Fisiopatologia de la diabetes tipo 2 diapositivas,telltale signs of type 2 diabetes diet,luseogliflozin for the treatment of type 2 diabetes genetic - Review


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DEFINICIONEnfermedad caracterizada por una destruccion de las celulas beta pancreaticas, deficiencia absoluta de insulina, tendencia a la cetoacidosis y necesidad de tratamiento con insulina para vivir (insulinodependientes).
EPIDEMIOLOGIAOMS y ADA: DM tipo 1 se desarrolla con mas frecuencia antes de los 10 anos, aunque puede producirse un proceso de destruccion autoinmunitaria de las celulas beta a cualquier edad. DIAGNOSTICOHistoria clinica y exploracion fisica: ?Valorar el estado nutricional, perdida progresiva de peso.
INSULINA- Tipos de insulina Actualmente se produce insulina humana biosintetica por tecnicas de DNA recombinante. LIBERACION DE INSULINALa primera fase o FASE TEMPRANA se inicia al primer minuto posterior a la estimulacion por glucosa, su pico maximo es entre 3 a 5 minutos, tiene una duracion maxima de 10 minutos y representa la insulina almacenada en los granulos de la celula beta.La segunda fase o FASE TARDIA inicia en forma lenta (a los 10 minutos), tiene una duracion de 4 horas (o mientras persista la hiperglucemia), tiene una produccion continua en forma de meseta con descenso lento y representa la insulina de nueva sintesis y produccion. VIA DE ADMINISTRACIONSubcutanea incluyendo su uso en bombas subcutaneas de infusion continua.
RECOMENDACIONES SOBRE ALMACENAMIENTOHUMALOG® se debe almacenar en el refrigerador entre 2 y 8°C. Insulin is a peptide hormone secreted by the pancreas in response to increases in blood sugar, usually following a meal. After a meal, the amount of insulin secreted into the blood increases as blood sugar rises. If these nutrients are shuttled primarily into muscle cells, then the muscles grow and body fat is managed. Without enough insulin, you lose all of the anabolic effects, since there is not enough insulin to transport or store energy or nutrients.
Continual elevation of insulin leads to large amounts of fat gain and risk for cardiovascular disease. Type 2 diabetes is characterized by obesity (particularly central deposition adiposity, or fat around the middle and deep in the abdominal cavity), cardiovascular disease, systemic inflammation, and the poor ability of muscles to store nutrients, which leads to muscle wasting and fat storage as well as nutrients circulating in the blood. Insulin resistance, and its associated metabolic syndrome, is a step along the road to type 2 diabetes. Due to the anabolic power of insulin, many over-fat individuals want to avoid insulin release.
You need insulin, but the trick is to learn how to balance the anabolic effects in muscle tissue against the fat storage effects. Aim for a moderate carbohydrate consumption (~40% of diet) with an emphasis on fibrous carbohydrates like vegetables, fruits, legumes, and whole grains. Investigate chromium and alpha lipoic acid, and make sure intake is adequate (but not excessive). While the glycemic and insulin indices of many foods are similar, some foods cause unexpected responses. The purpose of nutrient timing is to maximize insulin’s anabolic effects while minimizing its other problematic side effects.
Some epidemiologic studies have found that breast-feeding is associated with a reduced risk for developing insulin-dependent diabetes.
Supplementing infant diets with gluten-containing foods before 3 months of age may encourage pancreatic dysfunction.


