Insulin therapy in type 1 diabetes pdf reader,blood sugar level range normal,treatment of diabetes by ayurveda 63 - Easy Way


Type 1 diabetes mellitus (sometimes called insulin-dependent diabetes) is a chronic disease that occurs when the pancreas produces little or no insulin.
In 2011 the International Diabetes Federation estimated more than 350 million people worldwide suffered from diabetes and expected an increase to more than 550 million people by 2030. Insulin replacement by needle injection and subcutaneous pumps has had a huge impact on extending the lives of millions of patients with diabetes.
Pancreas transplantation has resulted in insulin independence in most patients during the first year after transplant, but it is also associated with a risk of complications from surgery, as well as long-term immunosuppression treatments. Another option is transplanting just the cells in the pancreas that produce insulin, which is much less invasive as procedures go (injection of cells under portal vein under local anesthesia).
Gene therapy on the other hand looks to insert a properly functioning version of the insulin producing gene back into your own cells.
Work in this area over the last decade has produce some very promising results in reprogramming liver, gut, and pancreatic cells into insulin producing cells. Callejas D, Mann CJ, Ayuso E, Lage R, Grifoll I, Roca C, Andaluz A, Ruiz-de Gopegui R, Montane J, Munoz S, Ferre T, Haurigot V, Zhou S, Ruberte J, Mingozzi F, High K, Garcia F, Bosch F. In type 1 diabetes the pancreas no longer produces insulin (or at least not a significant amount) therefore the primary type 1 diabetes treatment consists of giving the body insulin as closely as we can to the way the body would do it naturally.
There is no one right way to manage diabetes, since many different types of insulin treatment can successfully control blood sugar levels.  The type of insulin treatment varies from person to person, and can depend on many individual factors – including age and life style. Many type 1 diabetics have what is called a ‘honeymoon’ period for the first few months (or even year) after being diagnosed. Over time, people with type 1 diabetes usually learn to adjust their own insulin dose, although you will need help from time to time.
There are a few types of insulin, which can be used alone or in combination in order to treat type 1 diabetes.
There are two general types of insulin treatment plans: intensive insulin treatment and standard (conventional) insulin treatment.


Intensive insulin treatment — Intensive insulin treatment is best for keeping blood sugar in tight control. Intensive insulin therapy is recommended for most people with type 1 diabetes because it gives you the best chance for successful blood sugar control, and it is best to start it as soon as possible. The drawback to intensive insulin control is that you might experience a higher rate of low blood sugars (hypoglycemia) and it is about 3 times as expensive as standard insulin treatment.
Intensive insulin therapy usually entails a long acting insulin (like glargine or detemir) that is used as a basal insulin, and an additional rapid insulin (lispro, aspart, or glusine) every time you eat.
The Diabetes Media Foundation is a 501(c)(3) tax-exempt nonprofit media organization devoted to informing, educating, and generating community around living a healthy life with diabetes.
People with this form of diabetes require injections of insulin every day to control the glucose levels in their blood, or they will die. Type 1 diabetes accounts for approximately 5% of all cases of diabetes and it is estimated that 78 000 children develop type 1 diabetes every year. This solution is not ideal however, as it still typically means a reduced lifespan, intensive disease management, and a high likelihood of developing debilitating complications. Considered a highly effective therapy inducing sustained insulin independence or reduced insulin requirements in most patients. A group in Spain last month reported they replaced two genes to cure a dog of type 1 diabetes using a similar approach.
Treatment of Diabetes and Long-term Survival Following Insulin and Glucokinase Gene Therapy.
Insulin requirements are relatively lower during this time, and when it ends patients insulin needs rise dramatically. Changes in weight, diet, health conditions (including pregnancy), activity level, emotional states, and work can affect the amount of insulin you need to take in order to control your blood sugar. Most people with type 1 diabetes meet with a doctor or nurse every three to four months, and review blood sugar levels and insulin doses at these visits, helping to fine-tune diabetes control.


You will need to take 3 or more insulin shots per day or use an insulin pump, and you will need to check your blood sugar frequently.
However, this regimen will be successful only if you are fully committed to it and you have good understanding of the regimen—this means checking your sugars 4 or more times a day. The only draw backs to this therapy are the shortage of high-quality donor cells, long-term graft failure, and the risks associated with long term immunosuppression.
I first heard of a group out in BC working on this using gut endocrine stem cells (cells in the lining of your gut that reproduce to form various cell types) back in the early 2000’s.
Although the technology requires more testing before human clinical trials can be started, the continued advancements in this technology provide hope for those searching for a cure to diabetes. Standard insulin treatment is an older regimen, although it may still be recommended for selected patients.
The idea being that these cells would be able to detect blood glucose levels and then produce insulin responsively.
The group eventually started the company EnGene that now works on a multitude of gene therapy and protein delivery solutions. Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada.
Center of Animal Biotechnology and Gene Therapy, Universitat Autonoma de Barcelona, Bellaterra, Barcelona, Spain.



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