alcohol use. However, only a minority of people with chronic pancreatitis actually benefit from this procedure.
Other people — especially those who continue to drink alcohol — can have disabling, daily pain and may require frequent hospitalizations. Pode ocorrer em qualquer idade, mas e mais comum em criancas, adolescentes e adultos jovens. Deve haver um consenso entre o medico, educador fisico e nutricionista a fim de indicar o melhor tratamento medicamentoso, nutricional e de uma atividade fisica adequada. O dano endotelial presente na diabetes parece ser o fator desencadeante das complicacoes microvasculares como a cegueira por retinopatia diabetica, doenca renal terminal e amputacao dos membros.
To have a positive cash flow, the company's long-term cash inflows need to exceed its long-term cash outflows. In the year that it sold the equipment, the company would end up with a strong positive cash flow, but its current and future earnings potential would be fairly bleak.
And the income statement indicates the business's profitability during a certain period (see Understanding The Income Statement).
At the same time, however, remember that the cash flow does not necessarily show all the company's expenses: not all expenses the company accrues have to be paid right away. What Cash Flow Doesn't Tell Us Cash is one of the major lubricants of business activity, but there are certain things that cash flow doesn't shed light on. Furthermore accounts receivable and accounts payable, each of which can be very large for a company, are also not reflected in the cash flow statement.
Remain diligent in your analysis of a company's cash flow statement and you will be well on your way to removing the risk of one of your stocks falling victim to a cash flow crunch.
It is generally thought that people who continue to drink after one or more bouts of alcohol-related acute pancreatitis are more likely to develop chronic pancreatitis. During an attack, the pain often is made worse by drinking alcohol or eating a large meal high in fats. A tipo 2 corresponde a 90% dos casos, ocorrendo normalmente em obesos, pessoas com mais de 40 anos, com dieta inadequada, sedentarias e normalmente e assintomatica podendo levar a complicacoes.
Frutas mais doces como o mamao, a banana, a manga, o acai e suco de laranja devem ser consumidas com cautela.
Alguns estudos indicam que os exercicios ajudem na diminuicao da insulina e dos medicamentos necessarios para o controle da glicemia ja que provoca o aumento da sensibilidade dos tecidos a insulina. However, accrual accounting may create accounting noise, which sometimes needs to be tuned out so that it's clear how much actual cash a company is generating. Because cash flow can be positive while profitability is negative, investors should analyze income statements as well as cash flow statements, not just one or the other. So even though the company may have incurred liabilities it must eventually pay, expenses are not recorded as a cash outflow until they are paid (see the section "What Cash Flow Doesn't Tell Us" below). For example, as we explained above, it doesn't tell us the profit earned or lost during a particular period: profitability is composed also of things that are not cash based.
O ideal e uma consulta com um nutricionista para que este avalie a melhor dieta para cada individuo. The statement of cash flow provides this information, and here we look at what cash flow is and how to read the cash flow statement. This is true even for numbers on the cash flow statement like "cash increase from sales minus expenses", which may sound like they are indication of profit but are not.

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