Asian and African populations who are physically active and follow diets low in fat and high in fibrous carbohydrates have lower incidence of diabetes than those living the “Western” lifestyle.
The American Academy of Pediatrics stated that avoiding early exposure to cow’s milk may reduce the risk of developing antibodies to cow’s milk protein and type 1 diabetes. Alpha lipoic acid may increase glucose uptake in the cell by recruiting glucose transporters. Some people who are not obese by traditional measures are still at risk for insulin resistance anyway, particularly individuals with one or more close relatives who are diabetic, as well as many people of South Asian ethnic origin. Many bodybuilders have experimented with injecting insulin in an attempt to maximize insulin’s anabolic effects. To learn more about making important improvements to your nutrition and exercise program, check out the following 5-day video courses. They’re probably better than 90% of the seminars we’ve ever attended on the subjects of exercise and nutrition (and probably better than a few we’ve given ourselves, too).
Nota: Han transcurrido mas de 5 anos desde la publicacion de esta Guia de Practica Clinica y esta pendiente su actualizacion. El Centro de Tesis, Documentos, Publicaciones y Recursos Educativos más amplio de la Red.
Clasificacion Diabetes Mellitus Tipo 1 Tipo 2 Gestacional Otras Patologias Resistencia Pancreaticas, Autoinmune O deficiencia a Endocrinopatias La insulina Farmacos1997. Diabetes Mellitus tipo 1• Destruccion de celulas beta: deficiencia absoluta de insulina • Juvenil • Insulinodependientes • Anti-GAD45, anticelulas de islotes, antitirosina fosfatasa y antiinsulina • A. Tratamiento• Dieta• Ejercicio• Medicamentos • Insulina • Hipoglucemiantes: estimulan al pancreas• PREVENCION !!!
Prevencion• Mantener una nutricion adecuada evitando la ingesta exagerada de azucares y grasa.• Realizar ejercicios fisicos todos los dias, por el lapso de 30 minutos. Prevencion• Es decir que cambiando el estilo de vida y los habitos alimentarios, es la principal forma de prevenir la diabetes y sus complicaciones, logrando de esta manera mejorar la calidad de vida. If these nutrients are shuttled primarily into fat cells, then muscle mass is unchanged and body fat is increased. Since glucose is then poorly stored, people end up with both high circulating blood insulin and high circulating glucose. This can be done by increasing insulin sensitivity in the muscle while decreasing insulin sensitivity in the fat cells. In theory, it may help manage blood sugar, but trials using chromium have shown mixed results. Caffeinated coffee consumption impairs blood glucose homeostasis in response to high and low glycemic index meals in healthy men. Dynamic strength training improves insulin sensitivity without altering plasma levels and gene expression of adipokines in subcutaneous adipose tissue in obese men.
Association of insulin-dependent diabetes mellitus and celiac disease: a study based on serologic markers. Six months of gluten-free diet do not influence autoantibody titers, but improve insulin secretion in subjects at high risk for type 1 diabetes. Dietary intakes and plasma concentrations of carotenoids and tocopherols in relation to glucose metabolism in subjects at high risk of type 2 diabetes: the Botnia Dietary Study.


Dietary patterns, insulin sensitivity, and adiposity in the multi-ethnic Insulin Resistance Atherosclerosis Study population. Antioxidant effects of chromium supplementation with type 2 diabetes mellitus and euglycemic subjects. Chromium treatment has no effect in patients with poorly controlled, insulin-treated type 2 diabetes in an obese Western population: a randomized, double-blind, placebo-controlled trial. Exercise training and the antioxidant alpha-lipoic acid in the treatment of insulin resistance and type 2 diabetes.
No effect of a diet with a reduced glycaemic index on satiety, energy intake and body weight in overweight and obese women.
Dietary fats, fatty acids and insulin resistance: short review of a multifaceted connection.
A low-fat, vegan diet improves glycemic control and cardiovascular risk factors in a randomized clinical trial in individuals with type 2 diabetes. The effects of epigallocateghin-3-gallate on thermogenesis and fat oxidation in obese men: a pilot study. Effects of 3-week consumption of green tea extracts on whole-body metabolism during cycling exercise in endurance-trained men. Consulta nuestras Condiciones de uso y nuestra Politica de privacidad para mas informacion.
Consulta nuestra Politica de privacidad y nuestras Condiciones de uso para mas informacion. La administracion subcutanea de HUMALOG® debe realizarse en la parte superior de los brazos, muslos, gluteos o abdomen.Deben rotarse los sitios de inyeccion, de tal forma que el mismo sitio no se use mas de una vez al mes, aproximadamente.
No use HUMALOG® si esta turbio, espeso o con un color tenue, o si contiene particulas solidas visibles. Once insulin is in the blood, it shuttles glucose (carbohydrates), amino acids, and blood fats into the cells of the body.
Queda bajo la responsabilidad de cada lector el eventual uso que se le de a esta información. Diabetes idiopatica: Con igual comportamiento metabolico, pero sin asociacion con marcadores de autoinmunidad ni de HLA.
Se debe tener cuidado de no penetrar un vaso sanguineo cuando se inyecta la insulina lispro por via subcutanea. Keep in mind that a low glycemic diet can result in better fasted insulin and glucose, but results have been mixed. Los pacientes deben ser educados para utilizar las tecnicas de inyeccion apropiadas.Los requerimientos de insulina pueden estar reducidos en presencia de falla renal o hepatica. Una vez en uso puede almacenarse hasta por 28dias.PRESENTACIONESFrasco de 10 ml con 1,000 unidades. Sin embargo, el comienzo de accion mas rapido y la duracion de actividad mas corta de la insulina lispro en comparacion con la insulina regular, se mantiene en pacientes con falla renal o falla hepatica.



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