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Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. Clipping is a handy way to collect and organize the most important slides from a presentation. The randomized, controlled OpT2mise study was sponsored by Medtronic and conducted with participation from 331 patients, ranging in age from 30 to 75 years. Study findings showed that MiniMed insulin pumps safely provided significant, sustainable and reproducible improvements in glucose control in comparison to MDI.
Initial results of OpT2mise showed that after six months, people with insulin-requiring type 2 diabetes who used insulin pumps achieved better glucose control than those using MDI. The Diabetes Media Foundation is a 501(c)(3) tax-exempt nonprofit media organization devoted to informing, educating, and generating community around living a healthy life with diabetes. Please, complete the form with your suscription data.If you are a member of the Spanish Society of Cardiology, you can use the same login and password that you use to access the Society's website. Initial six-month study results comparing MiniMed insulin pump therapy to MDI were published in The Lancet in July 2014. Daryl Norwood Diabetes CasePresentationR.C is a 57-year-old man with Type 2 diabetes first diagnosed two years ago.
Daryl Norwood Weight changes should be monitored to assess the need for more aggressive treatments or diet restriction. The OpT2mise study is the largest randomized controlled trial to compare the efficacy and safety of insulin pump therapy versus multiple daily injections (MDI) for poorly controlled type 2 patients.


The MDI group, which switched to insulin pump therapy after six months, experienced a similar reduction in A1C to the results seen in the original insulin pump group.
Additionally, at the end of the continuation phase, participants who switched from MDI to insulin pump showed a 19.0% reduction in total daily insulin dose, making it equivalent in both treatment arms. In addition to its contributions to hyperglycemia, alcohol has a negative interaction on the drugs Metformin and Simvastatin that can cause liver toxicities.
To achieve adequate control of diabetes, lifestyle modifications are an important part of therapy.
Dietary restrictions, increase in physical activity, and gradual weight loss will be more beneficial than taking medication, alone.
Body fat distribution, rather than overall adiposity, influences serum lipids and lipoproteins in healthy men independently of age. Yusuf S, Hawken S, Ounpuu S, Bautista L, Franzosi MG, Commerford P, et al; INTERHEART Study Investigators. Obesity and the risk of myocardial infarction in 27,000 participants from 52 countries: a case-control study. Globalization, coca-colonization and the chronic disease epidemic: can the doomsday scenario be averted? Primary prevention of cardiovascular diseases in people with diabetes mellitus: a scientific statement from the American Heart Association and the American Diabetes Association.
Toumilehto J, Lindstrom J, Eriksson JG, Valle TT, Hamalainen H, Ilanne-Parikka P, et al; Finnish Diabetes Prevention Study Group.


Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance.
Obesity and cardiovascular disease: pathophysiology, evaluation, and effect of weight loss.
An Update of the 1997 American Heart Association Scientific Statement on Obesity and Heart Disease From the Obesity Committee of the Council on Nutrition, Physical Activity, and Metabolism.
Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight reduction and cardiovascular risk factors in overweight patients: 1-year experience form the RIO-Europe study.
Efficacy and tolerability of rimonabant in overweight or obese patient with type 2 diabetes: a randomised controlled study.
Efficacy and safety of the weight-loss drug rimonabant: a meta-analysis of randomised trials. Malmberg K, Ryden L, Wedel H, Birkeland K, Bootsma A, Dickstein K, et al; DIGAMI 2 Investigators.
Intense metabolic control by means of insulin in patients with diabetes mellitus and acute myocardial infarction (DIGAMI 2): effects on mortality and morbidity.



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